Using these orthogonal measures of
cellular pathway analysis, we confirmed that HPP - 4382, in contrast to bardoxolone, did not induce significant cellular stress at high doses as measured by HSPA6 expression and that the mechanism of HPP - 4382 activity does not appear dependent on NF - B as ICAM1 expression is not induced by HPP - 4382 (data not shown).
Not exact matches
A proteomics
analysis revealed expression changes of 56 proteins, and a further protein
pathway analysis suggested their association with the cell morphology, the organization, and the increased
cellular movement and the proliferation.