Sentences with phrase «cellular pathways known»

We are also interested in the evaluation of novel agents which inhibit cellular pathways known to be important in myeloma pathogenesis.

The growth of pNET malignant cells is closely tied to a cellular pathway known as mTOR (mammalian target of rapamycin).

Not exact matches

When mutated, BRAF, an enzyme that acts in a signaling cascade known as the MAPK / ERK pathway, becomes overactive and leads to increased cellular growth, a hallmark of cancer.

Rapamycin, which is an inhibitor of the mammalian target of rapamycin (mTOR) signaling pathway, has a variety of cellular functions and is known to possess both immunosuppressant and anti-tumor properties.

«The mechanism we demonstrated is the most sensitive cellular thermometer known to date, since the signaling pathways that trigger a heat shock or cold shock hardly react in this physiologically relevant temperature range,» explained Prof. Dr. Florian Heyd.

Not much is known about the genes and cellular pathways that trigger GNRH release.

«Almost nothing is known» about the molecular and cellular mechanism by which water is detected in the mouth and throat, and the neural pathway by which that signal is transmitted to the brain, says Zachary Knight, a neuroscientist at the University of California, San Francisco.

The PI3K / AKT pathway is a suspect, and its well - known links to cellular proliferation and survival may be connected to mediating the change at the cellular level.

Researchers also know that a cellular pathway called the Wnt signaling pathway induces hair growth.

Known as much for its complexity as its vital role in regulating cellular and organismal growth, the mechanistic target of rapamycin complex 1 (mTORC1) pathway has seemingly been acting in mysterious ways.

Whitehead Institute scientists report that the gene mutated in the rare hereditary disorder known as Birt - Hogg - Dubé cancer syndrome prevents activation of mTORC1, a critical nutrient - sensing and growth - regulating cellular pathway.

First, Nanog opened two key cellular pathways, known as Rho - associated protein kinase (ROCK) and Transforming growth factor beta (TGF - β).

Cathie (John Innes Centre and University of East Anglia, Norwich, UK) is well known for her earlier research on cellular specialization in plants and on the phenylpropanoid pathway.

We know that the lemony aura of limonene is more than just a scent, as it can be found in our blood after exposure.8 Furthermore, several anticancer cellular pathways appear to be affected by the terpene limonene, leading some to suggest it has anticancer, or chemopreventative, benefits.9 While feeding it to rats in studies has revealed some efficacy against breast tumors, 10 we have a ways to go before we can make such bold claims in humans.

It outlines a clear chain of cellular events, from the binding of DNA, through a specific signaling pathway, to the reduction of proteins known to trigger inflammation.»