Sentences with phrase «cellular responses»

Our study also suggests that cellular responses to future ocean conditions are not likely to be straightforward, as shifts in calcification may have less to do with calcification - related genes and more to do with intracellular regulatory processes in cells grown under continuous culture for many hundreds of generations.

Reactive oxygen species trigger cellular responses by activation of stress - responsive mitogen - activated protein kinase (MAPK) signalling pathways.

«Hormesis in aging is defined as «life - supporting beneficial effects resulting from the cellular responses to single or multiple rounds of mild stress.»

Analysis of cellular responses to free radicals: focus on exercise and skeletal muscle.

Increasing attention is being paid to mitochondrial dysfunction as a contributor to many diseases because these organelles lie at the cross roads of sensing and integrating cues from the environment to trigger adaptive and compensatory cellular responses.

Being in a ketogenic state has been shown to promote cellular responses that ultimately lower inflammation and oxidative stress and optimize energy metabolism.

By practicing specific yoga poses, we place certain amounts of therapeutic stress (called the «Goldilocks Position») on our connective tissues, gently creating tiny piezoelectric currents that in turn stimulate optimal cellular responses.

Multiple efforts are underway to characterize the humoral and cellular responses to vaccine candidates in our portfolio, including extensive systems - level analyses.

Certain particle compounds may directly generate ROS in vivo because of their surface chemistry (eg, metals, organic compounds, and semiquinones) or after bioactivation by cytochrome P450 systems (eg, polycyclic aromatic hydrocarbon conversion to quinones).6, 290 a, 290 b A particle surface or anions present on otherwise more inert particles may disrupt iron homeostasis in the lung and thereby also generate ROS via Fenton reactions.291 Other PM constituents may do so indirectly by the upregulation of endogenous cellular sources (eg, nicotinamide adenine dinucleotide phosphate [NADPH]-RRB- oxidase) 292,293 or by perturbing organelle function (eg, mitochondria) by taken - up PM components.261 Particle stimulation of irritant and afferent ANS fibers may also play a role in local and systemic oxidative stress formation.294 Given the rich antioxidant defenses in the lung fluid, secondarily generated oxidization products of endogenous molecules (eg, oxidized phospholipids, proteins) or a reduction in endogenous antioxidants per se may be responsible at least in part for the state of oxidative stress in the lungs (along with instigating the subsequent cellular responses) rather than ROS derived directly from PM and its constituents.

The hypoxia inducible factors (HIFs) integrate cellular responses to hypoxia.

I'm also interested in better understanding individual differences in responses to damages as well as differences in cellular responses, particularly stem cells.

It is increasingly recognized that spatial and temporal aspects of molecular interactions and activity are key for correct cellular responses.

Upon ligand binding, the Gs - coupled GPCR receptor activates adenylyl cyclase that in turn produces cAMP, governing important cellular responses.

(ii) the carbohydrates on the surface can serve as targeting molecules and trigger cellular uptake via specific receptors or mediate specific cellular responses [10].

Genotype correlations with the immune system as a whole, as well as with cellular responses to different stimuli, provides a valuable platform for the understanding of functional impact of disease associated variants.

RNA sequencing (RNA - seq) is a genomic approach for the detection and quantitative analysis of messenger RNA molecules in a biological sample and is useful for studying cellular responses.

Glycan functionalised NPs offer several advantages: (i) their synthesis can be performed under biomimetic conditions resulting later on in nanoparticles without traces of chemicals responsible for adverse cellular responses.

We are currently investigating the role of various T - cell costimulatory pathways in regulating the humoral and cellular responses to and between DENV and ZIKV, and are defining the particular pathways that should be targeted to maximize safety and efficacy of vaccines.

And there is no evidence that the vaccine will do what it is supposed to do — namely, provoke protective antibody and cellular responses to HIV.

In particular the cross talk between nervous and immune systems that coordinates behavioural and cellular responses to infection.

«For example, you could figure out patterns of toxicity of potential new drug compounds by looking at cellular responses and finding common responses to other known toxic molecules.»

Bethesda, Md., Thurs., Sept. 11, 2014 - Building on a successful three - year pilot project, the National Institutes of Health has awarded more than $ 64 million to six research institutions to create a database of human cellular responses, the Library of Integrated Network - based Cellular Signatures (LINCS).

A major challenge that will be addressed in the second phase of LINCS is to optimize the combinations of cell types, perturbations and measurements of cellular responses to address a wider range of basic biological and disease - related problems than was possible in the program's initial pilot stage, said Alan Michelson, M.D., Ph.D., senior investigator, Laboratory of Developmental Systems Biology, NHLBI, and co-chair of the NIH LINCS Project Implementation Team.

Hydrogen peroxide and other ROS mediate cellular responses in aging and myriad common chronic diseases, including diabetes, heart disease, stroke, cancer, and neurodegeneration.

Systems biology aims to study complex cellular systems by systematically stimulating them, monitoring cellular responses, formulating mathematical and computational models to understand the data, and proposing new experiments to refine these models.

The major portion of our research is aimed at elucidating fundamental mechanisms that regulate protein folding and the cellular responses to the accumulation of unfolded protein within the (ER).

Live cell assays constructed with genetically encoded, fluorescent biosensors can provide significant advantages over endpoint assays measured in cell lysates because functional information about the timing and location of cellular responses can be monitored in cells that are relevant to disease.

Still, the rewards far outweigh the frustrations, as an understanding of allostery can lead to the physical control of molecular switches and downstream cellular responses.

The Kaufman lab is focused on understanding the fundamental mechanisms that regulate protein folding and the cellular responses to the accumulation of unfolded proteins within the Endoplasmic Reticulum (ER).

The emerging insights into cnidarian genomics also provides the opportunity to develop an array of tools that can be applied to better understand the physiology, molecular biology and cellular responses of coral.

On the other hand, histidine kinases allow bacteria, plants, and fungi to sense and respond to their environment, regulating a number of cellular responses such as osmoregulation, chemotaxis, sporulation and microbial pathogenesis (37).

Optical imaging provides another poweful approach for detection of pathogen and host cellular responses in real - time.

Rassf1A null fibroblasts did not show increased sensitivity to microtubule poisons or DNA - damaging agents and showed no evidence of gross genomic instability, suggesting that cellular responses to genotoxins were unaffected.

In particular, the cAMP signaling cascade directs adaptive cellular responses to a variety of stress stimuli via a combination of acute affects arising from GS - protein coupled receptor (GPCR)- mediated activation of PKA and long - term affects resulting from transcriptional reprogramming directed by CREB and the CREB Regulated Transcription Coactivators (CTRCs).

Inhibition of cellular responses to insulin in a rat liver cell line.

Veto - like activity of mesenchymal stem cells: functional discrimination between cellular responses to alloantigens and recall antigens.

Processing of polycaprolactone and polycaprolactone - based copolymers into 3D scaffolds, and their cellular responses.

G protein - coupled receptors (GPCRs) are actually a huge protein family (i.e., superfamily) of transmembrane receptors that sense molecules outside Eukaryotic Cells in species ranging from yeast to humans, and activate very basic biological pathways and cellular responses inside the cells.

Imaging mismatch repair and cellular responses to DNA damage in Bacillus subtilis.

Transcriptional regulatory networks in cellular responses and tolerance to dehydration and cold stresses.

We will evaluate the immunogenicity of vaccine candidates (provided by user) administered by systemic, transdermal or mucosal routes and will monitor humoral responses and cellular responses.

UNISI will investigate whether the magnitude of antigen - specific cellular responses generated after priming can predict the secondary humoral response.

In NHPs specifically also BCG will be evaluated as a gold standard and benchmark vaccine inducing cellular responses for comparison to human data.

The cell density of cartilage is also very low, therefore, cell cultures offer an easier approach to study cellular responses of chondrocytic cells, e.g., to mechanical stimuli.

«Lots of things bind to heparan sulfate to trigger various cellular responses, but when active heparanase levels are high, the receptors become degraded, so bound molecules are released and can cause damage to the local tissues,» said Agelidis.

levels, and their immune responses to the SGE were more likely to be Th2 - type cellular responses.

Tucked into the internal surface of the cell's outer membrane, these versatile molecules coordinate cellular responses to a multitude of signals that impinge from without

They found that both D - GLP1 and D - PTH elicited cellular responses similar to their natural counterparts but had a longer - lasting effect.

Researchers at the University of California, San Diego School of Medicine have, for the first time, described the sequence of early cellular responses to a high - fat diet, one that can result in obesity - induced insulin resistance and diabetes.

The scientists also found that the cellular responses persisted long after each of the photographs disappeared, further suggesting that the amygdala cooperates with other brain regions to create awareness of the emotional content of faces.