Sentences with phrase «cellular targets in»

Therefore the group studies with sophisticated imaging technology in vitro and ex vivo: i) the molecular mechanism driving the migration of HIV through the intestinal epithelial barrier; ii) the cellular targets in the mucosa, in specific macrophages and DCs, to identify the possible pathways to invade the tissue and disseminate to other organs; iii) the involvement of DCs and their functional properties in mediating adaptive immune responses at mucosal level; and iv) the role of antibodies with different effector functions in changing the pathways of the virus.

In addition, there were no signs that the engineered T cells caused side effects by hitting the wrong cellular targets in the mice.

Another Bristol - Myers Squibb experimental compound can be taken orally but isn't very selective in terms of its cellular targets in the body.

Howard Hughes Medical Institute researchers chiseling away at the problem of antibiotic resistance now have a detailed explanation of how the drugs» main cellular target in bacteria evolves to become...

Not exact matches

Clinically important findings suggest that targeting the epidermal growth factor receptor (EGFR) and the fibroblast growth factor receptor (FGFR) cellular pathways may benefit thousands of patients with this disease, according to the study published today in the journal PLOS Genetics.

The organizers, including researchers from Frankfurt, expect that many cellular functions of membrane lipids will be revisited from a new perspective and that it will be possible to support hormone - producing cells in a more targeted manner.

Given the importance of ATP synthase in fueling the cell, determining the complete structure of the enzyme has been a scientific holy grail, promising to reveal secrets about the ATP machine that could lead to therapeutic target identification and advance understanding of metabolic disease and other cellular pathologies.

Called mTOR in mammals, for the term «mammalian target of rapamycin,» this pathway has a critical evolutionary value — it helps an organism avoid too much cellular expansion and growth when energy supplies are insufficient.

There he worked on anticancer vaccines, identifying drug targets, preparing vaccine formulations, and testing cellular responses in vaccinated patients.

In the future, she adds, «we might be able to alter the course of brain development» with drugs targeted at the cellular anomalies and delivered during pregnancy.

Gene Yeo, a professor of cellular and molecular medicine at UCSD, led the research and showed he could target RNA in living cells, a first step toward treating diseases like muscular dystrophy and neurodegeneration.

This opens up the possibility for the production and use of sentinel circuits, which produce other bioactive compounds in response to environmental or cellular changes, to target a range of diseases including cancer.»

The new study, published in Nature Communications, also presents significant advancements in cellular reprogramming technology, which will allow scientists to efficiently scale up pancreatic cell production and manufacture trillions of the target cells in a step-wise, controlled manner.

Using the same computer - based approach, the team has now been able to target the c - FLIP (cellular FLICE [FADD - like IL - 1β - converting enzyme]- inhibitory) protein, known to play a key role in cancer stem cell maintenance and survival, described in previously published work by the Institute.

Cell lines are the workhorses of biology, routinely stocked and studied in every laboratory to understand cellular pathways, receptors, targets, hormones, and all aspects of normal and malignant physiology.

Lung cancer causes the most cancer - related deaths in the United States, and researchers are searching for new cellular targets to increase survival rates.

The drug targets a specific cellular process that occurs in animals, including humans, delaying the onset of age - related deaths by slowing the aging process.

«Alcohol prevents ability to extinguish fearful memories in mice: Insight into cellular mechanisms illuminates biological target for PTSD therapy.»

Many of those efforts have focused on drugs that target cellular receptors in the brain called NMDA receptors.

In response to cellular stress that can cause cancer, the team found that LC3, chromatin, and laminB1 migrate from the nucleus — via the nuclear blebs — into the cytoplasm and are eventually targeted for disposal.

He predicts that the discovery will help researchers develop very specific anti-inflammatory drugs that can subtly tweak the body's immune responses by targeting distinct ubiquitin ligases and similar enzymes involved in cellular garbage disposal.

But Skalak says Allen intends to fund such established scientists» work in «wholly new» areas: Doudna, for example, will explore a new mechanism to edit cellular function by targeting RNA.

Drugs used in targeted gene therapy operate by inhibiting one or more cellular processes.

Wahl was on the tenure track in 2002 as a pathology researcher at Duke University, identifying cellular targets for cancer therapies, when funding dried up for her research and she consequently failed to get tenure.

These technologies are leading to transformative advances in how we interact with and program biology and are being applied to address key challenges in scalable biosynthesis platforms, cellular therapeutics and targeted molecular therapies.

The most common probes, which use fluorescent markers or radioactive labels to pinpoint the virus's location in a tissue sample, sometimes have difficulty distinguishing the target — HIV RNA and DNA — from surrounding cellular components.

«The structure of kinesin - 5 is unexpected, and the implications are big — it allows us to target it, for example in various forms of cancer,» said Jawdat Al - Bassam, assistant professor of molecular and cellular biology at UC Davis, who led the project.

During the early years of my PhD studies, I was very fascinated by the exciting discoveries in the field of signal transduction, in particular how receptor tyrosine kinases are activated to transmit their signals and how protein complexes are formed through defined protein folds (domains) interacting with specific cellular targets.

The role of academic scientists in this process has largely been to explain the genetic / cellular basis of diseases for identifying useful targets and provide new chemical and computational methods to improve the pharmacological profile of potential drugs.

Researchers from the Institut Pasteur, CNRS and Inserm, in collaboration with a team from Switzerland, have discovered a previously unknown mechanism by which L. pneumophila targets mitochondria to modulate mitochondrial dynamics and thereby impairs mitochondrial respiration which in turn leads to a change in the cellular metabolism.

Known as much for its complexity as its vital role in regulating cellular and organismal growth, the mechanistic target of rapamycin complex 1 (mTORC1) pathway has seemingly been acting in mysterious ways.

Direct measurement of such compound target engagement in a cellular or tissue context has traditionally been difficult to establish without the development of specific tool compounds and / or protein modifications with reporter functionalities.

In addition, her lab is evaluating ways to target anti-cancer medications more specifically to the cancer cell by targeting the cellular mechanism of the cancer.

To meet this end, CCIR members take advantage of resources offered by MD Anderson, including the CCSG Shared Resources, Immune Monitoring Core Laboratory and GMP Cell Facility, allowing them to follow the «bench - to - beside» approach to develop and improve cancer immunotherapy in the form of cellular therapy, a vaccine or targeting antibody, either alone or in combination with conventional therapies or newly developed therapies.

Mass spectrometry ‐ based cellular thermal shift assay (MS ‐ CeTSA) analysis of CDK4 / 6 inhibitor palbociclib targets in MCF7 human breast cancer cells identifies protein complexes including the 20S proteasome.

The Cell Surface Signalling Laboratory is interested in identifying new therapeutic targets for both genetic and infectious diseases by using large - scale systematic approaches to discover receptor - ligand interactions that are essential for cellular recognition processes.

Analysis of targeted mutation in DJ - 1 on cellular function in primary astrocytes.

The targets for this suppression are DC, CD4 + Th, CD8 + CTL and NK cells; in effect MSC silence each aspect of the cellular rejection process.

We are interested in topics ranging from how membranes contributed to the origin of cellular life, to identifying membrane - based targets for antibiotic resistance.

This project has the potential to uncover clinically relevant mechanisms of cellular senescence in fibrosing ILDs and identify new therapeutic targets

Diverse cellular functions and therapeutic implications of Poly (ADP - ribose) family members: promising targets in cancer therapy

This family of proteins is responsible for a vast array of cellular communication — including the light - sensing molecules in your retinas, the sugar sensors in your gut, and many of the neurotransmitter receptors that underlie the thoughts and emotions that move through your brain — and these proteins are the targets of the vast majority of pharmaceutical drugs.

The cellular processes that we have identified in this study as being important for the development of stomach cancer provide new targets for therapy that have not been explored before,» Dr. O'Reilly said.

Tenaya is dedicated to addressing heart failure through a multipronged effort that targets the fundamental cellular pathologies present in diseased cardiac muscle and leverages cutting - edge research in cardiac regeneration, induced pluripotent stem cells, and CRISPR technologies.

In other words, modification of chromatin arises due to cellular signaling to particular genome loci and does not appear to be propagated independently of genome targeting.

Establishing the role of cigarette smoke in progression of cancer will not only produce the necessary evidence for implementing smoking cessation interventions but may also help to identify cellular mechanisms for therapeutic targeting.

He has made several important contributions in this area including identifying a new strain of CHIKV virus, identification of host cellular targets of HIV accessory genes, new novel DNA vaccine approaches for HIV, CHIKV, RSV, Dengue, MERS and Zika among others.

With DriverMap, Cellecta offers a novel, comprehensive end - to - end service portfolio for identifying differential gene expression, mapping of clinically actionable mutations in RNA, detecting cellular composition, and profiling immunotherapy targets.

Ultimately, the center's goal will be to control these circuits through therapeutic targeting in a variety of biological systems, including cellular reprogramming, neuroscience, cancer, and infectious disease.

The restriction of cellular growth by p53 has been reported to result in cell cycle arrest or apoptosis [6], and targeting p53 and restoring p53 function to limit tumor growth has been intensively researched for cancer therapy [7].