Global versus tract - specific components
of cerebral white matter integrity: relation to adult age and perceptual - motor speed
Deep sequencing
of cerebral white matter - derived RNA from the HIV (n = 4) and ODC (n = 4) patients and SURG (n = 2) groups revealed bacterially - encoded 16 s RNA sequences in all brain specimens with α - proteobacteria representing over 70 % of bacterial sequences while the other 30 % of bacterial classes varied widely.
The primary regions of difference are
the cerebral white matter (yellow) and the cerebellum (red).
Compared to the brains of people without bipolar disorder, the researchers found that the MRI signal was elevated in
the cerebral white matter and the cerebellar region of patients affected by bipolar disorder.
T1ρ values were found to be elevated in
the cerebral white matter and cerebellum in the bipolar group.
These findings are consistent with metabolic or microstructural abnormalities in bipolar disorder and draw attention to roles of
the cerebral white matter and cerebellum.
There is a uniform, diffuse sclerosis of
the cerebral white matter, as well as demyelination.