Sentences with phrase «cellular signalling pathway»

Once there, the protein acts on the osteoblasts and inhibits Wnt activity, which is a cellular signalling pathway that is involved in the formation of the skeleton and in certain disorders, such as osteoporosis, arthritis and myeloma.

«This occurs when CSN6 is deregulated through a series of cellular signaling pathways.»

The transcription of non-coding regions in the genome is precisely regulated by cellular signaling pathways — and on a grand scale: up to 80 per cent of the RNA copies were non-coding.

Meanwhile, cancer genome projects have yielded unprecedented insights into the cellular signaling pathways that drive the development and progression of cancer — information that has led to effective therapies tailored for individual patients.

This landmark revelation was the first definition of an entire cellular signaling pathway from the cell surface to the nucleus, providing an important paradigm for understanding intracellular signaling.

Sirtuins are enzymes regulating the expression of genes that control the function of cells through key cellular signalling pathways.

The present review describes the cellular signalling pathways regulating mammalian autophagy and highlights the potential therapeutic application of autophagy inducers in neurodegenerative disorders.

Study identifies cellular signaling pathway that enables breast cells to resist tissue changes during tumor development and is associated with better prognosis

In addition to their antioxidant properties, these polyphenolic compounds exhibit neuroprotective properties by their interaction with cellular signaling pathways followed by transcription and translation that mediate cell function under both normal and pathologic conditions.

ln hOSA, the Hedgehog (HH) developmental and cellular signaling pathway has been documented to contribute to the pathogenesis of the disease, impacting genes responsible for tumor formation and metastasis.

Researchers uncovered evidence that a common cellular signaling pathway is associated with aggressive hemangiosarcoma tumor growth and chemotherapy resistance.

Not exact matches

When mutated, BRAF, an enzyme that acts in a signaling cascade known as the MAPK / ERK pathway, becomes overactive and leads to increased cellular growth, a hallmark of cancer.

The AXIN2 protein interacts with proteins in the Wnt signalling pathway, which is involved in controlling many cellular processes, including development.

In addition to diminishing the tumor's energy supply, the diet slows the growth of glioblastoma cells by altering a cellular - signaling pathway that commonly occurs in cancers, according to the researchers.

Through the mTOR signalling pathway, it is involved in the regulation of many cellular processes, including cell survival, metabolism, proliferation, differentiation, and senescence.

Rapamycin, which is an inhibitor of the mammalian target of rapamycin (mTOR) signaling pathway, has a variety of cellular functions and is known to possess both immunosuppressant and anti-tumor properties.

«The mechanism we demonstrated is the most sensitive cellular thermometer known to date, since the signaling pathways that trigger a heat shock or cold shock hardly react in this physiologically relevant temperature range,» explained Prof. Dr. Florian Heyd.

Gamma secretase inhibitors tend to produce adverse effects by interacting with Notch, an important pathway for cellular signaling.

Among their many functions, signaling pathways regulate biological processes required for cellular survival.

This study reveals how lipids control SH2 domain - mediated cellular protein interaction networks and suggests a new strategy for the therapeutic modulation of pY - signaling pathways.

«Almost nothing is known» about the molecular and cellular mechanism by which water is detected in the mouth and throat, and the neural pathway by which that signal is transmitted to the brain, says Zachary Knight, a neuroscientist at the University of California, San Francisco.

«The mineral zinc acts as a catalytic, structural and signaling factor in the regulation of a diverse array of cellular pathways involving hundreds of enzymes and proteins,» he said.

Hokkaido University researchers have uncovered a cellular protein that stabilizes a tumor promoting signaling pathway, suggesting a new target to treat prostate cancer.

A team of researchers led by Professor Lindsay Hinck at the University of California, Santa Cruz, examined the ROBO signaling pathway in breast epithelial cells and found that one family member, ROBO1, enhances cellular contractility and stimulates assembly of cell - matrix adhesions.

Researchers also know that a cellular pathway called the Wnt signaling pathway induces hair growth.

My lab is investigating the normal cellular functions of signaling pathways implicated in neurological disease, with an emphasis on axon growth and guidance.

Multiple effects of a novel epothilone analog on cellular processes and signaling pathways regulated by Rac1 GTPase in the human breast cancer cells.

We use neuronal cultures, induced pluripotent stem (iPS) cells and transgenic and gene - targeted mouse models to study the differential effects of apoE3 and apoE4 on cell signaling pathways and cytoskelatal structure and function at molecular, cellular and behavioral levels.

Numerous studies have demonstrated activity of these agents against a wide variety of cancers, especially cancer stem cell - like subpopulations, by a host of different mechanisms which comprise inhibition of signaling pathways, of mitochondrial respiration, as well as of cellular stress responses and others.

The accumulation of calcium can then regulate the contraction of muscles, trigger the release of neurotransmitters or hormones, modulate intracellular signaling pathways, and impact several other calcium - dependent cellular functions.

Wnt / beta - catenin signaling is a tightly regulated, multi-functional pathway involved in in many cellular processes, including cellular decisions about proliferation versus differentiation.

Using DOS and small - molecule screening, Schreiber helped illuminate many cellular pathways, including the nutrient - response signaling network involving TOR proteins in yeast and mTOR in mammalian cells.

Cancerisation can result from perturbations at each of these levels and is linked to misregulation of developmental signalling pathways, uncontrolled cellular proliferation and a loss of cellular identity.

Kontoyiannis D., Boulougouris G., Manoloukos M., Armaka M., Apostolaki M., Pizarro T., Kotlyarov A., Forster I., Flavell R., Gaestel M., Tsichlis P., Cominelli F., Kollias G., 2002, «Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor - induced Crohn's - like inflammatory bowel disease», JEM, 196, 1563 - 74.

Countering the prevailing theory that cellular hydrogen peroxide signaling is broad and non-specific, Whitehead Institute scientists have discovered that this reactive oxygen species (ROS) in fact triggers a distinct signal transduction cascade under control of the mitochondrial respiratory chain — the Syk pathway — that regulates transcription, translation, metabolism, and the cell cycle in diverse cell types.

Examples of these include cell proliferation, intracellular targeting, cell polarity, membrane traffic, cell migration, stem cell biology, chromatin regulation and function, differentiation, morphogenesis and biomechanics, and regeneration and cellular homeostasis, as well as developmental roles of genes, cellular structural dynamics, and signaling pathways.

At the cellular level, p53 can either induce senescence or, of major interest here, inhibit senescence by controlling both reactive oxygen species (ROS) levels and a signaling pathway mediated by protein kinases AMPK and mammalian target of rapamycin (mTOR).

Our goal is to identify signaling pathways which control or coordinate these different phenotypic transitions and to evaluate how these pathways can be influenced by the cellular environment, altered in pathological contexts or serve as therapeutic targets.

Signalling cascades, such as the Wnt, TGF - β, Notch and Hedgehog pathways, pattern embryos by specifying cellular identity and coordinating morphogenetic events.

Studies on the effects of GHRH antagonists on prostate and lung cancers demonstrated their ability to modulate signaling pathways involved in cellular proliferation, survival, metastasis, and apoptosis.

The Buck's Kennedy is conducting research on cell - signaling pathways, in particular the mTOR pathway, which senses cellular nutrients, oxygen and energy levels and tells cells whether to grow, divide or stop.

While signaling pathways have been mapped in detail, molecular and cellular determinants governing signal propagation across the membrane have remained controversially debated.

When an acute injury has taken place, the cellular inflammatory pathways signal the body to send red and white blood cells to the injured area in order for healing to take place.

It outlines a clear chain of cellular events, from the binding of DNA, through a specific signaling pathway, to the reduction of proteins known to trigger inflammation.»

Ji LL, Gomez - Cabrera MC, Vina J. Exercise and hormesis: activation of cellular antioxidant signaling pathway.

It inhibits anabolic signaling pathways when cellular ATP levels are decreased and AMP levels increase in response to limited energy availability (31).

Although certain elements of these intricate signaling pathways independently modulate critical steps involved in the cellular control of skeletal muscle anabolism and proteolysis, commonality between pathways does exist.

Reactive oxygen species trigger cellular responses by activation of stress - responsive mitogen - activated protein kinase (MAPK) signalling pathways.