Sentences with phrase «cellular pathways»

The primary defects that cause muscle degenerative diseases are affecting distinct cellular pathways; accordingly, there is a large variability in clinical pathology and onset.
Scientists have discovered a new cellular pathway that can promote and support the growth of cancer cells.
In particular, he is interested in explaining how inflammation in the body alters cellular pathways, resulting in cancers and other diseases.
«The mineral zinc acts as a catalytic, structural and signaling factor in the regulation of a diverse array of cellular pathways involving hundreds of enzymes and proteins,» he said.
New research, from the Perelman School of Medicine at the University of Pennsylvania, has uncovered cellular pathways in skin pigment cells that are activated by estrogen and progesterone — two of the main female sex hormones — and also identified synthetic hormone derivatives that specifically influence the pigment producing pathway.
Designed assays to evaluate novel drugs, with an emphasis on cellular pathways involving the enzymes poly - ADP - ribose polymerase, poly - ADP ribose glycohydrolase, cyclophilins and sirtuins.
We are also interested in the evaluation of novel agents which inhibit cellular pathways known to be important in myeloma pathogenesis.
These therapies target mutated components of key cellular pathways on which tumours have become dependent on for survival, yielding drastic initial response rates without the major side effects of traditional chemotherapies.
However, in addition to survival, the Rockefeller scientists believe that molecular targets should be identified by determining which cellular pathways have a low probability for developing resistance.
However, more information is needed on cellular pathways and targets affected by these inhibitors before pharmacological optimizations can be pursued.
Moreover, the team also identified cellular pathways required by the tumour cell to maintain expression of the less immunogenic gene variants.
Cell lines are the workhorses of biology, routinely stocked and studied in every laboratory to understand cellular pathways, receptors, targets, hormones, and all aspects of normal and malignant physiology.
Glutamine is used in many cellular pathways, including for the making of nucleotides, the building blocks of DNA and RNA.
«Newly discovered cellular pathway may lead to cancer therapies.»
But the finding that all these genetic differences trigger the same cellular pathway provides hope for others.
The findings begin to answer a «long - standing mystery» about the specific cellular pathways disrupted by sleep deprivation, says David Dinges, a neuroscientist at the University of Pennsylvania who wasn't involved in the study.
The multitude of cellular pathways targeted by anthelminthics is difficult to explain.
Whitehead Institute scientists report that the gene mutated in the rare hereditary disorder known as Birt - Hogg - Dubé cancer syndrome prevents activation of mTORC1, a critical nutrient - sensing and growth - regulating cellular pathway.
March 13, 2017 Parallel cellular pathways activate the process that controls organ growth A new study from the University of Chicago suggests that while proteins that control organ growth accumulate around the edges of cells, they actually function at a different cellular site.
Milk synthesis and secretion by the mammary gland involve numerous cellular pathways and processes (summarized in the table below).
«With this study, we have validated both NOX1 and NOX4 as core mediators of liver fibrosis and laid out the step - by - step cellular pathways that lead to this disease.»
«And early developmental brain enlargement can be explained by underlying molecular and cellular pathway dysregulation, leading to altered neuronal cortical networks.»
The other study showed how using a combination of drugs at increased potency could prove an effective therapy against glioblastoma by inhibiting the PI3K and MAPK cellular pathways.
The results suggest the simultaneous activation of certain molecular pathways — actions among molecules in a cell that can lead to change — in particular the MAPK and PI3K cellular pathways, triggered tumor initiation and produced increasingly dense low - grade gliomas that quickly progressed to glioblastoma multiforme (GBM).
«The parasite achieves this by sending proteins into the host cell that manipulate the host's own cellular pathways, enabling it to grow and reproduce.»
Genome editing is used in many different cell types and organisms to specifically modify genes for the interrogation of fundamental cellular pathways.
This software calculated the enrichment or depletion of individual ontological categories with genes that had changed expression and identified cellular pathways potentially relevant to hypoxia.
In adrenocortical carcinoma, niclosamide has anticancer activity through its inhibition of multiple cellular pathways and impairment of the cellular metabolism [43].
The Cosford lab employs medicinal chemistry and chemical biology approaches to probe cellular pathways that regulate cell survival pathways in deadly tumors.
This is why recent work in the field of cancer research has focused on picking apart the complex cellular pathways involved in the development of different cancers and identifying the roles of key proteins involved, with the goal of being able to discriminately and effectively eliminate cancerous cells from the body.
Another innovative method used to track cellular pathways involves the rabies virus.
The production of ROS and reactive electrophiles is counterbalanced by a conserved, well - defined set of cellular pathways leading to increased expression of oxidative stress - responsive proteins that degrade ROS, clear reactive electrophiles and increase cellular glutathione.
To answer how a cell becomes resistant to chemotherapy, one must understand that cancer often begins with a clone - a single mutated cell that either can be destroyed by the immune system, or mutated further as subclones, genetic aberrations resulting in an ever - evolving cellular pathway to cancer.
Using these orthogonal measures of cellular pathway analysis, we confirmed that HPP - 4382, in contrast to bardoxolone, did not induce significant cellular stress at high doses as measured by HSPA6 expression and that the mechanism of HPP - 4382 activity does not appear dependent on NF - B as ICAM1 expression is not induced by HPP - 4382 (data not shown).
The model will describe cellular pathways that contribute to tumor formation and explain in detail how the genetic disposition of an individual can activate expression of genes that drive uncontrolled cell growth and lead to cancer.
Distinct cellular pathways select germline - encoded and somatically mutated antibodies into immunological memory.
Novel treatments for cancer depend on the ability to modulate aberrant cellular pathways and effectively deliver therapeutics to the tumor.
And the team plans to use the pigs to help identify metabolic and cellular pathways common to the variety of NF1 mutations, to help target and develop better drugs.
Howard Hughes Medical Institute researchers have pinpointed defects in a critical cellular pathway that can lead to the death of dopamine - producing nerve cells and ultimately symptoms of Parkinson's...
Now researchers at the Salk Institute for Biological Studies have identified an essential cellular pathway in zebrafish that paves the way for limb regeneration by unlocking gene expression patterns last seen during embryonic development.
Like NF - κB, several other cellular pathways are effected by terpene and plant chemicals.
Dietary fiber and bacterial SCFA enhance oral tolerance and protect against food allergy through diverse cellular pathways.
EDMONTON, ALBERTA — Researchers have identified a key cellular pathway by which the herbal medicine ginkgo biloba may protect brain cells.
Using DOS and small - molecule screening, Schreiber helped illuminate many cellular pathways, including the nutrient - response signaling network involving TOR proteins in yeast and mTOR in mammalian cells.
For several disorders known to arise from mutations in any one of a few distinct genes, the corresponding protein products have been shown to participate in the same cellular pathway, molecular complex, or functional module.
«We found that a specific cellular pathway, AMPK - PGC1a, likely plays a key role to reduce mitochondrial function and content, which means that new therapeutic approaches that restore and increase mitochondrial function and content could ameliorate or perhaps even arrest chronic kidney disease.»
A nanoparticle delivery system exploits biochemical and cellular pathways in tumor cells to deliver two different drugs to different locations in the cell.
a b c d e f g h i j k l m n o p q r s t u v w x y z