Sentences with phrase «cellular receptors in»

Many of those efforts have focused on drugs that target cellular receptors in the brain called NMDA receptors.

Not exact matches

Clinically important findings suggest that targeting the epidermal growth factor receptor (EGFR) and the fibroblast growth factor receptor (FGFR) cellular pathways may benefit thousands of patients with this disease, according to the study published today in the journal PLOS Genetics.

If one component was missing in this triplet consisting of auxin transporter, receptor or calcium channel, there was no cellular response.

Cell lines are the workhorses of biology, routinely stocked and studied in every laboratory to understand cellular pathways, receptors, targets, hormones, and all aspects of normal and malignant physiology.

In their study, the Geneva researchers were also able to dissect the fine cellular mechanisms involved: Of the three estrogens receptors, only one is mainly involved in this protective effecIn their study, the Geneva researchers were also able to dissect the fine cellular mechanisms involved: Of the three estrogens receptors, only one is mainly involved in this protective effecin this protective effect.

Some researchers speculate that fatty acids help maintain fluidity in the cellular membranes, allowing neural receptors to better detect incoming signals.

To be viable, a hybrid's cellular machinery, for example, a protein and its receptor, must fit smoothly, as a peg in a hole.

NMDA receptors are key players in plasticity, the cellular process of learning and memory.

To create a more realistic mouse model of low MD activity, the team devised a new method that uses a virus to embed into the surface of MD neurons receptors that block cellular activity in the presence of a compound called clozapine - N - oxide.

What makes this technique novel is the accompaniment of an imaging agent known as Ga - 68 DOTATOC, which binds to somatostatin receptors in neuroendocrine cells that use the hormone somatostatin to mediate endocrine function, the release of neurotransmitters and cellular proliferation.

During the early years of my PhD studies, I was very fascinated by the exciting discoveries in the field of signal transduction, in particular how receptor tyrosine kinases are activated to transmit their signals and how protein complexes are formed through defined protein folds (domains) interacting with specific cellular targets.

«Our experiments suggest that mGluR5 amplifies the cellular response to a chemical signal, and that by blocking mGlur5 receptors in inhibitory neurons involved in depression, these new therapies can achieve an antidepressant effect,» says senior author Paul Greengard, Vincent Astor Professor and head of the Laboratory of Molecular and Cellular Neuroscience.

Bone loss in models of leptin or leptin receptor deficiency has been linked with lower osteoblast activity (9, 14), suggesting that cellular leptin resistance in obesity might reduce bone formation.

Aptamers are also being selected against specific cellular receptors for use in cancer therapy.

In situ hybridization on sections of gustatory ganglia (geniculate, petrosal / nodose) and a somatosensory ganglion (trigeminal) were performed to reveal serotonin receptor gene expression at the cellular level.

Adenosine A1 and A2 receptor agonists reduce endotoxin - induced cellular energy depletion and oedema formation in the lung

Our lab is interested in identifying the cellular and molecular mechanisms involved in the organization and maintenance of the synapse with a specific focus on the control of neurotransmitter receptor expression and localization.

These CARs contain two fused parts: an antibody that protrudes from the surface of a T - cell to recognise a protein on cancerous B - cells (commonly CD - 19) in the blood and a receptor inside the T - cell that sends messages to cellular machinery.

The Cell Surface Signalling Laboratory is interested in identifying new therapeutic targets for both genetic and infectious diseases by using large - scale systematic approaches to discover receptor - ligand interactions that are essential for cellular recognition processes.

Employing a combination of cellular, biochemical and genetic experiments, we showed that (i) human and murine pericytes express functional Tie2 receptor, (ii) Tie2 - silenced pericytes have a pro-migratory phenotype, (iii) Tie2 downstream signalling in pericytes involves Calpain, Akt and FOXO3A, (iv) Ng2 - Cre - driven deletion of pericyte - expressed Tie2 delays developmental angiogenesis and vessel maturation, and (v) Tie2 deletion in pericytes results in a pro-angiogenic tumour vasculature with enhanced tumour growth.

The lab's findings in the study, «D - serine Deficiency Attenuates the Behavioral and Cellular Effects Induced by the Hallucinogenic 5 - HT2A Receptor Agonist DOI,» suggested that D - serine - dependent NMDAR activity is involved in mediating the cellular and behavioral effects of 5 - HT2AR activation.

For instance, three scavenger receptor genes were suggested to facilitate the cellular uptake of carotenoids in the adductor muscles of orange - adductor Yesso scallop [13].

G protein - coupled receptors (GPCRs) are actually a huge protein family (i.e., superfamily) of transmembrane receptors that sense molecules outside Eukaryotic Cells in species ranging from yeast to humans, and activate very basic biological pathways and cellular responses inside the cells.

Nuclear accumulation of the AT < sub > 1 receptor in a rat vascular smooth muscle cell line: effects upon signal transduction and cellular proliferation.

LAMP2A: The A variant of lysosome - associated membrane protein 2 is a receptor involved in the cellular maintenance processes of autophagy, but levels decrease with age, and in at least some species this appears to be one of the factors involved in the age - related decline of autophagy.

In particular, the cAMP signaling cascade directs adaptive cellular responses to a variety of stress stimuli via a combination of acute affects arising from GS - protein coupled receptor (GPCR)- mediated activation of PKA and long - term affects resulting from transcriptional reprogramming directed by CREB and the CREB Regulated Transcription Coactivators (CTRCs).

Title: Expression of a1adrenergic receptors in rat prefrontal cortex: cellular colocalization with 5HT2A receptors Author: N. Santana et al..

This family of proteins is responsible for a vast array of cellular communication — including the light - sensing molecules in your retinas, the sugar sensors in your gut, and many of the neurotransmitter receptors that underlie the thoughts and emotions that move through your brain — and these proteins are the targets of the vast majority of pharmaceutical drugs.

Huntingtin null neurons exhibit a significant reduction in transcripts encoding proteins destined for the extracellular space, many of which are components of the extracellular matrix or involved in cellular adhesion, receptor binding and hormone activity.

In the worm, we are developing tools to monitor neuromodulation at cellular resolution in an intact brain and using them to directly measure endogenous peptide release and binding to receptors on identified neurons using real - time approaches for imaging neuropeptide signaling, in order to understand the dynamics of this process in a living animaIn the worm, we are developing tools to monitor neuromodulation at cellular resolution in an intact brain and using them to directly measure endogenous peptide release and binding to receptors on identified neurons using real - time approaches for imaging neuropeptide signaling, in order to understand the dynamics of this process in a living animain an intact brain and using them to directly measure endogenous peptide release and binding to receptors on identified neurons using real - time approaches for imaging neuropeptide signaling, in order to understand the dynamics of this process in a living animain order to understand the dynamics of this process in a living animain a living animal.

The process uses a computational model to generate predictions about the dynamics of cell receptors in different cellular compartments.

3/29/2007 UCSD Researchers Identify Critical Receptor in Liver Regeneration In studies in mouse models, researchers at the University of California, San Diego (UCSD) School of Medicine have found that A hepatic stellate cell activated by the p75 Neurotrophin Receptor promotes repair in the livera cellular recept... More.in Liver Regeneration In studies in mouse models, researchers at the University of California, San Diego (UCSD) School of Medicine have found that A hepatic stellate cell activated by the p75 Neurotrophin Receptor promotes repair in the livera cellular recept... More.In studies in mouse models, researchers at the University of California, San Diego (UCSD) School of Medicine have found that A hepatic stellate cell activated by the p75 Neurotrophin Receptor promotes repair in the livera cellular recept... More.in mouse models, researchers at the University of California, San Diego (UCSD) School of Medicine have found that A hepatic stellate cell activated by the p75 Neurotrophin Receptor promotes repair in the livera cellular recept... More.in the livera cellular recept... More...

Our strong expertise allows us study lipid - protein interaction based phenomena at different scales, from the organ and cellular systems down to minimal synthetic systems in which we can control the proteins as well as the lipid, for instance to monitor the allosteric effects of specific lipids on fundamental receptors such as the EGF receptor (Coskun et al (2011) PNAS) and the insulin receptor.

Molecules in the extracellular environment bind specifically to cell - surface receptors and trigger intracellular signaling, eventually leading to changes in cellular physiology.

The complex networks, interactions, and responses of immune cells produce diverse cellular ecosystems composed of multiple cell types, accompanied by genetic diversity in antigen receptors.

Upon ligand binding, the Gs - coupled GPCR receptor activates adenylyl cyclase that in turn produces cAMP, governing important cellular responses.

This bioidentical treatment provides the necessary boost in signal strength to growth hormone receptor cells throughout the body and the brain, stimulating metabolism, brain functions, immunity, cellular regeneration, libido, and more.

Insulin binds to many cells in the body having appropriate receptors for the peptide hormone and causes a general uptake in cellular glucose.

Over-inhibition of 5AR results in increased availability of testosterone, which may be shunted, via aromatase, to estradiol, causing «feminization,» e.g., gynecomastia, one of the side effects of 5AR inhibitor drugs; and decreased production of not only 5α - DHT, but its metabolites, 5α - Androstane - 3α - 17β - diol (aka 3α - adiol, a storage form of 5α - DHT), and 5α - Androstane - 3β - 17β - diol (aka 3β - adiol), an estrogen receptor beta (ERβ) ligand that promotes normal cellular differentiation, thus lessening risk of benign prostatic hypertrophy and prostate cancer.22, 23, 24

Aβ is believed to penetrate neuronal plasma membranes, where it leads to lipid peroxidation.10 It has also been implicated in deactivating a subunit of the pyruvate dehydrogenase complex, thereby inhibiting conversion of pyruvate to acetyl CoA and the eventual production of cellular energy as ATP.32 Another way Aβ affects glucose metabolism in the brain is that fragments of Aβ disrupt insulin signaling by binding to neuronal synapses, which alters their shape and function.15, 38 Insulin receptors are abundant at synapses, so if the integrity of the synapse itself has been compromised, the receptors won't function effectively.

Twelve - hour exposure of 3T3 - L1 adipocytes to H (2) O (2) or TNF - alpha resulted in the increase of c - Jun NH (2)- terminal kinase (JNK) activation and insulin receptor substrate 1 (IRS1) serine 307 phosphorylation, concomitantly with the decrease in insulin - stimulated IRS1 tyrosine phosphorylation and cellular glucose uptake.

Insulin is a hormone carrier that transports nutrients and glucose in the blood and binds them to cellular receptor sites.

The IV therapy consists of amino acids (the natural building block of protein) combined with vitamins and nutrients is administered intravenously in order to flood the brain, restoring neurotransmitters, manufacturing new neurotransmitters and receptors which promotes healing of the damaged area of the brain and allows for increased cellular energy production.

Moreover, since hormone receptors reside on the cellular membrane, a reduction in membrane inflammation makes the diet very effective for healing hormone - related conditions, including weight - loss resistance.

Diabetes results when either the islets cells of the pancreas lack the ability to secrete adequate levels of insulin in response to absorbed dietary glucose, or the cellular insulin receptors are unresponsive to insulin.

Either scenario may also occur due to refractoriness or exhaustion of the pancreatic islet cells and / or cellular insulin receptors due to obesity and diets overly rich in simple carbohydrates and fat.

Myasthenia gravis is caused by a reduction or deficiency in the number of cellular receptors for a specific neurotransmitter, acetylcholine, at the junctions between nerve endings and skeletal muscle cells.