Sentences with phrase «change impacts mixed»

But the political messages coming from groups from two Asian nations on the forefront of climate change impacts mixed in with speeches from climate activists was poignant.

Not exact matches

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

These risks include, in no particular order, the following: the trends toward more high - definition, on - demand and anytime, anywhere video will not continue to develop at its current pace or will expire; the possibility that our products will not generate sales that are commensurate with our expectations or that our cost of revenue or operating expenses may exceed our expectations; the mix of products and services sold in various geographies and the effect it has on gross margins; delays or decreases in capital spending in the cable, satellite, telco, broadcast and media industries; customer concentration and consolidation; the impact of general economic conditions on our sales and operations; our ability to develop new and enhanced products in a timely manner and market acceptance of our new or existing products; losses of one or more key customers; risks associated with our international operations; exchange rate fluctuations of the currencies in which we conduct business; risks associated with our CableOS ™ and VOS ™ product solutions; dependence on market acceptance of various types of broadband services, on the adoption of new broadband technologies and on broadband industry trends; inventory management; the lack of timely availability of parts or raw materials necessary to produce our products; the impact of increases in the prices of raw materials and oil; the effect of competition, on both revenue and gross margins; difficulties associated with rapid technological changes in our markets; risks associated with unpredictable sales cycles; our dependence on contract manufacturers and sole or limited source suppliers; and the effect on our business of natural disasters.

In the Doug Purvis Memorial Lecture, Governor Stephen S. Poloz shows how changing the mix of monetary and fiscal policies can yield the same outcomes for growth and inflation, but lead to different results for public sector and private sector debt levels, which can impact financial stability.

If I take Keystone XL out of the mix, in my toy model, I haven't impacted the cost of the marginal barrel of oil sands because I haven't changed the cost of a barrel shipped by rail, I've simply reduced the profit on the barrels which would be shipped via KXL by forcing them to be shipped to market in a more expensive way.

«The change towards multifamily could be the initial signs that affordability is starting to impact the mix of construction,» noted Tendayi Kapfidze, chief economist at LendingTree.

However, he said the MLS home price index composite benchmark, which strips out the impact of changes in the mix of home sales, was down 5.2 % compared with a year ago and the number of new listings in April had plunged to 16,273, a 24.6 % decrease from the 21,571 listings seen last year at the same time.

The average price was impacted by two factors, the TREB said: by «changes in market conditions,» and by the sales collapse at the higher end of the market, which changed the mix of sales, and therefore affected the average price.

The TREB's proprietary Home Price Index, which is based on a «composite benchmark home,» and which «strips out» the impact of these changes in mix, «was down by only 5.2 %» year - over-year.

In particular, changes in how mixed foods have been split into separate components will impact some comparisons.

There have been many social and behavior change efforts to engage men in reproductive health program interventions, but evidence regarding the impact on breastfeeding practice is mixed [1, 14].

However, determining just how, and by how much, has yielded mixed results — not only because of questions around the realism of related studies, but also because parsing the contributing impacts of other threats to bees, such as climate change, has been difficult.

«Ice age vertebrates had mixed responses to climate change: New study contradicts idea of uniform population change, has significance for understanding global warming impact.»

«With the hydrological cycle projected to change under global warming, impacting upper - ocean stratification and mixing, the results from this study have potentially important implications for understanding future tropical cyclone activity.»

The authors recommend a shift in focus for TFA from a program of mixed impact to one that makes measureable changes in the quality of education in America.

The impact on suppliers will differ significantly based on their product areas and their adaptability to these changes in mix.

Risks and uncertainties include without limitation the effect of competitive and economic factors, and the Company's reaction to those factors, on consumer and business buying decisions with respect to the Company's products; continued competitive pressures in the marketplace; the ability of the Company to deliver to the marketplace and stimulate customer demand for new programs, products, and technological innovations on a timely basis; the effect that product introductions and transitions, changes in product pricing or mix, and / or increases in component costs could have on the Company's gross margin; the inventory risk associated with the Company's need to order or commit to order product components in advance of customer orders; the continued availability on acceptable terms, or at all, of certain components and services essential to the Company's business currently obtained by the Company from sole or limited sources; the effect that the Company's dependency on manufacturing and logistics services provided by third parties may have on the quality, quantity or cost of products manufactured or services rendered; risks associated with the Company's international operations; the Company's reliance on third - party intellectual property and digital content; the potential impact of a finding that the Company has infringed on the intellectual property rights of others; the Company's dependency on the performance of distributors, carriers and other resellers of the Company's products; the effect that product and service quality problems could have on the Company's sales and operating profits; the continued service and availability of key executives and employees; war, terrorism, public health issues, natural disasters, and other circumstances that could disrupt supply, delivery, or demand of products; and unfavorable results of other legal proceedings.

So if the mix of BookBub categories where indies are featured has also changed substantially over time, the impact on indie ebook sales and earnings could be less than or greater than what deal count alone would indicate.

I suppose it's true that some sort of change is in order, since you have failed to convince the financial blog community, but as is often the case with you, I'm not at all convinced that you are applying sound reasoning in assuming that the frothy mix of politics is the right place to take your war on passive index investing; which is about the most benign thing a person could do, and one that I am not sure can be outlawed without significant impact on our basic personal freedoms!

Any modifications to any mix of investments should be made gradually to lessen the impact of significant market changes and potential tax effects.

For baby boomers who are nearing retirement, saving more and adjusting their asset mix has less impact for the simple reason that they have less time for those changes to impact accumulated wealth — though it may still help.

In color theory and color mixing workshops, guests will see firsthand how colors impact each other — what happens when colored paints are combined and how does our perception of one color change by simply placing it next to another.

His works still resonate a passion mixed with righteous anger, symbolic ingenuity, high visual impact, intelligence in the details, color - tastic cacophony and multi-cultural reach that is unrivaled by any other artist that changed the face of art back in the 80's.

As author and co-editor of a new fire book, «The Ecological Importance of Mixed - Severity Fires — Nature's Phoenix,» I would like to comment on Lindon's hypothesis that by «controlling» fire we can reduce climate change impacts.

The advantage of the ocean heat content changes for detecting climate changes is that there is less noise than in the surface temperature record due to the weather that affects the atmospheric measurements, but that has much less impact below the ocean mixed layer.

The bottom line — in sync with other recent analysis — is that the region is seeing a mix of changes, with glaciers growing in some places and shrinking in others and impacts on water supplies mostly inconsequential for decades to come.

Climate change impacts often mix with conflict to trap people in endless cycles of displacement.

It is a touch wishful to model the impact of a 0.028 % change in a mixed gas composition when you are not all that sure what the other 99.972 % does.

This Assessment makes it clear that the impacts of future climate change will be mixed across regions.

More often, however, the impacts of multiple influences are mixed together, and further confused by imperfect knowledge of how each of them has changed, and uncertainties in how climate itself has varied.

New York State energy planning based on the Reforming the Energy Vision goal to change the energy system of New York to reduce greenhouse gas (GHG) emissions 80 % from 1990 levels by 2050 is trying to choose between many expensive policy options like pricing carbon in the electric sector while at the same time attempting to understand which one (or what mix) will be the least expensive and have the fewest negative impacts on the existing system.

This year, WEO - 2017 includes a special focus on China, where economic and energy policy changes underway will have a profound impact on the country's energy mix, and continue to shape global trends.

Topics that I work on or plan to work in the future include studies of: + missing aerosol species and sources, such as the primary oceanic aerosols and their importance on the remote marine atmosphere, the in - cloud and aerosol water aqueous formation of organic aerosols that can lead to brown carbon formation, the primary terrestrial biological particles, and the organic nitrogen + missing aerosol parameterizations, such as the effect of aerosol mixing on cloud condensation nuclei and aerosol absorption, the semi-volatility of primary organic aerosols, the importance of in - canopy processes on natural terrestrial aerosol and aerosol precursor sources, and the mineral dust iron solubility and bioavailability + the change of aerosol burden and its spatiotemporal distribution, especially with regard to its role and importance on gas - phase chemistry via photolysis rates changes and heterogeneous reactions in the atmosphere, as well as their effect on key gas - phase species like ozone + the physical and optical properties of aerosols, which affect aerosol transport, lifetime, and light scattering and absorption, with the latter being very sensitive to the vertical distribution of absorbing aerosols + aerosol - cloud interactions, which include cloud activation, the aerosol indirect effect and the impact of clouds on aerosol removal + changes on climate and feedbacks related with all these topics In order to understand the climate system as a whole, improve the aerosol representation in the GISS ModelE2 and contribute to future IPCC climate change assessments and CMIP activities, I am also interested in understanding the importance of natural and anthropogenic aerosol changes in the atmosphere on the terrestrial biosphere, the ocean and climate.

«Technology and changing client demands will impact the mix and skillset of staff required and, indeed, artificial intelligence resourcing tools may ultimately help firms to achieve optimal staffing.»

Careful readers of Slaw will have noted the blog post by Andrew Langille included in this week's Monday Mix, suggesting that the impact of a federal change could be larger than sometimes alleged.

The specific energy mix of hydro, wind, solar, natural gas, nuclear, and coal specific to each region is different, which alters the impact of certain changes in government policy, and of changes to the home.

, but we teamed up with Home Depot Canada, found some gorgeous Behr paint in Ink Black and Polar Bear, and my fave new mixed - metal pendant light, and made a small change with a big impact.