Sentences with phrase «central role in cancer»

Dr. Bo Xu and his team at Southern Research are exploring exactly how the building block of life, DNA, plays a central role in cancer - cell formation and how penetrating these -LSB-...]

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As I've said, there have been a number of research papers of late, led in large part by the work of French scientist Laurence Zitvogel, that are building a strong case for a central role for the microbiome in cancer treatment response.

Jerry cautions, though, that other molecular players may play a central role in keeping cancer at bay.

Their findings suggest that miR - 940 plays a central role in the bone - forming ability of prostate cancer.

The researchers discovered a single letter variant located in TP53, a gene known to play a central role in tumor biology and for accumulating so called somatic mutations, during the development of cancer in patients.

Researchers have discovered a gene that plays a central role in black skin cancer, also known as melanoma.

It has a critical role in regulating cell proliferation, so understanding ERK regulation is central to efforts to design new cancer drugs and other disease therapies.

«Inflammation plays a central role in many diseases, cancer, arteriosclerosis, rheumatoid arthritis, infections, in fact, inflammation is a major cause of human misery,» says Inder Verma, professor in the Laboratory of Genetics and lead scientist of both studies.

Scientists from the UNC School of Medicine have developed a new tool for studying a key process in cells called G - protein signaling, which plays a central role in the normal functioning of cells and can go awry to cause severe disease, including cancers.

Dr. Blackburn won the Nobel Prize in Physiology or Medicine in 2009 for discovering the molecular nature of telomeres and for co-discovering the enzyme telomerase; both telomeres and telomerase are thought to play central roles in aging and diseases such as cancer.

In models lacking NLRX1, innate immune cells called macrophages produce higher levels of IL - 6, a signaling molecule that has a central role in colorectal cancer developmenIn models lacking NLRX1, innate immune cells called macrophages produce higher levels of IL - 6, a signaling molecule that has a central role in colorectal cancer developmenin colorectal cancer development.

UT MD Anderson Scientists Discover Secret Life of Chromatin (08/30/2011) A team of researchers directed by Dr. Sharon Dent, director of the Department of Epigenetics and Molecular Carcinogenesis and Center for Cancer Epigenetics, investigate a signaling activity of chromatin that is independent of its central role in gene transcription.

GSK3β, the first neighbour of β - catenin is a central, highly multi-functional protein known as a key protein difficult to inhibit without causing side effects and toxicity.41 In glioblastoma and NSCLC cancer, previous studies found that the decreased level of FRAT1 influences the GSK3β activity to phosphorylate β - catenin and by that, inhibit the WNT pathway.39, 40 The role of FRAT1 in colon cancer is less known but based on its function in other cancer types and its special influencing position in colon cancer signalling, we point out its relevance as a potential target in colon cancer therapy (Fig. 3dIn glioblastoma and NSCLC cancer, previous studies found that the decreased level of FRAT1 influences the GSK3β activity to phosphorylate β - catenin and by that, inhibit the WNT pathway.39, 40 The role of FRAT1 in colon cancer is less known but based on its function in other cancer types and its special influencing position in colon cancer signalling, we point out its relevance as a potential target in colon cancer therapy (Fig. 3din colon cancer is less known but based on its function in other cancer types and its special influencing position in colon cancer signalling, we point out its relevance as a potential target in colon cancer therapy (Fig. 3din other cancer types and its special influencing position in colon cancer signalling, we point out its relevance as a potential target in colon cancer therapy (Fig. 3din colon cancer signalling, we point out its relevance as a potential target in colon cancer therapy (Fig. 3din colon cancer therapy (Fig. 3d).

Similar to the physical and cellular burn of exercise that creates some oxidizing free radicals, the «stress» from cruciferous vegetables stimulates our mitochondria to produce homemade antioxidants to counterbalance the oxidation and protect our vital DNA.28 Even cancer cells have caught on to this central role of our mitochondria — the bastards can amplify their levels of some of these same pathways — further stressing their importance for survival.25 However, our cells still seem to have the upper hand, as multiple studies show that the organosulfur chemicals in many of these anticancer vegetables can severely stress cancer cells, leading to oxidative damage, and ultimately, death.29

Emerging research indicates that the gut microbiome plays a central role in the regulation of estrogen levels within the body and thus influences the risk of developing estrogen - related diseases such as endometriosis, polycystic ovary syndrome, breast cancer, and prostate cancer.

(20) http://www.ncbi.nlm.nih.gov/pubmed/3358913 The dose - effect relationship between «unopposed» oestrogens and endometrial mitotic rate: its central role in explaining and predicting endometrial cancer risk.Key TJ, Pike MC.

It should be stated that titamin B12, Folic acid and Pyridoxine have a central role in cell growth and energy production and have given rise speculation that these vitamins may increase the promotion of carcinogenesis and enhance the growth of cancer cells at high doses.