How do genetic mutations in selected genes lead to elective degeneration in
certain types of neurons in HD, PD, and ALS?
Drugs that target neuregulin 3 could help restore glutamate levels in
certain types of neurons — a novel approach to schizophrenia treatment.
Researchers have begun using genetically encoded sensors to monitor the behavior of individual neurons, and they've been using brief pulses of light to trigger
certain types of neurons to activate.
The data would be used to better predict human response to countermeasures, viruses or pharmaceutical drugs, and could help scientists determine if
certain types of neurons are more susceptible to exposure.
«If you had a hunch that
a certain type of neuron might be important for a particular behavior,» he says, «you could use this technique to see if that's the case — to find out whether activating those neurons elicits the behavior artificially.»
Neurona's founders have discovered that
certain types of neuron transplants can rebalance nervous system activity, repair neural circuits, and rescue multiple animal models of disease.
Not exact matches
But as people get older,
certain neurons die and there is reduced capacity, so these
types of drugs may help.»
A unique feature
of this DREADD system not found in other methods is that it is not limited to the control
of neurons — activity levels
of certain enzymes in almost every tissue
type can be controlled to probe mechanisms
of basic cellular function.
While retroviruses generally only infect dividing cells (because their access to the host genome is thought to rely on the breakdown
of the nuclear envelope that occurs in mitosis [Roe et al., 1993]-RRB-, lentiviruses are a genus
of the retroviral family that can infect non-dividing cells (possibly through the use
of nuclear localization signals by the viral components [Bukrinsky et al., 1992]-RRB-, and thus, offer an advantage when transducing
certain cell
types that exhibit limited cell division (e.g.,
neurons).
One 2015 study reported that brains
of super agers are thicker in
certain areas than normal brains, and also have fewer tangles (a
type of protein associated with Alzheimer's disease), and a large supply
of neurons linked to social intelligence.