Sentences with phrase «cellular nucleus»

Most such research focuses on mutations in the DNA of chromosomes within the cellular nucleus.

Up until now, however, it has been unclear what comes first during cardiomyocyte differentiation: the reorganization of the DNA's folding in the cellular nucleus or the DNA's methylation — and whether these mechanisms are dependent on one another.

Systemic lupus erythematosus (SLE) is an immune reaction against material from the body's cellular nuclei leaking out of dying cells.

Not exact matches

A magnified transmission electron microscopy view of the rat nucleus accumbens neurons containing mitochondria in different cellular compartments.

Previous research conducted at Mount Sinai found that the trafficking of protein molecules between the nucleus (the cellular compartment containing the genetic information of the cell) and the cytoplasm is altered in neurodegenerative disease.

Proteins called kinesins, for example, are natural nanomotors that support cellular functions such as mitosis (the chromosomal process that creates two nuclei from one parent nucleus) and meiosis (when the number of chromosomes per cell is reduced by one half).

In response to cellular stress that can cause cancer, the team found that LC3, chromatin, and laminB1 migrate from the nucleus — via the nuclear blebs — into the cytoplasm and are eventually targeted for disposal.

Neurobiologists at Heidelberg University have identified calcium in the cell nucleus to be a cellular «switch» responsible for the formation of long - term memory.

But UL138, the viral protein, is actually located outside the nucleus, at a cellular component called the Golgi.

Our body's master clock — a collection of about 50,000 neurons in the brain's suprachiasmatic nucleus — responds to external cues, such as light, and coordinates the cellular clocks in our organs and muscles.

The cellular proteins are located in the nucleus of the cell, where the virus maintains its genetic material.

In the past decade, researchers have used mouse models to unravel how cellular changes in the nucleus accumbens (NAc), a brain structure involved in action selection associated with arousal and reward, may contribute to addiction - related behavior.

The viral protein outside the nucleus is somehow preventing the cellular proteins in the nucleus from accessing the viral genome, which is also in the nucleus.

Previous studies in the lab showed that once HCMV is inside the cell, it quickly becomes latent by entering the cell's nucleus and co-opting a cellular protein called Daxx — part of the intrinsic immune system — to shut down its own replication, the process of reproducing its genetic material to make more copies of itself.

The goal of the NIH program, as described on its website, is «to understand the principles behind the three - dimensional organization of the nucleus in space and time (the fourth dimension), the role nuclear organization plays in gene expression and cellular function, and how changes in the nuclear organization affect normal development as well as various diseases.»

Like jewels in a vault, our precious genetic material is stored in the nucleus of a cell — sequestered away from potentially damaging cellular components and toxins so that no harm can come to it.

Working with mouse, fly and human cells and tissue, Johns Hopkins researchers report new evidence that disruptions in the movement of cellular materials in and out of a cell's control center — the nucleus — appear to be a direct cause of brain cell death in Huntington's disease, an inherited adult neurodegenerative disorder.

Moreover, they suggest, laboratory experiments with drugs designed to clear up these cellular «traffic jams» restored normal transport in and out of the nucleus and saved the cells.

RNA was once thought to be a mere middleman, carrying genetic messages from the DNA in the nucleus out to cellular structures called ribosomes, where it directs the production of proteins.

The answer to this daunting biological riddle is central to understanding how the three - dimensional organization of DNA in the nucleus influences our biology, from how our genome orchestrates our cellular activity to how genes are passed from parents to children.

First, some microbes developed a nucleus using cellular membranes to contain their DNA («eukaryotes»), perhaps through endosymbiosis.

One view of the Phylogeny of Life on Earth (at the University of California at Berkeley's Museum of Paleontology) highlights the role of archeabacteria among prokaryotes — as a separate «Archaea domain» apart from Eubacteria — in the development of cellular life with nuclei (eukaryotes).

On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.

This landmark revelation was the first definition of an entire cellular signaling pathway from the cell surface to the nucleus, providing an important paradigm for understanding intracellular signaling.

Cells are the units of organic life and store in their nuclei what constitutes the instruction manual for proper cellular functioning, the DNA molecule.

Scientists at the Pacific Northwest National Laboratory have added to the understanding of ERK with proof that ERK oscillates within cells; that is, it cycles continuously in and out of a cell's nucleus in response to cellular growth cues.

The Sarma laboratory is interested in the mechanisms of epigenetic gene regulation, or how the dynamic modifications of the architecture of chromatin, the complex of DNA and proteins within the nucleus of our cells, impacts gene expression and cellular function.

Whether a protein is found in the nucleus, cell membrane, or mitochondria can provide clues to the protein's cellular role.

Which is roughly where things stood until last year when Princeton bioengineers Marina Feric and Cliff Brangwynne published a paper in Nature Cell Biology describing their probing of cellular inner space, the cell nucleus, and their discovery that gravity could limit cell size.

With Cell Painting, a technique developed at the Broad, researchers tag eight cellular components and organelles (actin, cytoplasmic RNA, endoplasmic reticulum, Golgi apparatus, mitochondria, nucleus, nucleolus, and the plasma membrane) with fluorescent dyes.

The mRNA is released from the nucleus and then enters another cellular body known as a ribosome.

It has unique properties (a nucleus, to be exact) that make it great for cellular repair and generation.