Not exact matches
These and other observations suggest that many different
classes of regulatory substances achieve
certain of their biological effects by altering the phosphorylation
of specific
proteins.
To find out, she and her MIT colleagues targeted a
class of proteins called TRPV1 channels, which are found in neurons that respond to heat and
certain chemicals in food.
Researchers at UT Southwestern Medical Center have identified a second role for a
class of RNA - binding
proteins, revealing new insights about neurological diseases and conditions associated with this
protein such as autism, epilepsy, and
certain types
of cancer.
Juan Bonifacino's lab at the National Institute
of Child Health and Human Development, for one, had discovered the role a
certain protein plays as asymptomatic infection progresses to AIDS but testing
of a new
class of potential HIV medications had to be stopped due to the shutdown.
An entire
class of proteins called transcription factors, which regulate the activity
of certain genes by interacting with specific sequences
of DNA, has largely been ignored by the pharmaceutical industry because it's difficult to design and screen drugs against them.
A
class of therapeutic drugs known as
protein kinase inhibitors has in the past decade become a powerful weapon in the fight against various life - threatening diseases, including
certain types
of leukemia, lung cancer, kidney cancer and squamous cell cancer
of the head and neck.
He noticed that a
certain class of mutations in the heme pocket caused the
proteins to become extraordinarily stable even though the mutations damaged their ability to bind heme and oxygen.
He was a principal investigator
of an ENCODE grant to devise strategies to map the binding
of certain proteins to the human genome and to develop novel experimental approaches to examine specific
classes of regulatory elements.