Sentences with phrase «cellular model as»

Human Embryonic Stem (hES) cells derived from Preimplantation Genetic Diagnosed (PGD)- embryos offer a new alternative source of cellular model as they can be largely expanded, differentiated in several cell types and harbors «naturally» the causative mutation of the pathology.

Not exact matches

They then tested the contributions of samples from breast milk as well as individual molecules in both animal and cellular models of infection, measuring the length of time until resolution.

The report, which drew heavily on two Environmental Protection Agency (EPA) workshops held in 1995, also recommends more research on such topics as DNA biomarkers that can gauge an organism's exposure to endocrine disruptors; models for predicting how endocrine disruptors are metabolized; mechanisms of how endocrine disruptors act at a cellular level; and the effects of mixtures.

To find out why, computational biologists came up with a computer model to predict how microbial metabolism and cellular composition change as cell size varies, using details about how much space a bacterium needs for its components — DNA, proteins, and the molecular factories called ribosomes — to function.

Named after the IBM Blue Gene supercomputer it relies on, the Blue Brain Project has started modelling — in every detail — the cellular infrastructure and electrophysiological interactions within the cerebral neocortex, which represents about 80 % of the brain and is believed to house cognitive functions such as language and conscious thought.

Another experiment, one designed by students, will observe fruit flies as a research model for learning how diseases work at the cellular and molecular levels.

Dr. Marc Baum, the lead scientist at Oak Crest and co-author of the work, stated «this model is unique as it faithfully recreates the vaginal environment ex vivo, both in terms of the host cellular physiology and the associated complex vaginal microbiomes that could not previously be cultured.

Drosophila serves as a model organism that helps geneticists to decode the molecular fundamentals of cellular biology and unravel mechanisms that are conserved in human beings and other vertebrates.

Using the nascent skin of the developing chicken embryo as a model system, we find that morphological and molecular symmetries are simultaneously broken by an emergent process of cellular self - organization.

When this model was in its softest mode, normal (benign) mammary epithelial cells behaved normally within it, forming cellular structures referred to as acini that capture many key features of the normal in vivo mammary epithelium.

The research approach is called multi-scale modeling or MSM, to reflect the ability to study disease processes at the molecular, cellular, and tissue levels as well as interactions occurring between the levels.

«This camera has the potential to greatly enhance our understanding of very fast biological interactions and chemical processes that will allow us to build better models of complex, dynamical systems such as cellular respiration, or to help doctors better deliver and monitor light - based therapies,» says Richard Conroy, Ph.D., program director for Optical Imaging at NIBIB.

Scientists use it as a model organism for studying cellular signals, disease, and the movement of cells in response to a chemical stimulus (chemotaxis).

If the work proceeds as expected, «all interactions between genes, proteins, and small molecules will be revealed, and the whole cellular network will be reconstructed,» says Igor Goryanin, who heads cell modeling at GlaxoSmithKline in Stevenage, U.K.

«The development of this microfluidic lung model, as well as other organs - on - chip, holds the promise of improving the physiological relevance of cellular models for more accurate prediction of the effects of toxicants and drugs on humans, and for reducing the use of animals in medical and pharmaceutical research,» said Sonia Grego, Ph.D., research scientist at RTI and the project's principal investigator.

There, she has established the worm C. elegans as a novel model organism to examine the cellular transformations involved during a direct reprogramming event in vivo, as well as the genetic cascade involved.

We investigate cellular and molecular mechanisms of retinal degeneration and regeneration using rodents and human cells as model systems.

Amy Gladfelter's «Companions in Discovery» follows her lab's investigations into the physical properties of cellular proteins by using the fungus, Ashbya, as a lab model.

A second line of research is to use skeletal muscle formation in the chick embryo as a model to understand how cells within tissues display complex behaviours while being exposed to an ever - changing cellular environment.

as a model to understand molecular and cellular coding principles underlying olfactory behavior.

My lab at HPU studies membrane traffic during times of cellular stress using baker's yeast as a model system.

Chung and Khurana used the wealth of data from the yeast alpha - synuclein toxicity model to clue them in on key cellular processes that became perturbed as patient neurons aged in the dish.

«I highly respect Novocell technologies and am pleased to collaborate with Novocell and explore the potential of their hES cell to islet cell advances in combination with our iPS cells as a potential new sources for the generation of cellular models and therapies for diabetes,» said Dr. Yamanaka, Director of Center for iPS Research and Application at Kyoto University.

Ray uses Drosophila as a model to understand molecular and cellular coding principles underlying olfactory behavior.

She continued to develop these models and to investigate the molecular and cellular mechanisms underlying human tumor dormancy as an instructor in Folkman's lab and later as an Assistant Professor at the Center of Cancer Systems Biology at Tufts University School of Medicine, Boston.

The researchers focused on a well - known enzyme — called RNA polymerase II (RNAPII)-- and used the single - cellular yeast species S. cerevisiae as a model.

The Unit's scientific mission covers the design, synthesis, molecular modeling, as well as biophysical, biochemical and cellular studies of small - molecule probes and drug candidates targeting nucleic acids or proteins involved in cancer.

Using replicative senescence as a cellular model, we will dissect the functions of ATR and ATM in the process of aging and in premature aging diseases.

In 2010, we formally demonstrated ADE by developing a mouse mode of ADE - mediated disease, and we began to dissect the contribution of humoral vs. cellular immune components in dengue vaccine - mediated protection using model vaccine candidates as tools to probe the mechanisms by which the vaccine - induced immune responses in mice contribute to protection vs. ADE.

This models depicts the ES cell as a highly plastic but nevertheless discrete and stable cellular entity, one that in turn gives rise through a massive switch in gene expression to discrete progenitor populations with more limited developmental potential.

The Reactome Knowledgebase (https://reactome.org) provides molecular details of signal transduction, transport, DNA replication, metabolism, and other cellular processes as an ordered network of molecular transformations - an extended version of a classic metabolic map, in a single consistent data model.

Our group focuses on this question and uses the cnidarian Nematostella vectensis as a model organism to study how such morphological plasticity mechanisms are encoded at the molecular and cellular level.

London, UK About Blog BMC Neuroscience is an open access journal publishing original peer - reviewed research articles in all aspects of the nervous system, including molecular, cellular, developmental and animal model studies, as well as cognitive and behavioral research, computational modeling and systems neuroscience.

They will continue to inflate the price of such devices in the newer models as they do for the cellular telephones.

While the Note 8.0 doesn't offer as much SKUs as apple's offerings, it does feature a cellular model and uses a mSD card slot to expand available memory.

I also buy the wifi only model, as I don't need the cellular connectivity.

A Kindle model that can also get online using the cellular network, as earlier models do, costs $ 50 more.

Most devices offer Wi - Fi as the base level wireless connection — at a much lower cost — with 3G cellular data only available as part of a more - expensive model.

There's no camera, front or rear; the 8 GB of onboard storage is half the amount of the base - model iPad; the Fire has no cellular options, no built - in GPS, and no Bluetooth, as the iPad does.

When it comes to wireless connectivity, Samsung is expected to launch Wi - Fi - only as well as cellular SM - T800 models.

The GizmoTab's cellular connectivity is the major reason how it stands out from the rest of the child - friendly tablets, as all other models are Wi - Fi only.

Other tablets, such as the iPad 2 and several Galaxy Tab versions, however, connect to 3G / 4G cellular as well as Wi - Fi, but also have Wi - Fi - only models.

Our review model is the cellular version of the new iPad, which costs a little more, and there's a SIM card slot on the same edge as the volume buttons.

The 16 GB cellular model costs $ 460 - nearly as much as a Wi - Fi only full - sized iPad.

The cellular models in both devices support LTE, as long as your carrier provides it.

Both the 8 - inch version and the 9.7 - inch version will come as either a Wi - Fi only version or a Wi - Fi and cellular version, for a total of four Galaxy Tab S2 models.

The dot is limited to just the Series 3 model with cellular connectivity, as it's an indicator of the added connectivity.

Prior to the original model's release in 2013, smartphones that cost less than $ 400 were looked at as throw - ins when purchasing a cellular plan, but Motorola's refined looks and balanced performance have raised the bar in the budget segment.

As first reported today by MacRumors, and based on Apple's own page dedicated to availability for the cellular version of the Apple Watch 3, that model will be landing in Thailand on Thursday, April 5.

But those devices are slightly more affordable, and in Apple's case, you can snag a watch with cellular connectivity for the same price as the music - free model of the Forerunner 645.