Sentences with phrase «change effects over time»

I also hope that this research can be a model for future studies that continue to investigate climate change effects over time and space using the fossil record.

Not exact matches

Important factors that could cause actual results to differ materially from those reflected in such forward - looking statements and that should be considered in evaluating our outlook include, but are not limited to, the following: 1) our ability to continue to grow our business and execute our growth strategy, including the timing, execution, and profitability of new and maturing programs; 2) our ability to perform our obligations under our new and maturing commercial, business aircraft, and military development programs, and the related recurring production; 3) our ability to accurately estimate and manage performance, cost, and revenue under our contracts, including our ability to achieve certain cost reductions with respect to the B787 program; 4) margin pressures and the potential for additional forward losses on new and maturing programs; 5) our ability to accommodate, and the cost of accommodating, announced increases in the build rates of certain aircraft; 6) the effect on aircraft demand and build rates of changing customer preferences for business aircraft, including the effect of global economic conditions on the business aircraft market and expanding conflicts or political unrest in the Middle East or Asia; 7) customer cancellations or deferrals as a result of global economic uncertainty or otherwise; 8) the effect of economic conditions in the industries and markets in which we operate in the U.S. and globally and any changes therein, including fluctuations in foreign currency exchange rates; 9) the success and timely execution of key milestones such as the receipt of necessary regulatory approvals, including our ability to obtain in a timely fashion any required regulatory or other third party approvals for the consummation of our announced acquisition of Asco, and customer adherence to their announced schedules; 10) our ability to successfully negotiate, or re-negotiate, future pricing under our supply agreements with Boeing and our other customers; 11) our ability to enter into profitable supply arrangements with additional customers; 12) the ability of all parties to satisfy their performance requirements under existing supply contracts with our two major customers, Boeing and Airbus, and other customers, and the risk of nonpayment by such customers; 13) any adverse impact on Boeing's and Airbus» production of aircraft resulting from cancellations, deferrals, or reduced orders by their customers or from labor disputes, domestic or international hostilities, or acts of terrorism; 14) any adverse impact on the demand for air travel or our operations from the outbreak of diseases or epidemic or pandemic outbreaks; 15) our ability to avoid or recover from cyber-based or other security attacks, information technology failures, or other disruptions; 16) returns on pension plan assets and the impact of future discount rate changes on pension obligations; 17) our ability to borrow additional funds or refinance debt, including our ability to obtain the debt to finance the purchase price for our announced acquisition of Asco on favorable terms or at all; 18) competition from commercial aerospace original equipment manufacturers and other aerostructures suppliers; 19) the effect of governmental laws, such as U.S. export control laws and U.S. and foreign anti-bribery laws such as the Foreign Corrupt Practices Act and the United Kingdom Bribery Act, and environmental laws and agency regulations, both in the U.S. and abroad; 20) the effect of changes in tax law, such as the effect of The Tax Cuts and Jobs Act (the «TCJA») that was enacted on December 22, 2017, and changes to the interpretations of or guidance related thereto, and the Company's ability to accurately calculate and estimate the effect of such changes; 21) any reduction in our credit ratings; 22) our dependence on our suppliers, as well as the cost and availability of raw materials and purchased components; 23) our ability to recruit and retain a critical mass of highly - skilled employees and our relationships with the unions representing many of our employees; 24) spending by the U.S. and other governments on defense; 25) the possibility that our cash flows and our credit facility may not be adequate for our additional capital needs or for payment of interest on, and principal of, our indebtedness; 26) our exposure under our revolving credit facility to higher interest payments should interest rates increase substantially; 27) the effectiveness of any interest rate hedging programs; 28) the effectiveness of our internal control over financial reporting; 29) the outcome or impact of ongoing or future litigation, claims, and regulatory actions; 30) exposure to potential product liability and warranty claims; 31) our ability to effectively assess, manage and integrate acquisitions that we pursue, including our ability to successfully integrate the Asco business and generate synergies and other cost savings; 32) our ability to consummate our announced acquisition of Asco in a timely matter while avoiding any unexpected costs, charges, expenses, adverse changes to business relationships and other business disruptions for ourselves and Asco as a result of the acquisition; 33) our ability to continue selling certain receivables through our supplier financing program; 34) the risks of doing business internationally, including fluctuations in foreign current exchange rates, impositions of tariffs or embargoes, compliance with foreign laws, and domestic and foreign government policies; and 35) our ability to complete the proposed accelerated stock repurchase plan, among other things.

Apple improved the original portrait mode a lot (which didn't change lighting effects) so I expect this will only improve over time.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

Since a larger share of deposit rates are fixed than are loan rates, this will overstate the effect on cash flows over longer time horizons, though the extent of this bias has not necessarily changed over time in an obvious way.

Such risks and uncertainties include, but are not limited to: our ability to achieve our financial, strategic and operational plans or initiatives; our ability to predict and manage medical costs and price effectively and develop and maintain good relationships with physicians, hospitals and other health care providers; the impact of modifications to our operations and processes; our ability to identify potential strategic acquisitions or transactions and realize the expected benefits of such transactions, including with respect to the Merger; the substantial level of government regulation over our business and the potential effects of new laws or regulations or changes in existing laws or regulations; the outcome of litigation, regulatory audits, investigations, actions and / or guaranty fund assessments; uncertainties surrounding participation in government - sponsored programs such as Medicare; the effectiveness and security of our information technology and other business systems; unfavorable industry, economic or political conditions, including foreign currency movements; acts of war, terrorism, natural disasters or pandemics; our ability to obtain shareholder or regulatory approvals required for the Merger or the requirement to accept conditions that could reduce the anticipated benefits of the Merger as a condition to obtaining regulatory approvals; a longer time than anticipated to consummate the proposed Merger; problems regarding the successful integration of the businesses of Express Scripts and Cigna; unexpected costs regarding the proposed Merger; diversion of management's attention from ongoing business operations and opportunities during the pendency of the Merger; potential litigation associated with the proposed Merger; the ability to retain key personnel; the availability of financing, including relating to the proposed Merger; effects on the businesses as a result of uncertainty surrounding the proposed Merger; as well as more specific risks and uncertainties discussed in our most recent report on Form 10 - K and subsequent reports on Forms 10 - Q and 8 - K available on the Investor Relations section of www.cigna.com as well as on Express Scripts» most recent report on Form 10 - K and subsequent reports on Forms 10 - Q and 8 - K available on the Investor Relations section of www.express-scripts.com.

This is because interest rate changes have their largest effect on inflation risk, while stronger macroprudential settings will lead to a higher quality of household indebtedness over time.

«t's actually quite hard to figure out how much of the change in median household incomes over time is due to Simpson's Paradox - type composition effects»

Often these effects change over time — new information, new circ umstances, new beliefs.

Although these processes will continue to change over time, parenting can have important positive effects even when children have inherited a genetic vulnerability to problematic behaviors.»

Individual growth curve models were developed for multilevel analysis and specifically designed for exploring longitudinal data on individual changes over time.23 Using this approach, we applied the MIXED procedure in SAS (SAS Institute) to account for the random effects of repeated measurements.24 To specify the correct model for our individual growth curves, we compared a series of MIXED models by evaluating the difference in deviance between nested models.23 Both fixed quadratic and cubic MIXED models fit our data well, but we selected the fixed quadratic MIXED model because the addition of a cubic time term was not statistically significant based on a log - likelihood ratio test.

This means that even small sleep changes, over time, will have significant negative effects.

The house effects of different pollsters change over time.

That's according to new research suggesting that irises, rather than being stable over a lifetime, are susceptible to ageing effects that steadily change their appearance over time.

The goal is two-fold: One, get samples from the sand sheet and learn more about how ash and other particles that landed there from a nearby volcano have changed over time, especially from the effects of wind — a common, persistent weathering agent on Mars.

As microglia are very long - lived, the scientists were keen to find out whether environmental factors change these immune cells over time and what effect this can have on brain health.

«But what's interesting is that we find that the substitutions that have small effects change over time.»

About two - thirds of the team effect is consistent over time, with the rest caused by teams changing year - on - year.

Two studies presented at the Biology of Genomes meeting here last week show how our genomes have changed over centuries or decades, charting how since Roman times the British have evolved to be taller and fairer, and how just in the last generation the effect of a gene that favors cigarette smoking has dwindled in some groups.

By studying access to care and health outcomes for five years after health reform took effect in Massachusetts, the authors also were able to distinguish how access to care and health outcomes changed over time.

With slow environmental change, the indirect effects of species on the evolution of other species may help mutualistic interactions persist over long periods of time.

Sometimes small changes in landscape irrigation practices, such as calibrating your sprinklers to apply the recommended amount, may seem like they would have minimal effect, but consumers can see reductions in their water use, especially when they consider the cumulative effect of small changes over time.»

With the advent of more and more sophisticated ways to measure genetic variation and relatedness using molecular markers, such as allozyme polymorphisms and DNA - based markers, not only can individuals be tracked as to their parentage, but changes in allele patterns over time and thus the effects of evolution on populations can be «seen» in the genetic information.

«This is not a sensational «cephalopods are taking over the world's oceans» story,» says Paul Rodhouse, a biological oceanographer with the British Antarctic Survey in Cambridge, U.K. Further climate change could have unpredictable effects, squeezing generation times to less than a year and throwing off some species» annual mating gatherings in the process.

The researchers also examined how the effects of deforestation on microbial biodiversity change over time.

These historical milking grounds can also be used to study the effects of plant community changes on carbon storage over large time scales.

Pound for pound, the effect of methane on climate change is more than 20 times greater than carbon dioxide over a 100 - year period, according to the Environmental Protection Agency.

I guess I am surprised that with better understanding of the importance of water vapor feedback, sulfate aerosols, black carbon aerosols, more rapid than expected declines in sea ice and attendant decreases in albedo, effects of the deposition of soot and dust on snow and ice decreasing albedo, and a recognition of the importance of GHGs that were probably not considered 30 years ago, that the sensitivity has changed so little over time.

What we are developing now are a really unique set of tools that are going to allow us to monitor the changes in the retina at the cellular scale over time in the same person; and we think that this is really going to have a transformative effect because it's not only very powerful from the statistical point of view but it really is going to allow us to do experiments that were not possible before.

The net result of these complex, interacting effects is likely to vary from place, and change over time.

«They're pretty evenly distributed across the atmosphere,» said Stephen Montzka, a NOAA scientist who monitors global changes in HFCs and studies their radiative forcing effects over time.

The effects are temporary, but can contribute to a change in overall hamstring length over time.

Of the countless changes that follow a newborn, I've learned our relationships tend to have a boiling frog effect; nothing really noticeable at first, but over time — we're both wondering what went wrong.

At NeckSolutions, we hope to provide some quality advice and neck pain relief products so that you should be able to effect enough change over a period of time to correct these problems.

As Claude Bernard would say, the fat cells would be living in a different milieu intérieur and this will effect how they change over time.

Since bile salts are resorbed from the small intestine, 115 effects of bile supplementation are cumulative and the dose would change over time.

It might seem counterintuitive, but reducing cardio and increasing resistance training can have a dramatic effect for women with PCOS when it comes to total calories burned in a day, and also the changes in body composition over time.

Yet given the depth and complexity of the plot, it doesn't take much to predict that Jake will change his attitude about spying on the Na» vi before the Colonel's time limit is over — necessitating of course, a huge battle scene with lots of opportunity for more visual effects.

To isolate the effects of an SFJ on districts within each poverty quartile, we focus on changes in spending over time within specific school districts after taking into account changes from year to year in average education spending across all of the nation's school districts.

We also include student fixed effects, which account for changes in the composition of the schools» student populations over time that can not be explained by the limited set of student characteristics for which information was available in the district's database.

Maintains an expectation that there will be accountability and action to effect positive change in our lowest - performing schools, where groups of students are not making progress, and where graduation rates are low over extended periods of time.

According to Hattie the story underlying the data has hardly changed over time even though some effect sizes were updated and we have some new entries at the top, at the middle, and at the end of the list.

Similarly, Russ Whitehurst and Michelle Croft have shown that the quality of state standards (as assessed by third party organizations) is unrelated to NAEP scores, a finding confirmed by the Harvard Kennedy School's Josh Goodman in an analysis that examined the effects of changes in the quality of standards within states over time.

Just a little incremental change every year on the part of the teacher, over time, you know, would have this cumulative effect on student achievement where you'd say that, «Hey, in this district, in this school, we know that our teachers are getting better every year.

The effects will change over time; no one study proves anything.

While NAEP scores are widely cited, score changes over time can be a reflection of trends outside the classroom, such as changing demographics, attrition, measurement error and changes in circumstances, including the effects of the recession.

It just seems very difficult to be confident in ROIC or reinvestment rate adjustments going out over such a time period, where small changes in assumptions would produce outsized effects on your projected earnings power.

Mild movements in interest rates will often have a minimal effect on the price of bonds whereas abrupt swings in interest rates, market sentiment or investor fears, as we've observed in markets recently, can change the valuations of bonds dramatically over a short period of time.

But if that government bond goes to 10 %, it changes the value of this equity bond that, in effect, you're buying... when you buy an interest in... anything, you are buying something that, over time, is going to return cash to you... And those are the coupons.

The LLLT works in a 4 - 5 step process, just like taking medicine that works on the body over time to effect change.