Sentences with phrase «cellular microenvironments»

For efficiently studying cell functions, it is essential to reconstruct cellular microenvironments by parallel manipulation of single cells.

To date, much of the research on irradiation's effects on the cellular microenvironment has dealt with samples that included cells, obfuscating the irradiation's effect on just the ECM rather than the cell's internal machinery.

«Laminins function as attractive chemical cues for haptotaxis of axonal growth cones,» explains NAIST Prof. Naoyuki Inagaki, whose lab studies how forces are generated in the cellular microenvironment to create directed axonal migration.

Instead, tumors should be considered complex tissues in which the cancer cells communicate with the surrounding cellular microenvironment and evolve traits that promote their own survival.

Instead, tumors should be considered as complex tissues in which the cancer cells communicate directly and indirectly with the surrounding cellular microenvironment and evolve traits that promote their own survival.

By blocking of an enzyme that affects the cellular microenvironment it is possible to stop brain tumour cells from growing.

The researchers found that loss of collagen VII not only affected the composition of the cellular microenvironment but also led to global changes in cell homeostasis on mRNA and on protein level.

Our research aims at identifying the principles of neuronal interactions with signals from the cellular microenvironment and uncovering disease - relevant targets that can be harnessed to drive drug discovery efforts in neurological and age - related neurodegenerative diseases.

Our microfluidic platform delivers precise control over the cellular microenvironment and beneficially through miniaturization, maximizes use of precious limited human cancer samples.

Not exact matches

The cell influences its microenvironment and, at the same time, the microenvironment influences cellular behavior — I am exploring this interrelationship.

Knowing how cells exert force and sense mechanical feedback in their microenvironment is crucial to understanding how they activate a wide range of cellular functions, such as cell reproduction, differentiation and adhesion — basic physiological processes that underlie embryo development, tumor metastasis, wound healing and many other aspects of human health and disease.

We are particularly interested in leverage our interdisciplinary expertise in polymer chemistry, nanomedicine, drug delivery and immunobiology to innovate new approaches to modulate the tumor microenvironment and enhance cellular immune responses to cancer vaccines.

For 2018, the CIMT program committee is preparing plenary sessions from pre-clinical research to clinical development on the topics of therapeutic vaccination, cellular therapy, improving immunity, tumor microenvironment, antibodies, regulatory research and immunoguiding.

The cellular composition of the tumour microenvironment affects how well a tumour can grow and the extent to which it responds to targeted and immune - modulatory therapy.

Our company focuses on the development of innovative immunotherapies for cancer based on genetically engineered lymphocytes and cellular components of the tumor microenvironment.

Finally, in collaboration with physicists from the Institute Curie, we are also investigating if, in addition to cellular and biochemical tumor microenvironment, mechanical pressure imposed by stroma can stimulate invasion of cancer cells.

Over the past few years, they have extended their research to understand how products of cellular necrosis and the innate immune responses they induce affect the tumor microenvironment, with a specific focus on ovarian cancer.

The Vaccine & Immunotherapy Center brings together many outstanding researchers within the Institute to focus on new immune based approaches to induce protective tumor immunity, to control the tumor microenvironment, and to use humoral and cellular immunity to control or eliminate cancer.

Dr. Jain's nominators note that, in sum, his work has provided ``... unprecedented molecular, cellular, anatomical and functional insights into the vascular pathophysiology of tumors, for proposing the seminal hypothesis that antiangiogenic therapy can «normalize» the aberrant vasculature and microenvironment of tumors and thereby improve both delivery and efficacy of treatment of solid tumors.»

Colonic insult impairs lymph flow, increases cellular content of the lymph, alters local lymphatic microenvironment, and leads to sustained inflammation in the rat ileum.

Keywords: Psychoneuroimmunology, mental strain and course of cancer, cellular immunity, neurohumoral interactions, microenvironment