Sentences with phrase «cellular protein synthesis»

«What we are saying is that even without new cellular protein synthesis, once a new connection is made, or a pre-existing connection is strengthened during encoding, that new pattern of connections is maintained,» Tonegawa says.

Allan Jacobson, Ph.D., of the University of Massachusetts Medical School and co-founder of PTC Therapeutics, the company that developed ataluren, and David Bedwell, Ph.D., professor of the UAB Department of Biochemistry and Molecular Genetics, have sought to understand precisely how ataluren allows the ribosome, the machinery of cellular protein synthesis, to skip over these inserted stop signs and produce proteins that have normal or near - normal function.

Not exact matches

Geneticists passed from the formal genetics of individuals to cytogenetics at the cellular level, to the biochemistry of DNA in duplication and in protein synthesis at the molecular level, back to physiological and developmental genetics again at the cellular level and back to the level of the individual in behavioral genetics and beyond the individual to population genetics and the theory of evolution.

Ribosomes, the cellular factories that manufacture proteins, contain both RNA and protein, but exactly how all of the different ribosomal components contribute to protein synthesis is still not clear.

In the second, they worked out the conditions required to allow their synthetic helix to be appended to natural proteins during synthesis by cellular ribosomes.

Dr Christos Gkogkas, a Chancellor's Fellow in the University of Edinburgh's Centre for Discovery Brain Sciences, said: «Our study reveals that altered protein synthesis through eIF4E is a key cellular process in the brain that can go awry in depression.

Small molecule drugs were used to inhibit the function of a cellular pathway associated with protein synthesis.

Based on previous work and their own results, Drummond and his colleagues speculate that a central purpose of protein aggregation during heat shock is to reshape the cellular factory, focusing protein synthesis on proteins needed during stress.

In order to reach maturation and be sent to the cellular «machine» that deals with protein synthesis, the non-coding fragments contained in the mRNA, the introns, need to be removed, whereas the coding sequences, the exons, have to be linked together.

«Since protein synthesis is one of the most prominent hallmarks of cellular life, it shows that these new viruses are more «cell - like» than any virus anyone has ever seen before.»

After reaching its destination, the gel melts into liquid, releasing the cellular components and allowing protein synthesis to occur.

Previous studies have found that if synthesis of certain cellular proteins is blocked in mice immediately after an event occurs, the mice will have no long - term memory of the event.

The researchers also inhibited the synthesis of cellular proteins immediately after the training occurred.

Other proteins involved in cellular transport and protein synthesis were also identified.

Research Focus: Dr. Signer is a stem cell biologist whose trailblazing work on protein synthesis in hematopoietic stem cells opened the door to unchartered areas of cellular investigation.

LOS1: LOS1 may be involved in a variety of fundamental cellular processes, ranging from protein synthesis to DNA repair.

Dengue virus nonstructural protein 3 redistributes fatty acid synthase to sites of viral replication and increases cellular fatty acid synthesis.

Cellular Studies (CEL): The study of animal cells involving the use of microscopy to study cell structure and studies investigating activity within cells such as enzyme pathways, cellular biochemistry, and synthesis pathways for DNA, RNA, and protein.

The Unit's scientific mission covers the design, synthesis, molecular modeling, as well as biophysical, biochemical and cellular studies of small - molecule probes and drug candidates targeting nucleic acids or proteins involved in cancer.

These changes are necessary for cancer cells to meet the combined biomass and energy demands for growth and are only satisfied by increased capture and synthesis of cellular building blocks such as sugars, fats, and proteins.

Glutamine is an amino acid that plays a vital role in maintaining the muscle mass and enabling the synthesis of muscle protein on a cellular level.

This feeding cycle stimulates the production of cellular factors such as Cyclic AMP or GMP, which stimulate hormone synthesis and fat burning during the day, as well as protein synthesis and growth during the night, respectively.

• Increased lactate threshold leads to increased cellular swelling and increased anabolic hormone levels, which leads to increased protein synthesis.

is important or protein synthesis, cellular repair and bone health — so healthy individuals must get their full daily value.

Rats fed protein - deficient diets have decreased DBP concentrations and a decreased ability to regulate calcium metabolism.38 Humans with acute liver failure also have depressed levels of DBP.39 This may be because the synthesis of DBP in the liver declines during such a condition, but DBP also plays a secondary role in scavenging harmful cellular debris from the blood; therefore, any kind of acute tissue damage can overwhelm our supply of DBP.

Testosterone stimulates cellular amino acid uptake and protein synthesis in muscles by interacting with the DNA, as well as increasing muscle fiber site neurotransmitters.

As an adult, it does lots of other things, including increased bone mineralization and muscle mass, protein synthesis, cellular growth, and fat breakdown.

Muscle growth — HGH stimulates insulin growth factor 1 production that increases protein synthesis in the muscles through cellular division.

In fact, without leucine, the body can't correctly decipher cellular instructions that stimulate protein synthesis and prevent the degradation of muscle tissue at times of nutritional inadequacies and recovery.

[79] Acquired susceptibility, for example, impaired glutathione synthetase activity due to a RNA transcriptional error from haptenic binding and distortion of the mRNA complex or due to impaired and disordered protein synthesis due to low ATP production in the cellular mitochondria would have similar adverse effects [80].

Insulin is not needed for protein synthesis or to activate the mTOR pathway, that causes cellular growth.

1 Insulin is also very anti-catabolic and suppresses protein degradation and stimulates cellular hydration — causing water retention within the muscle cells that translates into greater protein synthesis.

Biotin serves as an essential coenzyme for five biotin - dependent carboxylase reactions that participate in numerous cellular processes and metabolic activities, notably fatty acid synthesis, amino acid catabolism and gluconeogenesis (making glucose from protein).

Studies are clear that cellular hydration via a «pump» is an effective way to enhance protein synthesis and lower protein degradation.

When elevated, HSPs aid in muscle protein synthesis — they speed up the muscle repair process by encouraging cellular repair.

Studies show that cellular swelling causes both an increase in protein synthesis and a decrease in protein breakdown (Grant et al., 2000; Stoll et al., 1992; Millar et al., 1997).

Increased cellular hydration is thought to reduce protein catabolism and increase the synthesis of DNA (8).

Of particular importance is the BCAA leucine, a potent independent stimulator of muscle protein synthesis in cell culture and animal models through enhanced cellular regulation of mRNA translation (29).

Tags for this Online Resume: clinical research scientist, protein synthesis and purification, IVF, cellular biology, molecular biology, infection and immunology