Sentences with phrase «cellular studies in»

Molecular, subcellular and cellular studies in whole animals or humans; and novel molecular, immunological or biophysical studies of hormone action are also featured.

Not exact matches

In the study, mice were given food until they became obese, and were then fed the drug, which increases the cellular metabolism of obesity - linked white fat cells.

Studies have shown that dieting in pregnancy changes your unborn child at the cellular level.

During this clinically silent period, however, there may be indicators of dysfunction on a cellular level, such as the elevated levels of S100B antibody found in the cerebral spinal fluid in the football players in the study, even six months after the end of the season, which he said, could «potentially herald -LSB--RSB- the early stages of [chronic traumatic encephalopathy] or CTE.»

The disruption of prenatal cellular activity in zebra fish, which share 80 percent of their genes with humans and are considered a good model for studying human brain development, seemed to result in hyperactivity, according to the Canadian study, which was published Monday in the Proceedings of the National Academy of Sciences.

Free fatty acids created during the digestion of infant formula cause cellular death that may contribute to necrotizing enterocolitis, a severe intestinal condition that is often fatal and occurs most commonly in premature infants, according to a study by University of California, San Diego bioengineers.

Boivin had studied cellular, molecular, and microbial biology for her Bachelor of Science degree at the University of Calgary in her native Canada, but, she says, «I always had an interest in archaeology.»

In their years - long quest to understand the cellular and genetic mechanisms that may trigger SUDEP, Noebels and his colleagues have studied the genes that are involved in the heart beaIn their years - long quest to understand the cellular and genetic mechanisms that may trigger SUDEP, Noebels and his colleagues have studied the genes that are involved in the heart beain the heart beat.

As in cellular assays, the animal studies have shown that drug treatment leads to improvement in nuclear gem / Cajal body numbers in motor neurons.

In conclusion, this new study identifies the cellular origin of Pik3ca - induced tumours and reveals that oncogenic Pik3ca activates a multipotent genetic program, setting the stage for future intratumoural heterogeneity at the earliest stage of tumor development.

They studied the bone metabolism at the cellular level using advanced imaging and computational techniques, which allowed them to identify 142 metabolites that were significantly altered by more than 1.5 times in the diabetic mice.

I first became aware of bioinformatics while in graduate school at the University of Colorado, Boulder, studying molecular, cellular, and developmental biology.

So in 1974, he headed south to Tulane University in New Orleans, Louisiana, for graduate training in physiological psychology: the study of how the brain influences behavior at the neurochemical and cellular levels.

In a new study researchers have investigated the associations between office type (cellular office, shared - room office, small open - plan office, and medium - sized open - plan office) and employees» job satisfaction, well - being, and ease of interaction with co-workers.

Now 24, he is a first - year graduate student in the department of cellular and structural biology at the University of Texas Health Science Center in San Antonio (UTHSCSA), where he is studying the role of oxidative damage — the wear and tear inflicted upon the cell by toxic molecules called free radicals — in the aging process.

Clinically important findings suggest that targeting the epidermal growth factor receptor (EGFR) and the fibroblast growth factor receptor (FGFR) cellular pathways may benefit thousands of patients with this disease, according to the study published today in the journal PLOS Genetics.

Scientists have rolled back time for live mice through systemic cellular reprogramming, according to a study published December 15 in Cell.

In this new study published in Nature, Alexandra Van Keymeulen and colleagues used state of the art genetic mouse models to identify the cellular origin of PIK3CA and p53 induced breast tumorIn this new study published in Nature, Alexandra Van Keymeulen and colleagues used state of the art genetic mouse models to identify the cellular origin of PIK3CA and p53 induced breast tumorin Nature, Alexandra Van Keymeulen and colleagues used state of the art genetic mouse models to identify the cellular origin of PIK3CA and p53 induced breast tumors.

«Finding these similarities and studying the aspects of mouse biology that may reflect human biology, allows us to approach the study of human illnesses in a better way,» affirms Bing Ren, one of the principal authors from the ENCODE Consortium and a lecturer in molecular and cellular medicine at the University of California — San Diego.

Now, in this week's issue of the Proceedings of the National Academy of Sciences, Thomas Albright and Ricardo Gil - da - Costa of the Salk Institute for Biological Studies describe a model system that completes the bridge between cellular and human studies of schizophrenia, an advance that should help speed the development of therapeutics for schizophrenia and other neurological disStudies describe a model system that completes the bridge between cellular and human studies of schizophrenia, an advance that should help speed the development of therapeutics for schizophrenia and other neurological disstudies of schizophrenia, an advance that should help speed the development of therapeutics for schizophrenia and other neurological disorders.

But there are also certain things that if an investigator like [s] to do, and I came from cellular neurobiology having learnt from Grundfest and from Wade Marshall and from my period at the NIH how to study nerve cells in the brain; and I was until that point studying complex organisms — a cat; Aplysia fitted me to a tee.

«Our study contributes to an improved understanding of how cellular metabolism plays an important role in the acquisition of resistance to certain therapeutic agents,» said Sérgio Dias.

And once I got into brain biology, it became clear you needed to study the brain on the cellular level, and once you began to understand aspects of behavior in the cellular level, you wanted to understand the molecular level.

«The technology has applications in chemical analysis, environmental monitoring, medical diagnostics and cellular studies,» says Wang.

Sheng Ding, PhD, a senior investigator in the Roddenberry Stem Cell Center at Gladstone and co-senior author on the study, adds, «This new cellular reprogramming and expansion paradigm is more sustainable and scalable than previous methods.

Purdue University physicists are part of an international group using spinach to study the proteins involved in photosynthesis, the process by which plants convert the sun's energy into carbohydrates used to power cellular processes.

Because they act while embedded within the cellular membrane, transmembrane proteins have proven to be more difficult to study than proteins that operate in the watery solution that make up the cells» cytoplasm or in the extracellular fluid.

But pioneering studies showed that molecular bric - a-brac could be added to DNA in adulthood, setting off a cascade of cellular changes resulting in cancer.

«Our study is a nice example of how the understanding of a disease on the molecular and cellular level results in new therapeutic options.

The new study, published in Nature Communications, also presents significant advancements in cellular reprogramming technology, which will allow scientists to efficiently scale up pancreatic cell production and manufacture trillions of the target cells in a step-wise, controlled manner.

In their study, the Salk scientists sought to determine precisely how the mutated WRN protein causes so much cellular mayhem.

With Gazzaley's background in cellular and systems neurobiology, «Adam's going to bring a lot of that expertise to his imaging studies,» Morrison says, and is well - positioned to make important contributions.

For instance, Dawson says, Autism Speaks is funding studies investigating the idea that disorders in the cellular powerhouses, mitochondria, might influence responses to immune challenges such as infection and immunization.

New findings published in the Proceedings of the National Academy of Sciences showed in lab studies that supplementing an epigenetic cancer drug called decitabine with vitamin C enhanced the drug's ability to impede cancer cell growth and trigger cellular self - destruction in cancer cell lines.

He hopes to pursue projects such as developing therapeutics with chemists, working with biophysicists to study protein conformational changes relevant to viral entry into the cell, and investigating cellular trafficking pathways relevant to the viral life cycle in collaboration with cell biologists.

In a process called cellular reprogramming, researchers at Icahn School of Medicine at Mount Sinai have taken mature blood cells from patients with myelodysplastic syndrome (MDS) and reprogrammed them back into iPSCs to study the genetic origins of this rare blood cancer.

Izpisua Belmonte added that more extensive studies will be needed to fully understand the role of heterochromatin disorganization in aging, including how it interacts with other cellular processes implicated in aging, such as shortening of the end of chromosomes, known as telomeres.

The NRC panel, chaired by neurobiologist Charles Stevens of the Salk Institute in La Jolla, California, looked at more than 500 human, animal, and cellular studies on EMFs and found «no conclusive and consistent evidence... that exposures to residential electric and magnetic fields produce cancer, adverse neurobehavioral effects, or reproductive and developmental effects.

Cell lines are the workhorses of biology, routinely stocked and studied in every laboratory to understand cellular pathways, receptors, targets, hormones, and all aspects of normal and malignant physiology.

In another application, the sensor was used to study how cells respond to the introduction of extracellular hydrogen peroxide, which produces a wave of oxidation as it moves through the cellular structures.

«Proper blood cell production is dependent on functioning hematopoietic stem and progenitor cells that are destroyed during conditioning procedures for transplantation or following bone marrow injury,» said the study's first author Kevin A. Goncalves, who performed this research as part of his PhD studies in cellular and molecular physiology at the Sackler School.

With the discovery of ZBTB48's novel linkage between telomeres and mitochondria, which both have key roles in cellular ageing, we will also be studying whether this interplay contributes to telomere maintenance.»

«To date, there has been no systematic means of assessing the fidelity of cellular engineering — to determine how closely cells made in a petri dish approximate natural tissues in the body,» says George Q. Daley, MD, PhD, Director of the Stem Cell Transplantation Program at Boston Children's and senior investigator on both studies.

Less studied is the genesis of iron - sulfur clusters, the active core in enzymes that drive almost every aspect of cellular chemistry.

«Laminins function as attractive chemical cues for haptotaxis of axonal growth cones,» explains NAIST Prof. Naoyuki Inagaki, whose lab studies how forces are generated in the cellular microenvironment to create directed axonal migration.

Their study is the first of its kind in the ear field and helps resolved the molecular aspects of the cellular complexity of the inner ear.

In the more recent study, cellular changes began to reverse themselves when the mice's ears were unplugged.

The changes in cellular structure and behavior were the opposite of what Xu - Friedman team's saw in a previous study that placed mice in a consistently noisy environment.

Lydia Villa - Komaroff, a molecular and cellular biologist and co-founding member of the Society for the Advancement of Chicanos / Hispanics and Native Americans in Science, underscored the value of basic research, noting that her work studying strains of infection - resistant bacteria led to a discovery that «made it possible to make insulin and other treatments in bacteria.

Obesity suppresses an important cellular process that prevents kidney cell damage, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN).