Sentences with phrase «cellular oxidative»

Natural agents that can lower dangerous levels of cellular oxidative stress are considered paramount to lowering blood pressure in susceptible individuals.

Curiously, the same people who are copper toxic often are deficient in the bio-available copper their bodies need for cellular oxidative metabolism and other critical functions.

Electrolytes (a fancy name for micronutrients) are depleted rapidly, while antioxidants (such as vitamins A, C, E, CoQ10 and alpha lipoic acid) are utilized more quickly, in order to reduce the cellular oxidative damage caused by exercise.

The BCAAem also induces mammalian target of rapamycin (mTOR) activity (another marker of increased cellular oxidative capacity and mitochondrial gene expression) in cultured cardiomyocytes.

In the absence of cellular oxidative stress, Nrf2 levels in the cytoplasm are maintained at low basal levels by binding to Keap1 and Cullin 3, which leads to the degradation of Nrf2 by ubiquitination [2], [5]--[9].

C - type lectin SIGNR1 enhances cellular oxidative burst response against C. albicans in cooperation with Dectin - 1.

However, excessive generation of ROS and / or a fall in antioxidant defences can lead to indiscriminate damage, resulting in cellular oxidative stress [27].

Her research team found that cellular oxidative stress (arising because of reactive oxygen species) increases in mice exposed to THS, damaging proteins, fats and DNA, and leading to hyperglycemia (excess glucose in the blood stream) and insulinemia (excess insulin in the blood)-- a condition also called insulin resistance.

Not exact matches

Regular consumption of healthy saturated fat such as organic virgin coconut oil, promotes cellular health by reducing oxidative damage from free radical exposure.

Now 24, he is a first - year graduate student in the department of cellular and structural biology at the University of Texas Health Science Center in San Antonio (UTHSCSA), where he is studying the role of oxidative damage — the wear and tear inflicted upon the cell by toxic molecules called free radicals — in the aging process.

It regulates a cellular defense response that helps protect cells from oxidative damage caused by environmental toxins or carcinogens.

The Zaher lab has found that that oxidative damage to a single base (bold X) on a messenger RNA (the jagged ribbon) can jam the cellular nanomachine (green) that translates the mRNA into protein (ribbon into beads).

This metabolic demand makes brain cells particularly vulnerable to damage from oxidative stress, in which reactive oxygen species (ROS), sometimes called free radicals, exert toxic effects on cellular components.

Somatic cells generate their energy in an oxygen - fueled process called oxidative phosphorylation, which takes place in the mitochondria, also known as cellular powerhouses.

These studies show that the DNA found inside mitochondria, the cellular structures whose job is to provide cells with energy, is particularly vulnerable, most probably because they handle oxidative chemical reactions.

Oxidative states are generally considered to be indicative of cellular stress; however, cells inherently release harmful reactive oxygen species during energy production, neutralized by intracellular antioxidative buffering systems.

Red tide disrupted the energy metabolism and cellular protection mechanisms, inhibited their ability to regulate fluids and increased oxidative stress.

Copper is an essential cofactor for enzymes involved in diverse cellular processes, including oxidative metabolism, neurotransmitter synthesis, free radical detoxification, and iron uptake.

This work aims to investigate, mechanistically, the molecular processes related to dysregulation of factors that normally protect the eye against oxidative stress, thus impairing RPE and photoreceptor cellular metabolism and their survival in AMD.

Molecular characterization, expression analysis, and role of ALDH3B1 in the cellular protection against oxidative stress.

Significantly, cellular pathologies including impaired cellular trafficking and an increase in oxidative stress, were reduced by treatment with the identified compound.

Despite the protection offered by the cellular environment, the integrity of DNA is continuously challenged by a variety of endogenous and exogenous agents (e.g. ultraviolet light, cigarette smoke, environmental pollution, oxidative damage, etc...) that cause DNA lesions, interfering with proper cellular functions, such as transcription, inducing premature cellular death and finally premature ageing and organs dysfunctions.

of aberrant amyloid and tau in the retina, quantification of any neuronal degeneration, delineation of cellular stress responses of neurons and particularly glial cells, and investigation of oxidative stress.

The Keap1 - Nrf2 system has evolved to respond to intracellular oxidative stress; in particular the generation of reactive electrophiles produced from oxidation of endogenous cellular constituents as well as xenobiotics [2]--[4].

Analytical endpoints included examination... of aberrant amyloid and tau in the retina, quantification of any neuronal degeneration, delineation of cellular stress responses of neurons and particularly glial cells, and investigation of oxidative stress.

«We demonstrate that CTRP9 stimulates stem cells to secrete a number of proteins and molecules that not only protect stem cells from toxic cellular death, but also shield the heart from oxidative damage after heart attack,» said Dr. Ma.

We present the literature on pathophysiological processes that may hasten aging and its relevance to addiction, including: oxidative stress and cellular aging, inflammation...

This DNA becomes damaged in the course of normal cellular processes, and certain forms of mitochondrial DNA damage - to the thirteen genes needed for oxidative phosphorylation - produce malfunctioning mitochondria that can overtake their cells, either by replicating more readily or being more resistant to quality control mechanisms.

Observed toxicity was strongly correlated with intracellular oxidative stress, measured as protein carbonylation, but not to cellular uptake.

Carbohydrate coating on silver nanoparticles modulates both oxidative stress and cellular uptake, but mainly the first has an impact on toxicity.

It was found that toxicity correlates with oxidative stress rather than with cellular uptake.

Toxicity correlated to oxidative stress but not to cellular uptake.

The publication suggests that insulin, under certain circumstances, might reduce the cellular defense against oxidative stress more than previously anticipated.

Enhanced amyloidogenic processing of APP by the ß - site APP cleaving enzyme (BACE) and the γ - secretase complex and reduced clearance lead to increased intracellular levels of soluble oligomeric Aß, resulting in cellular dysfunction comprising e.g., synaptic failure, mitochondrial dysfunction, enhanced oxidative stress, neurotransmitter and neurotrophin depletion, inflammation, and apoptosis which is reflected in patients as clinical symptoms such as cognitive deficits [2, 3].

Certain particle compounds may directly generate ROS in vivo because of their surface chemistry (eg, metals, organic compounds, and semiquinones) or after bioactivation by cytochrome P450 systems (eg, polycyclic aromatic hydrocarbon conversion to quinones).6, 290 a, 290 b A particle surface or anions present on otherwise more inert particles may disrupt iron homeostasis in the lung and thereby also generate ROS via Fenton reactions.291 Other PM constituents may do so indirectly by the upregulation of endogenous cellular sources (eg, nicotinamide adenine dinucleotide phosphate [NADPH]-RRB- oxidase) 292,293 or by perturbing organelle function (eg, mitochondria) by taken - up PM components.261 Particle stimulation of irritant and afferent ANS fibers may also play a role in local and systemic oxidative stress formation.294 Given the rich antioxidant defenses in the lung fluid, secondarily generated oxidization products of endogenous molecules (eg, oxidized phospholipids, proteins) or a reduction in endogenous antioxidants per se may be responsible at least in part for the state of oxidative stress in the lungs (along with instigating the subsequent cellular responses) rather than ROS derived directly from PM and its constituents.

HZE ions, for example, produce greater adverse effects on cellular physiology through increased genetic alterations and perturbations to redox metabolism, leading to persistent elevations in oxidative stress13, 14,15.

Taurine is highly effective in eliminating free radicals and keeping the cells healthy and proper taurine supplementation will significantly decrease oxidative stress and fatigue in muscle tissue, reducing the inflammation associated with cellular damage.

Moringa works like an antioxidant in the body fighting oxidative stress, cellular damage, and inflammation.

This increases mitochondria function and initiates many healing processes inside the cells, including increasing cellular energy (ATP) production, reducing oxidative stress, and reducing inflammation.

These two plant medicines have been shown to decrease oxidative cellular damage and increase cellular energy, paramount to overcoming brain fog.

The combination of these activities helps to minimize the cellular damage and resulting inflammation caused by the various oxidative processes.

Stress resistance has not been assessed however and so the biological relevance of this finding is currently unknown.32 Several IER trials (75 - 85 % ER on restricted days) in overweight / obese populations have reported reductions in various markers of oxidative stress 37, 41, which in one study was accompanied by a complementary increase in the anti-oxidant uric acid.37 In a direct comparison of IER (75 % ER for two days / week) and CER, both ER strategies displayed equal efficacy in reducing levels of fast - acting advanced oxidation protein products (AOPP) after six months, which displayed a tendency to occur earlier (i.e. at three months) in the IER group.41 Levels of slow - acting (i.e. long term) AOPP tended to decrease in the IER group and increase in the CER group which the authors proposed may have resulted from IER - induced activation of autophagy, a key homeostatic cellular process in which dysfunctional or unnecessary cellular proteins are degraded and recycled.41 On the other hand, a follow - up study using similar IER / CER protocols demonstrated comparable reductions in AOPP in both groups after three months.48 Summary and Future Research Directions

He Shou Wu stimulates the production of Superoxide Dismutase (SOD), the most powerful antioxidant in the human body, which works to protect to cellular DNA from oxidative damage, which is widely believed to be one of the primary causes of aging.

One reason might be the role of fat in inducing oxidative stress and creating free radicals, which are highly reactive atoms and molecules that damage DNA and cellular walls, ultimately killing heart muscle cells.

It is the most powerful antioxidant in the body and helps protect cells from free radical damage and oxidative stress, thereby improving cellular health and strengthening the immune system.

Also noted by IER studies are an increase in the expression levels of silent mating type information regulation 2 homolog 1 (SIRT1), an NAD + - dependent deacetylase.20 The expression of SIRT1, also increased by prolonged ER in rodents, is linked to the up - regulation of cellular stress resistance and improved outcomes in animal models of metabolic, neurodegenerative and inflammatory diseases.106, 107These findings have been suggestively accompanied by improvements in resilience to disease progression in rodent models of Type 1 diabetic nephropathy 20, survival following induced ischaemic injury 21 and a reduction in oxidative stress.105

Free radical damage caused by electron - seeking, highly reactive, oxidative molecules has been identified as the source of many maladies through mechanisms such as inhibition of telomerase, changes to cellular permeability and DNA damage.

Being in a ketogenic state has been shown to promote cellular responses that ultimately lower inflammation and oxidative stress and optimize energy metabolism.

Leukotriene B4 (LTB4) plays an important role in several cellular processes involved in inflammation, including oxidative metabolism, enzyme release and stimulation of neutrophil migration and aggregation.

Coenzyme Q10 or «CoQ10», also known as ubiquinone, is an anti-oxidant that is essential for mitochondrial energy production and may play a role in cellular defense against oxidative damage.