Cerebellar crowding in the rostral and caudal parts of the CCF was expressed as the percentage of that part of the CCF which was occupied by cerebellum (Caudal Cerebellar CCF Percentage and Rostral Cerebellar CCF Percentage).
Cavalier King Charles Spaniels (CKCS) showed a relationship between
cerebellar crowding and volume in both the rostral CCF (p = 0.0008) and caudal CCF (p = 0.0003) and Labradors (LD) and small breed dogs (SB) did not.
Furthermore, the degree of
cerebellar crowding in the caudal CCF is correlated with increased volume of the cerebellum in CKCS and this is not seen in small breed dogs or Labradors.
In contrast to small breed dogs and Labradors, CKCS exhibit correlation between increased cerebellar volume and
cerebellar crowding within the caudal CCF, suggesting that CCF growth in CKCS is not keeping pace with the growth of the cerebellum.
Our results support hypothesis iii) which states that in CKCS an increase in relative cerebellar volume is correlated with an increase in
cerebellar crowding in the caudal CCF.
We also found in CKCS that
cerebellar crowding in the caudal CCF is more sensitive to changes in relative cerebellar volume than
cerebellar crowding in the rostral CCF, which is consistent with the theory that increased cerebellar volume results in the cerebellum shifting caudally and causes obliteration of dead space in the caudal CCF.
Not exact matches
The malformation is comparable to the Chiari type I malformation described in people and includes a congenital malformation of the occipital bone, resulting in a
crowded caudal fossa and
cerebellar herniation at the foramen magnum.
Crowding of cerebellum is defined as the percentage of the volume of each part of the caudal cranial fossa (CCF) which is occupied by
cerebellar parenchyma (Rostral Cerebellar CCF Percentage and Caudal Cerebellar CCF Pe
cerebellar parenchyma (Rostral
Cerebellar CCF Percentage and Caudal Cerebellar CCF Pe
Cerebellar CCF Percentage and Caudal
Cerebellar CCF Pe
Cerebellar CCF Percentage).
In our study we tested the hypothesis that this
crowding was due to increased
cerebellar volume.
We found that increased
cerebellar volume in the CKCS is correlated with
crowding of the cerebellum in the caudal CCF and this is not seen in Labradors or small breed dogs.
Crowding of cerebellum is defined as the percentage of the volume of each part of the caudal cranial fossa (CCF) which is occupied by
cerebellar parenchyma (panel A: Rostral Cerebellar CCF Percentage, panel B: Caudal Cerebellar CCF Pe
cerebellar parenchyma (panel A: Rostral
Cerebellar CCF Percentage, panel B: Caudal Cerebellar CCF Pe
Cerebellar CCF Percentage, panel B: Caudal
Cerebellar CCF Pe
Cerebellar CCF Percentage).
Our results show that the CKCS has a relatively larger cerebellum than small breed dogs and Labradors and provide evidence that increased
cerebellar volume in CKCS is associated with
crowding of cerebellum in the caudal part of the CCF.