Sentences with phrase «cellular stress such»

In response to cellular stress such as DNA damage, oncogene activation, transcriptional inhibition, and hypoxia, tumor suppressor p53 is activated and expressed, and acts as a transcription factor to induce its target genes [1], thereby playing a central role in the regulation of DNA repair, cell cycle, apoptosis, senescence, and angiogenesis [2 - 4].

Not exact matches

Findings based on this new technology are likely to have a significant impact on basic cellular research and increase our knowledge of how cells work and respond to stresses, such as exposure to contamination.

To coordinate their size and growth with current environmental conditions, cells rely on the mechanistic target of rapamycin complex 1 (mTORC1) pathway, which senses cellular stresses, growth factors, and the availability of nutrients, such as amino acids and glucose.

However, since folding and maintaining of such structures is highly sensitive to cellular or environmental stress, proteins can potentially misfold or form clumps (aggregates).

Scientists have known that, in organisms ranging in complexity from yeast to humans, different kinds of cellular stress — such as a backlog of unfolded proteins, DNA - damaging UV light, a shortage of the amino acid building blocks needed to make protein, viral infection, iron deficiency — trigger different enzymes to act downstream to switch off eIF2 alpha.

â $ œIt is well known that the immune system can detect and respond to pathogens, but these results highlight its capacity to sense and adapt to environmental changes, such as nutritional starvation, which cause cellular stress, â $ he says.

Enhanced amyloidogenic processing of APP by the ß - site APP cleaving enzyme (BACE) and the γ - secretase complex and reduced clearance lead to increased intracellular levels of soluble oligomeric Aß, resulting in cellular dysfunction comprising e.g., synaptic failure, mitochondrial dysfunction, enhanced oxidative stress, neurotransmitter and neurotrophin depletion, inflammation, and apoptosis which is reflected in patients as clinical symptoms such as cognitive deficits [2, 3].

A multitude of plant hormetic compunds such as polyphenols, flavanols, luteolin, apigenin, anthocyanins, and pterostilbene — these compounds actually induce a small stress response in our cells which build cellular resilience and health

NF - κB is a responsive protein complex, which means its job is to respond to cellular stimuli, such as stress, free radicals, and antigens.

1) A micronutrient sufficiency test such as Genova NutrEval or the SpectraCell test for vitamin, mineral, and essential fatty acid deficiencies, digestive support, antioxidant status, short - term toxic element exposure, and markers of oxidative stress and cellular damage such as lipid peroxides and 8 - hydroxydeguanosine (8 - OHdG).

[7] Amino acids also contribute to cellular energy metabolism by providing a carbon source for entry into the citric acid cycle (tricarboxylic acid cycle), [8] especially when a primary source of energy, such as glucose, is scarce, or when cells undergo metabolic stress.

behind the helpful effects of restricting calories, such as improved cellular turnover and hormonal balance and reduce oxidative stress, leading to anti-aging effects.