Sentences with phrase «cellular tissue in»

Chadwick's Viral Landscapes (1989 - 90), made at the height of the Aids epidemic, connect the changes in her body with those of the wave - shattered shoreline, superimposing outsize photographs with magnified images of the artist's cellular tissue in a sweeping panorama of time and tide.

Not exact matches

They are the building blocks of every structure in human skin; vital skin proteins like collagen, elastin, lipids and all cellular tissues are made from amino acids.

Succinic acid, a natural healing oil is a component found in plant and animal tissues and has a very positive effect on cellular metabolism.

For it to be useful, cryopreserved ovarian tissue must thaw in a way that maintains its original cellular structure and function.

These engineers design and build the myriad medical devices and healthcare equipment in such demand these days, as computer - assisted surgery, orthopedic engineering, cellular and tissue engineering, and much else are called on to treat an older, fatter, and less fit population.

«For 2D or 3D cardiac tissue to be functional it needs the same high cellular density and the cells must be in contact to facilitate synchronized beating.»

Other biomedical engineers work in cellular, tissue, and genetic engineering and develop artificial organs and biomaterials.

In GVHD, donor cells trigger an immune response that attacks normal tissues, leading to a chain reaction of cellular and molecular responses that increase morbidity and mortality in these patientIn GVHD, donor cells trigger an immune response that attacks normal tissues, leading to a chain reaction of cellular and molecular responses that increase morbidity and mortality in these patientin these patients.

«To date, there has been no systematic means of assessing the fidelity of cellular engineering — to determine how closely cells made in a petri dish approximate natural tissues in the body,» says George Q. Daley, MD, PhD, Director of the Stem Cell Transplantation Program at Boston Children's and senior investigator on both studies.

Using this approach, researchers can easily generate diseaserelevant isogenic models to determine the impact of correcting or introducing disease - relevant mutations on cellular phenotypes in a tissue - appropriate context.

«Immune system found to control eye tissue renewal in zebrafish: Discovery suggests that strategies to regulate immune system cell reactivity to injury and cell loss might one day unlock and boost human tissue and cellular regeneration.»

The technology was also able to detect cancer in marginal regions between normal and cancer tissues that presented mixed cellular composition.

While changes in insulin secretion are unlikely to play a major role in the acute effects of SD, cellular stress in pancreatic tissue suggests that chronic SD may contribute to the loss or dysfunction of endocrine cells, and that these effects may be exacerbated by normal aging, say the researchers.

Pancreas tissue from acutely sleep - deprived aged animals exhibited a marked increase in CHOP, a protein associated with cell death, suggesting a maladaptive response to cellular stress with age that was amplified by sleep deprivation.

The team examined tissues in mice for cellular stress following acute SD, and they also looked for cellular stress in aging mice.

The investigators suggest that the premature loss of estrogen caused by the oophorectomy may affect a series of aging mechanisms at the cellular and tissue level across the whole body leading to diseases in multiple systems and organs.

«Calcium signaling regulates many important cellular functions, like muscle contraction, neural communication, gene transcription and tissue growth,» said Fenfang Li, a postdoctoral research fellow in Zhong's laboratory and lead author of the study.

«What this gives us is a total view, from the genetic level, to the molecular level, to the cellular or tissue level, to something that a physician would see — a hernia in a newborn.»

Instead, tumors should be considered complex tissues in which the cancer cells communicate with the surrounding cellular microenvironment and evolve traits that promote their own survival.

Gartner's group plans to use the technique to investigate what cellular or structural changes in mammary glands can lead to the breakdown of tissue architecture associated with tumors that metastasize, invading other parts of the body and threatening the life of the patient.

Instead, tumors should be considered as complex tissues in which the cancer cells communicate directly and indirectly with the surrounding cellular microenvironment and evolve traits that promote their own survival.

It thus seems quite likely that this new signaling path also links the performance of the cellular power plants and cell division in human cells,» says Meisinger, who now plans to analyze these mechanisms in tumor tissues.

Imagined applications include engineered immune cells that can sense and respond to cancer markers or cellular biosensors that can easily diagnose infectious disease in patient tissue.

Think of the army of cellular agents, including white blood cells and platelets, that jump into action over a mere paper cut — rebuilding the tissue, warding off infection, and alerting the rest of the body to the wound through the A-delta fibers of the nervous system, which are involved in the transmission of acute pain sensations.

The researchers were able to replicate this finding by comparing the healthy thyroid tissues in GTEx to 500 samples taken from thyroid tumors, compiled by The Cancer Genome Atlas, and giving support to the extensive impact of FOXE1 on cellular state.

Working with mouse, fly and human cells and tissue, Johns Hopkins researchers report new evidence that disruptions in the movement of cellular materials in and out of a cell's control center — the nucleus — appear to be a direct cause of brain cell death in Huntington's disease, an inherited adult neurodegenerative disorder.

A unique feature of this DREADD system not found in other methods is that it is not limited to the control of neurons — activity levels of certain enzymes in almost every tissue type can be controlled to probe mechanisms of basic cellular function.

This signature showed that a cellular communication network called JNK1 was activated to a greater extent in fibroblasts from high density breast tissue.

The most common probes, which use fluorescent markers or radioactive labels to pinpoint the virus's location in a tissue sample, sometimes have difficulty distinguishing the target — HIV RNA and DNA — from surrounding cellular components.

BOND OF LIFE A link between nitrogen and sulfur atoms (bond shown in green) helps hold together protein strands (yellow and white) that create a cellular scaffold essential for tissue and organ formation.

This uncontrolled inflammation is associated with changes in bacteria populations in the gut, which can invade the mucosal tissue after damage to the protective cellular barrier lining the tissue.

Writing in the latest issue of the journal Nature, researchers in the laboratories of Gladstone Senior Investigator Sheng Ding, PhD, and UCSF Associate Professor Holger Willenbring, MD, PhD, reveal a new cellular reprogramming method that transforms human skin cells into liver cells that are virtually indistinguishable from the cells that make up native liver tissue.

The research highlights the importance of investigating different cell types in normal human tissues to understand the cellular origin of cancer and the factors that may contribute to its development.

Traditional hydrogels made up of either synthetic polymers or natural biomolecules often serve as passive scaffolds for molecular or cellular species, which render these materials unable to fully recapitulate the dynamic signaling involved in biological processes, such as cell / tissue development.

But in earlier work Drs. Summer and Romero have shown that when lung tissue is injured — by things like viral infection, particulate inhalation, or other insults — lung cells eventually stop producing lipids in order to conserve energy for other cellular repairs.

Now, a University of Pittsburgh researcher has used the components of the cellular «scaffolding» of a zebrafish to regenerate heart tissues in mammals, specifically mice, as well as exhibiting promising results in human heart cells in vitro.

In tissues such as liver and skeletal muscle, FAO can provide over 75 % of cellular adenosine triphosphate, while in cardiac tissue it can be responsible for up to 90 In tissues such as liver and skeletal muscle, FAO can provide over 75 % of cellular adenosine triphosphate, while in cardiac tissue it can be responsible for up to 90 in cardiac tissue it can be responsible for up to 90 %.

This series addresses the contribution of cellular senescence to cardiovascular, neurodegenerative, and arthritic disorders as well as the senescent phenotypes in various tissues and cell types.

In 1963 Pietro Angeletti and one of us (Levi Montalcini), who were then at the Istituto Superiore di Sanità in Rome, dissected sensory and sympathetic ganglia into their cellular components: neurons, glial cells (which support and nourish the neurons) and fibroblasts (embryonic connective - tissue cellsIn 1963 Pietro Angeletti and one of us (Levi Montalcini), who were then at the Istituto Superiore di Sanità in Rome, dissected sensory and sympathetic ganglia into their cellular components: neurons, glial cells (which support and nourish the neurons) and fibroblasts (embryonic connective - tissue cellsin Rome, dissected sensory and sympathetic ganglia into their cellular components: neurons, glial cells (which support and nourish the neurons) and fibroblasts (embryonic connective - tissue cells).

Previous work by Fredberg and colleagues had documented the importance of collective cellular behavior in asthma, showing that cells comprising epithelial tissues — which line the surfaces of all organs throughout the body — can unjam and flow like a fluid, or jam and freeze like a solid.

Direct measurement of such compound target engagement in a cellular or tissue context has traditionally been difficult to establish without the development of specific tool compounds and / or protein modifications with reporter functionalities.

Finally, the HZI will help develop in vivo imaging technologies to characterize (i) vaccine biodistribution and persistence, and (ii) cellular and molecular changes at the injection site and in draining lymphoid tissues, helping to refine the use of animal models.

For setting cancer in the context of ageing tissue, study of normal adult homeostasis is important — we are studying mutational processes, clonal dynamics and cellular competition in thousands of non-cancerous cells and samples from a range of tissue types, in health and disease.

The overall goal of the research in the lab is to understand organ formation from the cellular to the tissue level.

Although some of the key molecular components involved in the formation of cellular structures and tissue formation are known, we currently lack a bottoms up understanding of how the behavior of these molecules gives rise to the formation of large structures, partly because of the lack of tools for both studying the spatial regulation of soluble proteins and biophysically characterizing the behavior of large structures and tissues.

He studies the molecular mechanisms by which female steroid hormones such as estrogen control development, differentiation, cellular proliferation and survival in hormone - responsive tissues and cancers.

A second line of research is to use skeletal muscle formation in the chick embryo as a model to understand how cells within tissues display complex behaviours while being exposed to an ever - changing cellular environment.

Ideally cellular transcript levels should be measured «in vivo» in unperturbed cells to provide an unbiased characterization of true physiological cellular transcriptomes, and this should in turn be performed individually in each of the millions of cells that constitute a living tissue.

One new way that scientists study this process of cellular development — and a way in which they hope to grow replacement tissue for medical treatments in the future — is by recreating the essential features of human brains, eyes, lungs, and guts in a petri dish.

Histologic sections of tissues exhibiting this type of response have a notable eosinophilic component in the cellular infiltrates.