Over the past few years, they have extended their research to understand how products of
cellular necrosis and the innate immune responses they induce affect the tumor microenvironment, with a specific focus on ovarian cancer.
The new findings show how death spreads through the organism via the process of
cellular necrosis.
A critical next step for this work is to understand how senescent changes in late life trigger such destructive waves of
cellular necrosis.
Not exact matches
Scoring - 0 - no definite pathology, 1 - mild peribronchiole and perivascular
cellular infiltration, 2 - moderate peribronchiole and perivascular
cellular infiltration, 3 - severe peribronchiolar and perivascular
cellular infiltration with thickening of alveolar walls, alveolar infiltration and bronchiole epithelial cell
necrosis and debris in the lumen.
Ionizing radiation is a potent DNA damaging agent that interacts with
cellular DNA and induces lesions in the irradiated cells and prevents cell proliferation and induces cell death by apoptosis or
necrosis depending on the radiation dose.
The higher scores (> 3) in some groups related primarily to the fact that virus infection had induced inflammatory infiltrates and epithelial cell
necrosis with desquamation of the epithelium and collection of
cellular debris in airways of these animals.
At the
cellular level, L - arginine administration resulted in acinar cell
necrosis in both WNIN / Gr - Ob and control rats.
In the vaccine comparison experiment, lung lesion scores for histopathology were graded for individual animals on a scale of 0 to 4 where 0 — 2 represented degree of
cellular infiltration and 3 — 4 represented the degree of bronchiolar epithelial cell
necrosis and airway
cellular debris (figure 2A).
Scoring 0 - no definite pathology, 1 - mild peribronchiole and perivascular
cellular infiltration, 2 - moderate peribronchiole and perivascular
cellular infiltration, 3 - severe peribronchiole and perivascular
cellular infiltration with thickening of alveolar walls, alveolar infiltration and bronchiole epithelial cell
necrosis and debris in the lumen.
Kontoyiannis D., Boulougouris G., Manoloukos M., Armaka M., Apostolaki M., Pizarro T., Kotlyarov A., Forster I., Flavell R., Gaestel M., Tsichlis P., Cominelli F., Kollias G., 2002, «Genetic dissection of the
cellular pathways and signaling mechanisms in modeled tumor
necrosis factor - induced Crohn's - like inflammatory bowel disease», JEM, 196, 1563 - 74.
Their antioxidant and anti-inflammatory activities are largely due to their abilities to scavenge the reactive oxygen species (ROS) and improvement of antioxidant status by attenuating the activity of NF - κB and suppressing the expression of several inflammatory cytokines and chemokines including monocyte chemotactic protein - 1 (MCP - 1), nitric oxide synthase, cyclooxygenases, lipoxygenases,
cellular adhesion molecules, tumor
necrosis factor and interleukins.