In the Science study, led by first author Nan Cao, PhD, a postdoctoral fellow in Ding's lab, the researchers used a cocktail of nine chemicals to
change human skin cells into beating heart cells.
Using a mathematical model known as the Ising model, invented to describe phase transitions in statistical physics, such as how a substance
changes from liquid to gas, the Johns Hopkins researchers calculated the probability distribution of methylation along the genome in several different
human cell types, including normal and cancerous colon, lung and liver
cells, as well as brain,
skin, blood and embryonic stem
cells.