So what we think is that probably in many cells in this section, all cells, the
chromatin is encountered in a specific
state, and in order to render the cell is permissive to reprogramming, you have to overcome these
certain epigenetic modifications that block, for example, the binding of Ascl1 to its target chains, or the binding of other transcription factors to its target chains, then this way interfere with the possibility of reprogramming.