In the organoids, the scientists found such mechanical instability in two places: the cytoskeleton — the internal skeleton — of the cells in
the center of the organoid contracted, and the nuclei of the cells near the surface expanded.
Not exact matches
If the human
organoid caused such changes, it would raise profound ethical concerns, said bioethicist Josephine Johnston
of The Hastings
Center.
For example, the nuclei in the
centers of the mutant
organoids moved more slowly, and we saw significant differences in gene expression.»
For pluripotent stem cells, that means exposing them to just the right growth factors or inhibitors at just the right times, over about a month, says James Wells
of the
Center for Stem Cell and
Organoid Medicine at Cincinnati Children's Hospital Medical
Center.
Charles Sawyers
of Memorial Sloan Kettering Cancer
Center in New York City is trying to make prostate cancer
organoids, but he says they are finicky.
Around the same time, Yoshiki Sasai
of the RIKEN
Center for Developmental Biology in Kobe, Japan, cultured the first brain
organoids, starting not with adult stem cells but with embryonic stem cells.
Columbia University Irving Medical
Center (CUIMC) and NewYork - Presbyterian researchers have created patient - specific bladder cancer
organoids that mimic many
of the characteristics
of actual tumors.
The directors
of the
organoid course are Hugo de Jonge, Ph.D, professor at Erasmus University Medical Center (Erasmus MC) in Rotterdam, Netherlands, and a visiting professor at the MDI Biological Laboratory, and Robert Vries, Ph.D., managing director at Foundation Hubrecht Organoid Tec
organoid course are Hugo de Jonge, Ph.D, professor at Erasmus University Medical
Center (Erasmus MC) in Rotterdam, Netherlands, and a visiting professor at the MDI Biological Laboratory, and Robert Vries, Ph.D., managing director at Foundation Hubrecht
Organoid Tec
Organoid Technology.
The team used pancreatic
organoid technology developed in the lab
of Professor David Tuveson, Director
of CSHL's Cancer
Center and Director
of Research for the Lustgarten Foundation.
Hugo de Jonge, an associate professor at Erasmus Medical
Center in The Netherlands and director
of the MDI Biological Laboratory's new biomedical innovation course, «Applications
of Organoid Technology,» discusses the potential
of this fascinating new «mini-organ» technology in this exclusive editorial in Regenerative Medicine Network.