Sentences with phrase «change during disease»

The new method, published today in the journal Nature Biotechnology, has implications for better understanding how different groups of cells change during disease progression, in response to drug treatment, or across evolution.

The vectors are customizable and could potentially be used as part of a gene therapy to treat neurodegenerative disorders that affect the entire central nervous system, such as Huntington's disease, or to help map or modulate neuronal circuits and understand how they change during disease.

Not exact matches

Sometimes I feel like there are so many discoveries of diseases, genetic changes or personality quirks that «begin in the womb» that it can be difficult to not feel responsible and guilty during the pregnancy, even when some of these things are out of our control.

This is important, he added, because this technique is increasingly used for classifying diseases and their subtypes, understanding gene expression changes during development and tracking the progression of cancer.

As such, it can help researchers observe changes in synapses during brain development and disease.

Humans are considered uniquely susceptible to Alzheimer's disease, potentially due to genetic differences, changes in brain structure and function during evolution, and an increased lifespan.

Perhaps in the not - so - distant future, children at high risk for coronary artery disease will be identified and treated to prevent changes in their vascular walls during adulthood.»

Professor Sinclair said: «It is well established that prior to conception and in the early stages of pregnancy during natural or assisted reproduction subtle chemical changes can affect the human genome leading to development and late - onset chronic diseases.

The new test allowed them to observe how interactions between synapses and astrocytes change over time, as well as during various diseases, in mouse models.

The study is one of the first to characterize the timing of exposure to such stress and the emergence of the physiologic changes leading to cardio - metabolic disease and to document these relationships during this critical developmental period.

Based on a detailed statistical analysis of multiple datasets, the Flint Area Community Health and Environment Partnership (FACHEP) research team found that the majority of Legionnaires» disease cases that occurred during the 2014 - 15 outbreak in Genesee County, Michigan, can be attributed to the change in of the City of Flint's drinking water supply to the Flint River.

By studying the skeletons of farmers, peasants, monks, and nobles, paleopathologists hope to find out what diseases killed people from medieval times until the present — and how their overall health fluctuated during famine, war, climate change, and other challenges.

Many of these devices resemble sleeker, more efficient models of instrumentation used by research labs to record brain activity during sleep, physiological changes during stress, migraine triggers, activity levels and even early symptoms of debilitating neurological diseases.

LifeTime proposes to go far beyond providing static tissue maps and to track, understand and predict how the molecular make - up of cells changes during human diseases and ultimately intervene.

Despite considerable interest, we still have a lot to learn about BC salmon — factors that determine juvenile survival during migration, susceptibility to disease, as well as how the six salmon species will respond to climate change stressors.

«Over the past ten years, several research groups, including our own, have shown the importance of certain immune cell subsets in preventing or exacerbating heart disease in mice, but we are just beginning to understand how the metabolism and function of these immune cells change during cardiovascular disease progression in humans,» says Hedrick.

For example, using a transgenic marmoset model of Alzheimer's disease, clinicians and basic researchers are working together to identify the changes in the brain's circuitry during mild cognitive impairment and very early stages of Alzheimer's.

Many things that happen during a person's life can change the growth of the brain and a person's chance of developing a disease, explains Jay Giedd.

Our research is focused on understanding how the functions of immune cells, such as monocytes and T lymphocytes, change during the progression of cardiovascular disease and cancer.

«The results suggest that such «master» regulatory factors could activate regions of the genome that are normally inactive, leading to the formation of organs during development, or the initiation of pathological changes in cells that lead to diseases such as cancer,» Taipale said.

Determination of transporter distributions and densities around select synapses in normal adult brains and how these parameters change during development, ageing, drug use and disease

This means that by studying the effect of genetic changes during the domestication of dogs we can also learn about our own species» adaptations to the environment and related diseases.

While many contend that the earliest cognitive deficits are caused by damage to the striatum — a structure deep in the brain known to be severely affected in HD — recent evidence suggests that this claim may paint an incomplete picture of the widespread changes occurring in the brains of HD patients during the very early stages of the disease.

The aim of the study was to investigate the cognitive significance of the changes in default mode network (DMN) during the process of Alzheimer's disease (AD) and the genetic basis that drives the alteration.

The study, published in Molecular & Cellular Proteomics, provides the vascular disease research community with a valuable resource of time - and compartment - resolved proteomic changes during atherogenesis.

Our lab uses both cardiomyoctes derived from human stem cells (iPS cell - derived cardiomyocytes) and mouse models harboring the human mutation to study which exact changes occur during the onset and development of the disease.

The FLI investigates the molecular causes for these aging - associated changes with the goal to uncover new approaches for therapies aiming to preserve the functioning of the body's own stem cells and organs thereby reducing the risk of diseases and cancer during aging.

But we have only a few of the answers, and this is compounded by the ability of cancer to change during treatment, in most cases, making the disease resistant to the targeted therapeutic.

The latest findings, however, leave open the question of what role, if any, estrogen is playing in the constellation of changing occurring during menopause and how that could affect risk factors for heart disease.

A study with older adults at high risk for cardiovascular disease found that vitamin K intake reduced the risk of developing type II diabetes by 17 % for every 100 micrograms of vitamin K consumed per day.3 Moreover, subjects who increased their intake of vitamin K1 during the follow - up has a 51 % reduced risk of diabetes compared to those who decreased or did not change their intake.3 However, supplementation of vitamin K2 appears to be even stronger and more effective, reducing the risk of type II diabetes by 7 % for each 10 - microgram increase in vitamin K2 intake.4

There is a dramatic increase of cortical surface area during late fetal development as a result of cortical folding, while there is a dynamic change of cortical thickness during the entire life span as a result of development and disease.

Speaking about physiological changes of reducing gluten: The elite Division 1 athlete Litholink test slide shown above is N = 1 biological proof (thank you #Litholink) of dramatic improved kidney function moving onto fermented gluten foods during Division 1 elite performance demands, for mild chronic kidney disease impairment.

Dr. Gernez, most famous in France for world - changing work on preventing degenerative diseases, recommended to blow of a minute amount of pollen on newborns (anytime during their immunotolerance period) along with minute amounts of vaccuum cleaner dust collected in late summer («yuk» you may say, I know!)

«Low - Calorie Diet Slows Aging in Mice in Study,» claimed a recent headline.17 According to the article, «Putting elderly mice on a very low - calorie diet for as little as four weeks reversed many of the changes in the activity of various genes that had occurred during normal aging...» The resesearchers were not looking at actual signs of disease, nor were they measuring lifespan, but instead focused on the analysis of 11,000 different genes using a method called microarray technology in which Spindler has large financial holdings.

In the context of treatment, dietary changes are either complementary or central to the course of treatment for a disease which is generally chosen during a patient - doctor interaction.

And, as if the bodily changes that take place during perimenopause weren't uncomfortable enough, they can also increase the risk of a number of more serious concerns: depression or other psychological disorders, severe headaches, bone loss, cardiovascular disease, and metabolic syndrome.

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We stopped updating diet at the beginning of the time interval during which individuals developed cancer (except nonmelanoma skin cancer), cardiovascular diseases, or gestational diabetes because changes in diet after development of these conditions may confound the relationship between diet and diabetes (21).

During times of stress, disease, use of antibiotics, dietary changes or other causes, these bacteria can change leading to an unhealthy or depleted microflora.

Echocardiography is useful in determining a definitive diagnosis of underlying structural disease as it provides a quantitative evaluation of heart chamber size, wall thickness, and the dynamic changes that occur during the cardiac cycle.1

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Once the disease is treated and pain is managed or eliminated, these patients exhibit many positive behavioral changes, as described by many owners during recheck appointments.

Many cats, especially those in the early stages of the disease, may only have changes in the cardiac muscle that are detected during ultrasound examination of the heart.

As the disease progresses, problems with muscle coordination during walking with occasional tripping and change of posture may occur.

Changes in kidney, liver and pancreatic function, arthritis, cataracts, heart disease and high blood pressure are more common in older pets and can be detected during regular check ups and lab work.

This doesn't usually cause intestinal disease, but this is the one that they warn pregnant women about in regards to changing litterboxes during pregnancy.

Lack of previous evidence may be due to the fact that during the last years the ranges of certain vector - borne diseases such as dirofilariasis are extending due to ecological and climatic changes (Irwin, 2002).

During a routine physical we are evaluating body condition, looking for eye or ear problems, dental disease, abnormal heart or lung sounds, changes in abdominal organs or belly pain, musculoskeletal and neurologic conditions, urogenital disease, skin and haircoat conditions and lymphatic disease.

It is dangerous for cats to lose weight too quickly because this predisposes them to the development of hepatic lipidosis, a potentially fatal liver disease whereby fat is deposited within the liver as a result of a change in metabolism during fasting.

during periods of high seasonality and vice-versa during periods of low seasonality — primarily I suppose due to food mix changes, temperatures and disease carrying insects.