Established in 1992, ISCT is a global society of clinicians, researchers, regulators, technologists and industry partners with a shared vision to translate
cellular therapy into safe and effective therapies to improve patients» lives worldwide.
Not exact matches
Gilead's deep dive
into cellular therapeutics with the acquisitions of Kite Pharma and Cell Design Labs, along with the subsequent licensing deal with Sangamo Therapeutics to develop off - the - shelf cell
therapies, is another key value creator that's arguably being under - appreciated by the market.
Pediatric physicians and heart surgeons are the first to admit that these basic
cellular findings don't translate
into an immediate
therapy for these newborns.
Meanwhile, cancer genome projects have yielded unprecedented insights
into the
cellular signaling pathways that drive the development and progression of cancer — information that has led to effective
therapies tailored for individual patients.
«Alcohol prevents ability to extinguish fearful memories in mice: Insight
into cellular mechanisms illuminates biological target for PTSD
therapy.»
Ninety percent of children and adults with acute lymphoblastic leukemia (ALL) who had relapsed multiple times or failed to respond to standard
therapies went
into remission after receiving an investigational personalized
cellular therapy, CTL019, developed at the Perelman School of Medicine at the University of Pennsylvania.
Yamanaka said, «We hope that further trials of iPSC - based
therapies, accompanied by basic research focused on gaining more detailed, molecular insights
into the process of
cellular reprogramming itself, will result in unveiling the full potential of iPSCs in the next decade.
Unlike the case of most gene
therapies that are intended to permanently alter their target cells, however, Oisín's senoablative genetic constructs will not be inserted permanently
into the patient's genome: instead, its genetic payload will be expressed temporarily from the main body of the cell, following which the construct will be passively degraded by normal
cellular metabolism.
Everon is a leader in understanding
cellular mechanisms of aging and translating this knowledge
into development of anti-aging
therapies.
The important question now is whether these barriers are high enough to preclude the translation of fundamental hiPSC discoveries
into cellular therapies.
Dr. Jain's nominators note that, in sum, his work has provided ``... unprecedented molecular,
cellular, anatomical and functional insights
into the vascular pathophysiology of tumors, for proposing the seminal hypothesis that antiangiogenic
therapy can «normalize» the aberrant vasculature and microenvironment of tumors and thereby improve both delivery and efficacy of treatment of solid tumors.»
The application of subclonal reconstruction methods is providing key insights
into tumor evolution, identifying subclonal driver mutations, patterns of parallel evolution and differences in mutational signatures between
cellular populations, and characterizing the mechanisms of
therapy resistance, spread, and metastasis.
Cold laser
therapy — also known as low level laser
therapy — is a state - of - the - art technology that delivers light of a very specific wavelength
into tissue to reduce pain and inflammation and to promote healing at the
cellular level.