Sentences with phrase «cellular proteins use»

Gundlach and his team show that SPRNT is sensitive enough to differentiate between the mechanisms that two cellular proteins use to pass DNA through the nanopore opening.

Not exact matches

For example, Finless Foods uses cellular agriculture to develop faux fish meat, while New Wave Foods produces pea protein and algae - based imitation shrimp.

Like fellow Bay area start - up Geltor, Perfect Day is one of a new breed of companies in the «cellular agriculture» business — using genetically engineered yeasts that have been «programmed» to produce proteins or other ingredients found in plants or animals - on an industrial scale, without raising animals, and with less impact on the environment.

«Eventually you have to replace those genes with small molecules, with proteins, with whatever,» says Ding, who is working on cellular reprogramming methods that use small molecules, rather than viruses.

They all use RNA molecules as messengers to transfer the information from DNA to cellular factories called ribosomes, which then build proteins, which in turn drive our metabolisms and form the structures of our cells.

They used this novel simulation approach to build a model of a sperm cell that demonstrates cellular movement from individual dynein protein molecules in the tail all the way up to the whole cell, allowing them to observe how changes at the atomic level are reflected in larger - scale structures.

Purdue University physicists are part of an international group using spinach to study the proteins involved in photosynthesis, the process by which plants convert the sun's energy into carbohydrates used to power cellular processes.

The pilot project tested a dozen or so of the most commonly used gene promoters (regions of DNA that facilitate gene transcription) and segments of DNA that encode ribosome - binding sites (sequences of messenger RNA that control protein translation) to determine whether they behave consistently in different cellular contexts.

Using the same computer - based approach, the team has now been able to target the c - FLIP (cellular FLICE [FADD - like IL - 1β - converting enzyme]- inhibitory) protein, known to play a key role in cancer stem cell maintenance and survival, described in previously published work by the Institute.

Now, scientists at Princeton have used «designer chromatin'templates — highly customized replicas of cellular DNA and histone proteins, the scaffolding proteins around which DNA is wrapped — to reveal new details about Suv39h1's mechanism.

The following year, Frank prepared ribosomes, cellular structures that help make proteins, using the cryo - EM method.

Protein chemist Michael Way, cell biologist Sally Cudmore, and their colleagues at the European Molecular Biology Laboratory in Heidelberg and at the Pasteur Institute in Paris have found that vaccinia — a virus used in smallpox vaccines — surfs through cells on piles of actin, one of the basic structural proteins in the cellular skeleton.

After more than six years of research, the research team led by María Soengas, head of CNIO's Melanoma Group, showed that RAB7 acts as an orchestra director, determining the fate of melanoma cells: at high concentrations of RAB7, cellular autodigestion is very active, and this allows tumor cells to obtain energy, prevent the accumulation of toxic components and thus divide and proliferate; when RAB7 is reduced, cells use endosomes to recycle metastatic proteins, favouring their dispersal throughout the body.

Autophagy is also used for self - cleaning to eliminate other proteins as well as damaged or unneeded cellular components.

Called 6 diazo -5-oxo L norleucine, or DON, the drug blocks the cellular use of the protein building block glutamine.

To find out why, computational biologists came up with a computer model to predict how microbial metabolism and cellular composition change as cell size varies, using details about how much space a bacterium needs for its components — DNA, proteins, and the molecular factories called ribosomes — to function.

These cancers remodel proteins using the cellular self - cannibalization process known as autophagy to capture and degrade intracellular proteins and protein - containing organelles.

These proteins can not themselves be used to prevent bleeding episodes, because the cellular machinery found in plants can not package the human clotting factors into the biologically active form.

Modern cells use RNA to make proteins, the workhorses of cellular function, but RNA likely preceded both proteins and DNA.

With as many as a thousand tubes fitting into each cell, the tubular scaffold can be used to increase the bacteria's efficiency to make commodities and provide the foundation for a new era of cellular protein engineering.

According to a groundbreaking study published in this week's online edition of the Proceedings of the National Academy of Sciences, they have chemically synthesized a record - length mirror - image protein and used this protein to demonstrate that a cellular chaperone, which helps «fold» large or complex proteins into their functional state, has a previously unappreciated talent — the ability to fold mirror - image proteins.

Small molecule drugs were used to inhibit the function of a cellular pathway associated with protein synthesis.

The research team has been using NMR — a technique related to the one used in MRI body scanners and capable of visualising molecules at the smallest scales — to examine how small components of herpes virus help it to multiply by binding themselves with other large molecules; this produced images of a monkey herpes virus protein interacting with mouse cellular protein and viral RNA.

Using this system, Spence and Chandran showed that a specific cellular protein, called NPC1, must interact directly with the Ebola glycoprotein for fusion to occur.

The researchers discovered that from one stage to another, Capsaspora's suite of proteins undergoes extensive changes, and the organism uses many of the same tools as multicellular animals to regulate these cellular processes.

AMPK, or AMP - activated protein kinase, coordinates cellular energy use.

Using a multi-disciplinary approach involving electrophysiological, cellular and biophysical techniques, the researchers found that parts of the prion protein lacking the «brake» region produced abnormal electrical currents in cells.

That year's chemistry prize recognized three researchers for green fluorescent protein (GFP), now widely used as a cellular tagging tool.

Scientists have pioneered the use of a high - powered imaging technique to picture in exquisite detail one of the central proteins of life — a cellular recycling unit with a role in many diseases.

(Many viral pathogens are known to use cap - independent translation to hijack and redirect cellular mechanisms to translate viral proteins.)

The bug manufactures an amino acid not made by any other living thing and uses it to construct its proteins, the molecules that carry out the lion's share of cellular chemistry.

Biologists, biochemists and geneticists who need to visualize the anatomical location of cellular structure, proteins / enzymes, mRNA, and reporter genes within whole tissue are among those who can benefit from this innovative product, which can be used with light microscopy, fluorescence microscopy, confocal microscopy and single / multiphoton microscopy.

Our current research focuses on identifying the molecular and cellular interface that blood proteins use to interact with and change the functions of cells in the nervous system.

Cas9 uses short RNA molecules, known as guide RNAs, to target the protein to a specific sequence within cellular DNA.

«We are trying to build a novel technology that enables us to control a selected protein simply using light, moving the resolution of optogenetics from the cellular level to the molecular level,» said Wang, associate professor of Pharmaceutical Chemistry.

Amy Gladfelter's «Companions in Discovery» follows her lab's investigations into the physical properties of cellular proteins by using the fungus, Ashbya, as a lab model.

Cellular Studies (CEL): The study of animal cells involving the use of microscopy to study cell structure and studies investigating activity within cells such as enzyme pathways, cellular biochemistry, and synthesis pathways for DNA, RNA, and protein.

Finally, in a collaboration with Frank Jülicher's group at the Max Planck Institute for the Physics of Complex Systems, we are using these data to develop physical models that will help us understand how local cellular adhesive, elastic and contractile properties are influenced by PCP proteins and other molecules, and how they combine to produce specific packing geometries at a global level.

We work across disciplines and use a variety of techniques including microfluidics, standard microscopies (electron, optical, fluorescence, confocal), spectroscopies (fluorescence, UV, CD), scattering techniques (X-ray, light), protein expression and characterization and cell - free gene expression to investigate the utility of coacervate microdroplets as robust reaction compartments and cellular mimics.

It is produced by photophosphorylation and cellular respiration and used by enzymes and structural proteins in many cellular processes.

Using DOS and small - molecule screening, Schreiber helped illuminate many cellular pathways, including the nutrient - response signaling network involving TOR proteins in yeast and mTOR in mammalian cells.

Using tiny, alpaca - derived, single - domain antibody fragments, Whitehead Institute scientists have developed a method to perturb cellular processes in mammalian cells, allowing them to tease apart the roles that individual proteins play in these pathways.

The SMDC has allowed Gladstone scientists to design molecules to modulate the functions of proteins or specific cellular phenotypes and, most significantly, screen for drugs that could be used as therapies for disease.

Beyond the internal interactions of the protein itself, these designed oligomers can be used to explore basic questions about how the structure of signaling molecules affects the behavior of receptors and cellular response.

In a general sense, FP timers can be used in any situation where one wants to understand the relationship between the age of a cell, protein, or cellular structure and a particular biological event (trafficking to a subcellular location, start of gene expression, development of a cell structure, etc).

Comparing leaf development and cellular differentiation in the C3 species rice to that in the C4 species maize mainly using large scale comparative protein (proteome) analysis.

Our new study uses transcriptomics of cell fragments of the ciliate Stentor to reveal the importance of protein phosphorylation, microtubule - based processes and genes involved in the cell cycle for cellular regeneration.

To overcome this challenge, the students altered a sub-unit of curli DNA, called ribosome binding sites (RBS), and then used these modified RBS to specifically tune protein production, explained Erin Kim, A.B.» 19, a molecular and cellular biology concentrator.

The researchers are currently using the 4D microscope to image the components of cells, such as proteins and ribosomes, the cellular machinery that makes proteins.

We combine biochemical, structural, cellular and functional information using purified proteins, mutant and transgenic plants, yeast and chemical genomic screening systems, transient gene expression assays, confocal microscopy and in silico data analysis to compare ROP - centered kinase signaling during cell polarity (in vitro pollen tubes), morphogenesis (whole plant) and pathogenesis (fungi - infected cells).