Sentences with phrase «change cycles which»

Not exact matches

These fast companies will complete several cycles — learning and improving — while slower firms gear up to complete one innovation cycle, which will result in products and services that solved problems that have already been solved, or have morphed and changed.

As a crime deterrent, Grace and Ubelhart decided to change their business — instead of harvesting the pot plants» buds, they started to sell clones, which have no buds until going through the three - month harvest cycle.

«The part of the brain which regulates the sleep - wake cycle — the Suprachiasmatic Nucleus — changes in puberty.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

These risks include, in no particular order, the following: the trends toward more high - definition, on - demand and anytime, anywhere video will not continue to develop at its current pace or will expire; the possibility that our products will not generate sales that are commensurate with our expectations or that our cost of revenue or operating expenses may exceed our expectations; the mix of products and services sold in various geographies and the effect it has on gross margins; delays or decreases in capital spending in the cable, satellite, telco, broadcast and media industries; customer concentration and consolidation; the impact of general economic conditions on our sales and operations; our ability to develop new and enhanced products in a timely manner and market acceptance of our new or existing products; losses of one or more key customers; risks associated with our international operations; exchange rate fluctuations of the currencies in which we conduct business; risks associated with our CableOS ™ and VOS ™ product solutions; dependence on market acceptance of various types of broadband services, on the adoption of new broadband technologies and on broadband industry trends; inventory management; the lack of timely availability of parts or raw materials necessary to produce our products; the impact of increases in the prices of raw materials and oil; the effect of competition, on both revenue and gross margins; difficulties associated with rapid technological changes in our markets; risks associated with unpredictable sales cycles; our dependence on contract manufacturers and sole or limited source suppliers; and the effect on our business of natural disasters.

Factors that could cause or contribute to actual results differing from our forward - looking statements include risks relating to: failure of DBRS to rate the Notes at the anticipated ratings levels, which is a closing condition, or at all; changes in the financial markets, including changes in credit markets, interest rates, securitization markets generally and our proposed securitization in particular; the willingness of investors to buy the Notes; adverse developments regarding OnDeck, its business or the online or broader marketplace lending industry generally, any of which could impact what credit ratings, if any, are issued with respect to the Notes; the extended settlement cycle for the scheduled closing on April 17, 2018, which may exacerbate the foregoing risks; and other risks, including those described in our Annual Report on Form 10 - K for the year ended December 31, 2017 and in other documents that we file with the Securities and Exchange Commission from time to time which are or will be available on the Commission's website at www.sec.gov.

The second is StashAway's asset allocation framework that adjusts portfolio compositions as macroeconomic and market cycles change, which an individual investor would have difficulty in building such a sophisticated framework.

The economic cycle is measured by the change in gross domestic product (GDP), which is the dollar value of all goods and services within an economy during a stated time period (usually one year or one quarter).

In all this, we make allowance as best we can for the state of the business cycle, and for structural changes which may be affecting the course of these variables.

However, total factor productivity, which allows for changes in both labour and capital inputs into the production process, and is therefore a better measure of efficiency, is growing faster in the current recovery than in the corresponding phases of either of the two previous cycles (Box 2).

Our analytical team has spent almost its entire collective career specializing in change and in industrial distress, which means we have traded well over a hundred different cycles globally, in many industries.

Except for Christianity, which made the momentous change, most major religious traditions have adopted the lunar calendar, even though it conflicts with the agricultural cycle and its solar system.

A combination of climate change (which has significantly shortened the cycles of drought), massive migration to the cities and market pressures to grow cash crops that require huge amounts of water have depleted India's already taxed water supply for rural areas.

The answer will be divided into three categories: (1) AA's effectiveness in breaking the addictive cycle and producing initial sobriety; (2) its effectiveness in producing long - term sobriety; (3) the extent to which the approach is successful in changing underlying personality - structure, rather than simply controlling symptoms.

In the past 25 years they have undertaken endless self - diagnoses which prompted cycles of curriculum change, the development of unwieldy student - faculty - staff bureaucracies and modes of governance, and all sorts of societal field experimentation.

The mandate - generation cycle through which mandates are adopted, funded and implemented, and then considered for continuation, change or elimination, should be re-examined.

The changes which the patient was experiencing, with much travail, are nonetheless precisely those sorts of changes predictable throughout the human life - cycle, about which the fundamental task is to maintain an affirmation of the natural order, with all its vicissitudes.

This balance is a part of the biological clock also known as the circadian cycle, which helps maintain a sleep and wake pattern in synch with body hormonal levels and all associated changes.

Park District director Jerry Handlon said the agency will immediately post no - cycling signs at the natural area's three entrances informing residents of the ordinance change, which formally will take effect Oct. 21.

The Board of Elections said you can change your party affiliation at any time, but it won't go into effect until the next election cycle, which some groups called unfair.

By contrast, Europeans pay a «VAT» - a value added tax - a more complicated scheme by which each time a product changes hands in the business development cycle, a portion of the added value is taxed and used for funding.

Shah said the $ 1.5 million budgeted for the digital program, which could change later in the cycle, is similar to what the group spent in 2014.

This is notable for a number of reasons, not the least of which is the fact that Katko's district, NY - 24, is fairly closely divided and has changed hands between the major parties over the past several election cycles, which means whoever the incumbent is needs NOT to hew too closely to the party leadership and orthodoxy.

But the succession is complicated by the changing demographics of the district, which forced Rangel and his allies to fight bare - knuckled campaigns against Espaillat in the last two election cycles.

«We've discovered that most trees have regular periodic changes in shape, synchronised across the whole plant and shorter than a day - night cycle, which imply periodic changes in water pressure,» says András Zlinszky...

Which is why aerodynamics professor Bert Blocken is advising the international cycling union UCI to change the rules and increase the minimum gap between riders and their team cars.

These mice micro-transmitters collected sleep, muscle activity, and body temperature data, which revealed that the smaller mice experienced progressive changes in sleep patterns, with all phases of the sleep - wake cycle being affected.

According to Klump, not only did rates of emotional eating change across the menstrual cycle, but the degree to which genes influenced eating patterns changed as well.

«As powerful as the cycle is, it is also surprisingly susceptible to environmental changes — and humankind is imposing massive perturbations on Amazonia by both cutting down the trees and heating up the air with greenhouse gases, which reduces large - scale moisture transport and precipitation, and end up affecting even the untouched patches of the forests.»

A new El Niño cycle — warmer surface waters — began last summer, which may mean that stratospheric water levels could change again.

But climate change has brought milder winters, warmer sea temperatures and bigger storms, which create a vicious cycle that promises less sea ice and more wind and open water to generate ice - crushing waves.

In addition to the office space, the lab currently contains a single studio apartment, which the researchers will use to learn how to design living spaces that improve sleep quantity and quality in night - shift workers, and whether changes in these workers» circadian cycles influence their microbiota.

«It's the engine that drives the carbon cycle for the whole world, which makes it important when we discuss climate changes.

Researchers in Hawaii found that guppies released in the 1920s drove down native fish populations, perhaps by competing with them for food and living space, and had likely changed the cycle of nutrients in water: Guppy - rich areas showed increased levels of dissolved nitrogen — from ammonium in fish urine and gill excretions — which, in turn, stimulated algae growth.

«We have added another piece of information showing that the timescales on which humans have changed the composition of the atmosphere are extremely short compared to the natural time cycles of the climate system,» says Thomas Stocker of the University of Bern in Switzerland, who led the research.

«And what we found was that we got the right kind of temperature change and we got a dampened seasonal cycle, both of which are things we think we see in the Pliocene.»

The change is driven by differently timed fruiting cycles between apple trees, which some Rhagoletis prefer, and the North American hawthorn, the native fruit where Rhagoletis have traditionally laid their eggs.

And he points out that using layer thickness to measure Milankovitch cycles requires a risky assumption: that the rate of sediment accumulation, which built these layers, did not change much over 32 million years.

Dams may also change the hydrological cycle in Amazonia, which affects precipitation in the Andes.

The U.S. Global Change Research Program, which coordinates the National Climate Assessment report process, also released draft versions of two other reports for public comment: the Second State of the Carbon Cycle Report and the Fourth National Climate Assessment.

The cycle between an elliptical and circular orbit and a change in the tilt of Earth's axis combined to create periods in which our planet did not tilt very much as it revolved around the sun, thereby eliminating seasons and resulting in less climatic variability.

SEA CHANGE A rethink of earlier studies suggests trouble ahead for a major player in ocean nutrient cycles, the nitrogen - fixing Trichodesmium microbes, which can grow in abundance as seen is this image (pale streaks).

One researcher has looked for clues to solar weather in the meridional flow, which moves from the solar equator toward the poles, and which seems to change speed during the shifting solar cycle.

Repeated cooling cycles gave rise to stresses in the material (see image below), which caused the superconductivity to change its properties.

De Boer's position as executive secretary of the U.N. Framework Convention on Climate Change requires him to use three passports, two of which are constantly in cycle as he gets new visas.

The field study examined a change in the so - called restart provision, which allows drivers to start a new duty cycle after going off duty for at least 34 hours.

The 20,000 - year cycle is driven by changes in the Earth's orbit around the sun, which affects the amount of sunlight received during any particular season.

Climate change and natural climate cycles contribute to the expansion of the Sahara desert, which has grown by about 10 percent since 1920.

They also looked at changes in Martian gravity — which is about one - third that of Earth's gravity — over 11 years (the same as the sun's cycle of activity).

The cycle appears to be a response to changes in the Earth's orbit and tilt, which affect the amount of summer sunlight reaching the northern hemisphere.