Sentences with phrase «cellular targets for»
His lab is currently investigating the organization and function of a vastly underexplored but potentially highly important neural pathway from the cholinergic MT to DA neurons, and seeking potential causes, as well as molecular and cellular targets for treating schizophrenia.
https://www.salk.edu/
Our results identify cellular targets for future functional investigations, and demonstrate that connectomes can provide key insights into neuronal computations.
Wahl was on the tenure track in 2002 as a pathology researcher at Duke University, identifying cellular targets for cancer therapies, when funding dried up for her research and she consequently failed to get tenure.
Not exact matches
«Innovative genetic, cellular techniques help identify multiple disease targets: CRISPR - Cas9 and iPSC advances hold treatment promise for schizophrenia, addiction, Zika infection and other diseases.»
Called mTOR in mammals, for the term «mammalian target of rapamycin,» this pathway has a critical evolutionary value — it helps an organism avoid too much cellular expansion and growth when energy supplies are insufficient.
When cells become cancerous, tremendous stresses are placed on the cellular machinery responsible for maintaining protein equilibrium — and that machinery is the target of anti-cancer drugs called proteasome inhibitors.
This opens up the possibility for the production and use of sentinel circuits, which produce other bioactive compounds in response to environmental or cellular changes, to target a range of diseases including cancer.»
Lung cancer causes the most cancer - related deaths in the United States, and researchers are searching for new cellular targets to increase survival rates.
«Alcohol prevents ability to extinguish fearful memories in mice: Insight into cellular mechanisms illuminates biological target for PTSD therapy.»
In response to cellular stress that can cause cancer, the team found that LC3, chromatin, and laminB1 migrate from the nucleus — via the nuclear blebs — into the cytoplasm and are eventually targeted for disposal.
«The goal of our work is to understand the cellular mechanisms responsible for beta cell destruction so that we can identify the best targets for beta cell protection,» Costes said.
But Skalak says Allen intends to fund such established scientists» work in «wholly new» areas: Doudna, for example, will explore a new mechanism to edit cellular function by targeting RNA.
Taken together with the fact that several cellular target are addressed, this could provide a novel approach for tuberculosis treatment.
Future work will focus on identifying cellular targets of ampulexins, and potentially generating a useful animal model for the study of Parkinson's disease treatments.
«The structure of kinesin - 5 is unexpected, and the implications are big — it allows us to target it, for example in various forms of cancer,» said Jawdat Al - Bassam, assistant professor of molecular and cellular biology at UC Davis, who led the project.
The role of academic scientists in this process has largely been to explain the genetic / cellular basis of diseases for identifying useful targets and provide new chemical and computational methods to improve the pharmacological profile of potential drugs.
«It would be very difficult for the virus to develop resistance against a therapy that targets a cellular protein,» says Palese.
Known as much for its complexity as its vital role in regulating cellular and organismal growth, the mechanistic target of rapamycin complex 1 (mTORC1) pathway has seemingly been acting in mysterious ways.
Caribou Biosciences, a developer of technology - based solutions for cellular engineering, today announced that it entered into a collaboration agreement with Novartis under which the two companies will utilize Caribou's proprietary CRISPR - Cas9 platform to research new CRISPR - based drug target screening and validation technologies.
For example, cellular reprogramming is an inefficient process because many of the target areas on the genome are covered by other proteins, like a childproof cap on a medicine bottle, which prevents the reprogramming factors from binding there.
The Cell Surface Signalling Laboratory is interested in identifying new therapeutic targets for both genetic and infectious diseases by using large - scale systematic approaches to discover receptor - ligand interactions that are essential for cellular recognition processes.
She is currently studying the cellular and genetic mechanisms of liver cancer with the hope of identifying new biomarkers and drug targets for this often fatal disease.
The Cell Surface Signalling Laboratory investigates the molecular basis of cellular recognition processes to identify new therapeutic targets for both genetic and infectious diseases.
The lab focuses on clarifying the mechanisms of brain plasticity, gene expression, and responses of cellular elements to different psychotropic drugs, and have identified several novel brain sites and pathways that constitute attractive targets for new drug development.
The targets for this suppression are DC, CD4 + Th, CD8 + CTL and NK cells; in effect MSC silence each aspect of the cellular rejection process.
We are interested in topics ranging from how membranes contributed to the origin of cellular life, to identifying membrane - based targets for antibiotic resistance.
For nearly all the genetic mutations and resulting cellular mix - ups that have been chronicled, no drug exists to target that root cause.
This family of proteins is responsible for a vast array of cellular communication — including the light - sensing molecules in your retinas, the sugar sensors in your gut, and many of the neurotransmitter receptors that underlie the thoughts and emotions that move through your brain — and these proteins are the targets of the vast majority of pharmaceutical drugs.
The cellular processes that we have identified in this study as being important for the development of stomach cancer provide new targets for therapy that have not been explored before,» Dr. O'Reilly said.
Establishing the role of cigarette smoke in progression of cancer will not only produce the necessary evidence for implementing smoking cessation interventions but may also help to identify cellular mechanisms for therapeutic targeting.
To further characterize HPP - 4382, we screened a selection of alternative genes for expression: two markers of endoplasmic - or general cellular stress, HSPA6 and GADD45A, and ICAM1, a target of NF - B.
He has made several important contributions in this area including identifying a new strain of CHIKV virus, identification of host cellular targets of HIV accessory genes, new novel DNA vaccine approaches for HIV, CHIKV, RSV, Dengue, MERS and Zika among others.
By uncovering the precise cellular mechanisms of nicotine's effect, this study suggests new and more precise targets for drugs designed to block this powerful craving.
With DriverMap, Cellecta offers a novel, comprehensive end - to - end service portfolio for identifying differential gene expression, mapping of clinically actionable mutations in RNA, detecting cellular composition, and profiling immunotherapy targets.
The restriction of cellular growth by p53 has been reported to result in cell cycle arrest or apoptosis [6], and targeting p53 and restoring p53 function to limit tumor growth has been intensively researched for cancer therapy [7].
Like a pair of molecular scissors, CRISPR enables scientists to target a stretch of cellular DNA for alteration.
Identification of cellular targets of microRNA - 181a in HepG2 cells: a new approach for functional analysis of microRNAs
It reveals that targeted treatments for acute promyelocytic leukaemia, a rare form of blood cancer, cause a cascade of molecular events leading to cellular senescence and recovery.
Targets of research range from basic molecular and cellular mechanisms, the manipulation of these mechanisms in animal models, analyses of the genes and gene products in cardiovascular disease, and clinical research that seeks to improve diagnosis and therapy for patients.
Therefore, the identification of cellular and molecular mechanisms underlying neuron - astrocyte communication will help to a better understanding of the mechanisms of brain phsyiology as well as to appropriately identify cellular targets to direct therapeutic approaches for the future treatment of several brain diseases.
Therefore, we hypothesized that NSCs could serve as an ideal cellular delivery platform for targeting antibodies to malignant tumors.
As a monolayer of cells critical to photoreceptor function and survival, the RPE is an ideally accessible target for cellular therapy.
Because the cellular fraction contained proteins destined for degradation in addition to enzymes required for the reaction, the team began to suspect that APF - 1 was linked to degradation targets rather than to the proteases that destroyed them.
BETHESDA, MD, — The Foundation for the National Institutes of Health (FNIH) has selected Whitehead Institute Member David Sabatini to receive its fifth annual Lurie Prize in Biomedical Sciences for discovery of the mTOR (mechanistic target of rapamycin) cellular pathway as a key regulator of growth and metabolism in response to nutrients.
While Target undoubtedly earned little money off of individual Kindle device sales, the Kindle line was their bestselling tablet / eReader this past holiday season and it is almost impossible to actually use a Kindle for showrooming given that even the Kindle Fire lacks a camera and cellular connectivity.
Antidepressants block the «reuptake» system so that serotonin or other targeted neurotransmitters remain available for cellular use.
The Cellular Telecommunications and Internet Association, a trade group for the cellular industry, responded with a call for public education on cellular use while driving as well as for stricter enforcement of existing laws that target unsafe driving practices.