Sentences with phrase «cellular protein degradation»

Certain types of misfolded proteins defy eradication by the cellular protein degradation machinery and accumulate with age, causing cellular toxicity.

Not exact matches

The researchers reported the natural inflammatory response when a foreign substance like a hydrogel is introduced into a system and draws cells that secrete proteins involved in cellular infiltration, scaffold degradation, vascularization and innervation.

«If we can find molecules that modulate membralin, or identify its role in the cellular protein disposal machinery known as the endoplasmic reticulum - associated degradation (ERAD) system, this may put the brakes on neurodegeneration.»

The work has led him to explore the role of protein phosphorylation in a diverse array of cellular functions, including transformation, cell communication, cell adhesion, cell - cycle regulation, the control of gene expression, and protein degradation.

The scope of the journal encompasses all of «traditional» molecular biology (including DNA replication, recombination and repair, gene expression, RNA processing, translation, and protein folding, modification, and degradation) as well as studies of the molecular interactions and mechanisms that underlie basic cellular processes.

His research interests include cellular lipid and protein degradation systems — and their malfunction — in relation to Parkinson's disease and other synucleinopathies.

There is also another mechanism by which cellular amino acid nutrition impacts on mTOR signalling; this involves the amino acids generated within the lysosomes by intracellular protein degradation and autophagosomal digestion [23,24].

The cytoplasm is the site of important cellular activities, including cell division, many metabolic processes and protein degradation.

Because the cellular fraction contained proteins destined for degradation in addition to enzymes required for the reaction, the team began to suspect that APF - 1 was linked to degradation targets rather than to the proteases that destroyed them.

Subsequently, he made other critical links between the ubiquitin protein degradation system and proteins known to play central roles in vital cellular processes.

Glycated proteins and cellular structures have altered function, increased vulnerability to oxidative damage, and reduced degradation and clearance.6 Slowing the entry of glucose into the brain would delay these processes and possibly give the body's defenses more time to dispose of the AGEs.

In fact, without leucine, the body can't correctly decipher cellular instructions that stimulate protein synthesis and prevent the degradation of muscle tissue at times of nutritional inadequacies and recovery.

1 Insulin is also very anti-catabolic and suppresses protein degradation and stimulates cellular hydration — causing water retention within the muscle cells that translates into greater protein synthesis.

Studies are clear that cellular hydration via a «pump» is an effective way to enhance protein synthesis and lower protein degradation.