Sentences with phrase «cerebellar volume»

vs. Cerebellar Brain Percentage (r = 0.2801, p = 0.1158) in SM - negative CKCS revealed no statistically significant relationships between relative cerebellar volume and age.

Unlike humans, we found that CKCS do not appear to have age - related atrophy as there was no correlation between relative cerebellar volume and age.

Our results show that the CKCS has a relatively larger cerebellum than small breed dogs and Labradors and provide evidence that increased cerebellar volume in CKCS is associated with crowding of cerebellum in the caudal part of the CCF.

Relative cerebellar volume was defined as the volume of the cerebellum divided by the total volume of brain parenchyma.

Cerebellar volume is potentially a key factor in determining the degree of obstruction and interference in normal CSF flow through the foramen magnum, which disposes dogs to the subsequent development of SM.

We nevertheless conducted an analysis of cerebellar volume and age in SM - negative CKCS to see if this was a potential source of bias.

CKCS had a relatively larger Cerebellar volume (and a similar brainstem volume) when compared to small breed dogs and Labradors, supporting hypothesis i)(that CKCS have increased cerebellar volume compared to other breeds of dog).

Owing to size and conformational differences between dogs, raw volume was considered to be an inappropriate measurement and cerebellar volume was therefore evaluated by using nearby structures, against which it was standardised.

Our findings show that the CKCS has a relatively larger cerebellum than small breed dogs and Labradors and there is an association between increased cerebellar volume and SM in CKCS.

Moreover, Cavalier King Charles spaniels have relatively increased cerebellar volume compared to other breeds and overcrowding of the cerebellum in the caudal part of the caudal cranial fossa is correlated with the development of syringomyelia [6]--[9].

In this study we found that CKCS under the age of 2 with SM (the CM / SM group) have an increased cerebellar volume when compared to CKCS over the age of 5 without SM.

In contrast to small breed dogs and Labradors, CKCS exhibit correlation between increased cerebellar volume and cerebellar crowding within the caudal CCF, suggesting that CCF growth in CKCS is not keeping pace with the growth of the cerebellum.

Citation: Shaw TA, McGonnell IM, Driver CJ, Rusbridge C, Volk HA (2012) Increase in Cerebellar Volume in Cavalier King Charles Spaniels with Chiari - like Malformation and Its Role in the Development of Syringomyelia.

We found that increased cerebellar volume in the CKCS is correlated with crowding of the cerebellum in the caudal CCF and this is not seen in Labradors or small breed dogs.

In our study we tested the hypothesis that this crowding was due to increased cerebellar volume.

Previous volumetric studies in CKCS have shown that there is an association between SM and CCF parenchyma volume [19], [26], but this is the first time that Cerebellar volume has been linked to SM.

In order to assess the clinical significance of cerebellar volume and CCF volume as prognostic indicators, further cohort and longitudinal studies are needed.

It has been found that pre-natal posterior cranial fossa development in humans is independent of cerebellar volume but closely parallels the development of the supratentorial bony compartment [43].

The relationship between cerebellar overcrowding and relative cerebellar volume was tested with a Pearson r correlation of Caudal Cerebellar CCF Percentage and Cerebellar Brain Percentage: The CKCS group demonstrated a positive correlation (r = 0.5204 [p = 0.0003]-RRB-, whilst the SB (r = 0.1277 [p = 0.4449]-RRB- and LD (r = 0.3016 [p = 0.1342]-RRB- group did not.

Our results support hypothesis iii) which states that in CKCS an increase in relative cerebellar volume is correlated with an increase in cerebellar crowding in the caudal CCF.

We also found in CKCS that cerebellar crowding in the caudal CCF is more sensitive to changes in relative cerebellar volume than cerebellar crowding in the rostral CCF, which is consistent with the theory that increased cerebellar volume results in the cerebellum shifting caudally and causes obliteration of dead space in the caudal CCF.

Our findings support the hypotheses that CKCS have increased cerebellar volume compared to other breeds and that increased cerebellar volume in CKCS is linked to the development of SM.

«The difference in ape cerebellar volume, relative to a scaled monkey brain, is equal to 16 billion extra neurons,» says Barton.

While the relationship between age and brain atrophy in humans is well documented and could potentially bias a comparison between different age groups, there is no evidence that this is the case in dogs (a recent study has shown that Labradors in the age groups 1 — 5, 5 — 10 and 10 + have similar cerebellar volumes)[22] or even chimpanzees [25].

Not exact matches

Cerebellar blood volume in bipolar patients correlates with medication.

Crowding of cerebellum is defined as the percentage of the volume of each part of the caudal cranial fossa (CCF) which is occupied by cerebellar parenchyma (Rostral Cerebellar CCF Percentage and Caudal Cerebellar CCF Pecerebellar parenchyma (Rostral Cerebellar CCF Percentage and Caudal Cerebellar CCF PeCerebellar CCF Percentage and Caudal Cerebellar CCF PeCerebellar CCF Percentage).

These parameters are accepted standards in canine brain volume measurement as they have been used in a study of cerebellar atrophy [22] and CCF parenchyma volume [18], [19].

Crowding of cerebellum is defined as the percentage of the volume of each part of the caudal cranial fossa (CCF) which is occupied by cerebellar parenchyma (panel A: Rostral Cerebellar CCF Percentage, panel B: Caudal Cerebellar CCF Pecerebellar parenchyma (panel A: Rostral Cerebellar CCF Percentage, panel B: Caudal Cerebellar CCF PeCerebellar CCF Percentage, panel B: Caudal Cerebellar CCF PeCerebellar CCF Percentage).

Furthermore, the degree of cerebellar crowding in the caudal CCF is correlated with increased volume of the cerebellum in CKCS and this is not seen in small breed dogs or Labradors.

The volume of the cerebellum is expressed as a percentage of the total brain volume (Cerebellar Brain Percentage).

Cavalier King Charles Spaniels (CKCS) showed a relationship between cerebellar crowding and volume in both the rostral CCF (p = 0.0008) and caudal CCF (p = 0.0003) and Labradors (LD) and small breed dogs (SB) did not.

The volume of the cerebellum is expressed as a percentage of the caudal cranial fossa volume (Panels A and B: Cerebellar CCF Percentage) and a percentage of the total brain volume (Panels C and D: Cerebellar Brain Percentage).

Socioeconomic status and the cerebellar grey matter volume.