Sentences with phrase «cellular proteins fold»

When cellular proteins fold improperly and clump together, they accumulate and form the plaque that is involved in the pathogenesis of Alzheimer's and other brain diseases.

As the primary site of cellular protein folding, the ER plays a critical role in maintaining cellular function.

Not exact matches

Calcium, however, puts a strain on cells — it is known to hinder protein - folding and metabolism when it accumulates — disrupting normal cellular function.

Stella M. Hurtley Senior Editor Education: B.A., University of Cambridge; Ph.D., European Molecular Biology Laboratory, Heidelberg Areas of responsibility: Cell biology, cellular microbiology, membrane traffic, protein targeting, protein folding, organelle biogenesis, cytoskeleton, cell polarity, prion biology E-Mail: [email protected]

According to a groundbreaking study published in this week's online edition of the Proceedings of the National Academy of Sciences, they have chemically synthesized a record - length mirror - image protein and used this protein to demonstrate that a cellular chaperone, which helps «fold» large or complex proteins into their functional state, has a previously unappreciated talent — the ability to fold mirror - image proteins.

An additional challenge is that large proteins often require the assistance of cellular «chaperones» to fold into their functional state, and D - chaperones are not available.

Once constructed, those amino acid strings spontaneously fold up into proteins, each with a specific 3D shape that governs its cellular function.

During the early years of my PhD studies, I was very fascinated by the exciting discoveries in the field of signal transduction, in particular how receptor tyrosine kinases are activated to transmit their signals and how protein complexes are formed through defined protein folds (domains) interacting with specific cellular targets.

However, since folding and maintaining of such structures is highly sensitive to cellular or environmental stress, proteins can potentially misfold or form clumps (aggregates).

«Much work still lies ahead, but we are optimistic that the basic research toward understanding the cellular machinery of protein folding and quality control will eventually contribute to solving some of the most pressing medical problems of our aging population,» Hartl said.

Hartl, a biochemist, and Horwich, a geneticist, are pioneers in the realm of cellular protein chemistry whose collaborations helped unravel the molecular machinery that assists with protein folding.

The Kaufman lab is focused on understanding the fundamental mechanisms that regulate protein folding and the cellular responses to the accumulation of unfolded proteins within the Endoplasmic Reticulum (ER).

The ER is a cellular structure where protein production, folding and assembly occur.

The major portion of our research is aimed at elucidating fundamental mechanisms that regulate protein folding and the cellular responses to the accumulation of unfolded protein within the (ER).

The scope of the journal encompasses all of «traditional» molecular biology (including DNA replication, recombination and repair, gene expression, RNA processing, translation, and protein folding, modification, and degradation) as well as studies of the molecular interactions and mechanisms that underlie basic cellular processes.

Influenza viruses can hijack host cellular machinery to help mutated viral proteins fold and function.

«Correct protein folding is critically important, which is why we are focusing on the diverse set of complex cellular mechanisms, including molecular chaperones, that promote efficient folding and prevent toxicity,» says Dr. Adrian Israelson, who heads the Cellular and Molecular Neurodegeneration Lab in the BGU Department of Physiology and Cell Biology.