Sentences with phrase «cellular model of»

One source told us that the company is working on a cellular model of its smartwatch, which hopefully will have a better fate than the LG Watch Urbane 2nd gen. LTE.

PUBG Mobile has already reached No. 1 on each Google Play and the App Store, dethroning the cellular model of Fortnite: Battle Royale, which was beforehand sitting at No. 1 on the latter's Free Apps chart.

Unlike the cellular model of Fortnite, PUBG Mobile is accessible to all gamers with an iOS or Android machine, which has undoubtedly performed a component in its fast ascent to the highest of the charts.

A small molecule activator of p300 / CBP histone acetyltransferase promotes survival and neurite growth in a cellular model of Parkinson's Disease

This study is the first to investigate the phenotypic effects of the HAT activator CTPB, and to demonstrate that p300 / CBP HAT activation has neurotrophic effects in a cellular model of PD.

Jingchun Chen (Nevada Institute of Personalized Medicine) received a UNLV IDeA Pilot Grant in the amount of $ 69,300 for her pilot study to develop a cellular model of microglia for schizophrenia research.

The cellular model of the airway mucosa could provide insight into biological and pathophysiological effects that conventional cell cultures or animal models do not capture, and help lead to the development of new therapeutics.

Salk scientists create new molecular scissors to correct protein imbalance in cellular model of dementia

While these studies were performed using a cellular model of hypertension, the implication of vitamin D3 on dysfunctional endothelium is much broader.

For instance, CiRA's Kohei Yamamizu recently reported developing a cellular model of the blood — brain barrier made entirely from human iPS cells.

To do this, they created a cellular model of Werner syndrome by using a cutting - edge gene - editing technology to delete WRN gene in human stem cells.

They then tested the contributions of samples from breast milk as well as individual molecules in both animal and cellular models of infection, measuring the length of time until resolution.

In recent years, Muotri and colleagues have created in vitro cellular models of autism using reprogrammed induced pluripotent stem cells (iPSC) derived from discarded baby teeth of children with autism, work dubbed the «tooth fairy project.»

This new bone cancer model does a better job than previously used mouse or cellular models of «recapitulating» the features of bone cancer cells driven by key genetic changes.

This flexibility gives us more versatility when creating cellular models of disease and development.»

Here, Anna presents how studies of neural stem cells and neurons derived from iPS cells of patients show faithful mimicking of known disease phenotypes in our cellular models of disease, like Alzheimer's disease, autism, and Down syndrome.

He has developed novel cellular models of neurological diseases (schizophrenia, MS, autism, Alzheimer's, Parkinson's) using human induced pluripotent stem cells (iPSCs) derived from donor patients and differentiated to specific neuronal cell types.

Other programs will use cellular models of heart disease created from stem cells to identify potential new drug targets.

The Cancer, Ageing and Somatic Mutation Programme seeks to provide leadership in data aggregation and informatics innovation, developing high - throughput cellular models of cancer for genome - wide functional screens and drug testing, and exploring basic scientific questions about the role somatic mutation plays in clonal evolution, ageing and development.

The advent of human - induced pluripotent stem cell (hiPSC) technology has provided a unique opportunity to establish cellular models of disease from individual patients, and to study the effects of the underlying genetic aberrations upon multiple different cell types, many of which would not normally be accessible.

The project will analyse the chemical changes that occur in Unkempt in human cellular models of TSC.

Technology utilizing human induced pluripotent stem cells (iPS cells) has enormous potential to provide improved cellular models of human disease.

Most recently, the update started rolling out to the Sprint Galaxy S5, that same device on Verizon, and Google's own cellular models of the Nexus 7.

Last month, we noted that the cellular models of Apple's latest tablets had received domestic network licenses, a required step before devices go on sale in China.

Not exact matches

The price of the new tablet starts at $ 399 for the 16 GB Wi - Fi model and goes up from there, peaking at $ 829 for the 128 GB model that can connect to the internet using cellular networks.

The model has allowed scientists to get a much closer look into the cellular interactions and biological behavior of M. genitalium, a very simple bacterium that is sexually transmitted between primates and can cause itching, burning or discharge.

We combine artificial intelligence with automation to conduct experimental biology at scale — testing thousands of compounds on hundreds of cellular disease models in parallel.

The disruption of prenatal cellular activity in zebra fish, which share 80 percent of their genes with humans and are considered a good model for studying human brain development, seemed to result in hyperactivity, according to the Canadian study, which was published Monday in the Proceedings of the National Academy of Sciences.

The researchers found that the immune cells in the skin of this animal model generated large amounts of the cytokine IL - 17 — a protein of the immune system that activates cellular inflammation in response to damage.

Using iPSCs, researchers developed a novel cellular disease model to probe the neurobiological causes of schizophrenia, which are not well understood (ChangHui Pak, abstract 032.29, see attached summary).

They used this novel simulation approach to build a model of a sperm cell that demonstrates cellular movement from individual dynein protein molecules in the tail all the way up to the whole cell, allowing them to observe how changes at the atomic level are reflected in larger - scale structures.

«The previous cellular models were great,» says John Hogenesch, Professor of Pharmacology at the University of Pennsylvania Perelman School of Medicine, «but they needed high end imaging equipment that is out of reach for most labs and early stage startups.»

In this new study published in Nature, Alexandra Van Keymeulen and colleagues used state of the art genetic mouse models to identify the cellular origin of PIK3CA and p53 induced breast tumors.

The scientists are testing the ability of drugs already on the market to reverse this cellular transformation in the pancreas in mice models of human pancreatic cancer.

Now, in this week's issue of the Proceedings of the National Academy of Sciences, Thomas Albright and Ricardo Gil - da - Costa of the Salk Institute for Biological Studies describe a model system that completes the bridge between cellular and human studies of schizophrenia, an advance that should help speed the development of therapeutics for schizophrenia and other neurological disorders.

«Transplanted hematopoietic stem cells reverse damage caused by neuro - muscular disorder: In mouse model of Friedreich's ataxia, a single infusion measurably restored normal cellular functions.»

While scientists could do cellular work in animal models on the role of dopamine versus glutamate, and they could do EEGs in human beings, a bridge between the two remained elusive.

Researchers at University of California San Diego School of Medicine report that a single infusion of wildtype hematopoietic stem and progenitor cells (HSPCs) into a mouse model of Friedreich's ataxia (FA) measurably halted cellular damage caused by the degenerative disease.

The report, which drew heavily on two Environmental Protection Agency (EPA) workshops held in 1995, also recommends more research on such topics as DNA biomarkers that can gauge an organism's exposure to endocrine disruptors; models for predicting how endocrine disruptors are metabolized; mechanisms of how endocrine disruptors act at a cellular level; and the effects of mixtures.

«Then we can do hypothesis - driven studies of this trait with animal or cellular models.»

Although the cause of the disease has remained unknown on a cellular level, there have been several different models established to explain its development.

The next step in this line of investigation, already in development, is to learn how cellular responses vary, on a molecular level, among roots of flooded plants when the hormone is not present, which would make it possible to create a response model where this signaling path would play a key role.

Using this approach, researchers can easily generate diseaserelevant isogenic models to determine the impact of correcting or introducing disease - relevant mutations on cellular phenotypes in a tissue - appropriate context.

Interestingly, when compared to human cellular models, mouse models of PD did not demonstrate the same toxic cascade, according to the study.

Named after the IBM Blue Gene supercomputer it relies on, the Blue Brain Project has started modelling — in every detail — the cellular infrastructure and electrophysiological interactions within the cerebral neocortex, which represents about 80 % of the brain and is believed to house cognitive functions such as language and conscious thought.

These models can be used to explore the cellular role of PCSK9 in vitro and to test the efficacy of cholesterol - lowering agents.

With CiPA, human iPSC - cardiomyocytes are employed to assess drug effects on the cardiac action potential to confirm the outcome of in silico modeling efforts, relying on hiPSC - cardiomyocytes to provide the integrated drug response from multiple native human currents in a human - derived cellular preparation.

«Within weeks he had the project running at full speed, so much so that we will complete the cellular - level model by the end of the year.»

Those tests don't give us the details we need to understand the nature of the pathology at the cellular level, so we modeled the disease to perform a systematic analysis of the optic nerve, from its origin in the eyes to termination in the brain.»

Dr. Marc Baum, the lead scientist at Oak Crest and co-author of the work, stated «this model is unique as it faithfully recreates the vaginal environment ex vivo, both in terms of the host cellular physiology and the associated complex vaginal microbiomes that could not previously be cultured.