Sentences with phrase «cellular proteins»

As the primary site of cellular protein folding, the ER plays a critical role in maintaining cellular function.

The disruption of the microbiome reduced production of a key cellular protein vital to the barrier's effectiveness.

Previous studies have found that if synthesis of certain cellular proteins is blocked in mice immediately after an event occurs, the mice will have no long - term memory of the event.

This technology is based on observing drug induced changes in the thermal stability of cellular proteins.

In the new study, expanding upon what scientists previously understood about intrinsic immunity, the researchers found that cells can subsequently respond to latent HCMV by employing other cellular proteins called lysine demethylases to reactivate the virus.

Degenerative brain diseases like mad cow disease (officially known as bovine spongiform encephalopathy, or BSE), scrapie in sheep, and vCJD in humans are thought to be caused by prions, misfolded versions of a normal cellular protein called PrPC.

Once inside cells, they are taken up by cellular protein - making machinery and induce the production, over weeks, of the viral proteins they encode.

Allan Jacobson, Ph.D., of the University of Massachusetts Medical School and co-founder of PTC Therapeutics, the company that developed ataluren, and David Bedwell, Ph.D., professor of the UAB Department of Biochemistry and Molecular Genetics, have sought to understand precisely how ataluren allows the ribosome, the machinery of cellular protein synthesis, to skip over these inserted stop signs and produce proteins that have normal or near - normal function.

As a basic researcher, he has been most interested in looking for ideas that point toward new directions in the field: a new role for a protein or a new understanding of how cellular proteins drive the immune response.

These findings provide important novel insights into the mechanisms of cellular protein quality control as well as disease progression» Hartl concludes.

Ubiquitination was crucial to cellular protein degradation, and it had something to do with cell division.

As they report Sept. 28 in Nature Biotechnology, this tool should provide fast and reliable characterization of the different mechanisms cellular proteins use to bind to DNA strands — information that could shed new light on the atomic - scale interactions within our cells and help design new drug therapies against pathogens by targeting enzymes that interact with DNA.

These diseases are thought to be caused by prions (pronounced pree - ons), infectious protein particles — normal cellular proteins that supposedly change their shape and then mold other protein molecules into the same sickly altered form.

In contrast, measles requires binding to specific cellular protein receptors as its doorway.

We have now shown for the first time that it is the transcriptional suppression of genes that are important for cellular protein synthesis by Gcn4 that seems to account for its lifespan extension effect.

Some of Gierasch's more recent work has been focused on developing and testing experimentally a computational model of cellular protein homeostasis in E. coli in collaboration with Evan Powers of The Scripps Institute.

Finally, total radioactivity and total cellular protein of the lysate were determined.

Autophagy is a catabolic degradation process in which cellular proteins and organelles are engulfed by double - membrane autophagosomes and degraded in lysosomes.

This study reveals how lipids control SH2 domain - mediated cellular protein interaction networks and suggests a new strategy for the therapeutic modulation of pY - signaling pathways.

In humans and most other eukaryotes, the RNAi pathway can reduce cellular protein production by reducing the proteins» RNA templates.

The new study illuminated the way in which SAMHD1 interacts with several cellular proteins that play a critical role in regulating innate immune responses.

Stewart says his team's initial work has not only identified fibrillarin as essential for viable paramyxovirus replication — it also has shown that one can «deplete fibrillarin from cells or block its catalytic activity and the vast majority of cellular proteins still get made within the cell,» which suggests it is a safe target for intervention.

Gundlach believes this tool may open a new window for understanding how cellular proteins process DNA, which could help genetically engineer proteins to perform novel jobs.

«Our most important finding is that disease - promoting inflammatory cells in the mouse intestine can be targeted by oral formulations of purified cellular proteins, rendering the inflammatory cells less able to cause disease,» says first author Allen Chung, an MD / PhD student in the UB medical school's Medical Scientist Training Program.

EDD1 is an E3 ubiquitin ligase involved in degrading cellular proteins, while TIP60 act as a tumor suppressor protein, and can both be found in the human body.

With as many as a thousand tubes fitting into each cell, the tubular scaffold can be used to increase the bacteria's efficiency to make commodities and provide the foundation for a new era of cellular protein engineering.

The research team has been using NMR — a technique related to the one used in MRI body scanners and capable of visualising molecules at the smallest scales — to examine how small components of herpes virus help it to multiply by binding themselves with other large molecules; this produced images of a monkey herpes virus protein interacting with mouse cellular protein and viral RNA.

His research focus is on the mechanisms by which endogenous cellular proteins impact retroviral replication, in particular the interaction of cellular TRIM5α with retroviruses such as HIV - 1.

Scientists at the Stowers Institute for Medical Research have made a surprising finding about the aggregates of misfolded cellular proteins that have been linked to aging - related disorders such as Parkinson's disease.

Now, the team investigated how Dengue virus might affect protein translation and found that the global cellular protein translation is significantly suppressed, while translation of the Dengue viral proteins proceeds.

When cellular proteins fold improperly and clump together, they accumulate and form the plaque that is involved in the pathogenesis of Alzheimer's and other brain diseases.

The sugars contain many polar chemical groups, which take the place of water and stabilize cellular proteins and membranes until the parched period is over.

Scientists at the Max Planck Institute of Biochemistry in Martinsried, Germany, now discovered a new family of helper proteins that recognize labeled cellular protein waste and guide them efficiently to the lysosome for destruction and subsequent recycling into their reusable compounds.

That DNA is packaged up by winding around histones (middle), and small molecules called polyamides are able to bind to that DNA, unlike most natural cellular proteins.

«What we are saying is that even without new cellular protein synthesis, once a new connection is made, or a pre-existing connection is strengthened during encoding, that new pattern of connections is maintained,» Tonegawa says.

The researchers also inhibited the synthesis of cellular proteins immediately after the training occurred.

Hartl, a biochemist, and Horwich, a geneticist, are pioneers in the realm of cellular protein chemistry whose collaborations helped unravel the molecular machinery that assists with protein folding.

Fluorescent proteins (FPs) offer scientists a simple yet powerful way to tag cellular proteins and investigate protein localization, interaction, and expression.

For example, inflammation in brain tissue caused by either genetic susceptibility or triggered by accumulating cellular proteins and external events, such as severe concussions, will leave the brain more open to injury.

The tail ends of cellular protein templates, regions often thought relatively inconsequential, may actually play a role in preventing normal cells from becoming cancerous.

TDP - 43 levels were shown to be regulated by a third cellular protein called Ran.

Free radicals are dangerous to cell membranes, DNA, RNA, and cellular proteins because they bombard these cellular structures in search of electron stability.

In unfit but otherwise healthy middle - aged adults, two weeks of modified HIIT training prompted the creation of far more cellular proteins involved in energy production and oxygen.

These are circulated to the liver, where they are used to repairing and rebuilding cellular proteins.

At any given time, the liver is releasing a constant supply of amino acids to skeletal muscle for maintaining blood sugar levels and supporting cellular protein homeostasis.

It accumulates within the cells, and reacts with cellular proteins such as enzymes and DNA.