Sentences with phrase «change in expression»

The analysis revealed that several functions were associated with more or fewer genes in cancer cells than in healthy cells, but not because of changes in the expression of these genes.

While some genes important to cancer development have clear alterations in their genetic codes to explain changes in their expression in cells, some do not exhibit such defined defects.

The brain attempts to adapt and respond to those challenges and that occurs in large part through changes in expression of brain genes through epigenetic mechanisms.

It is widely expressed in the body, but changes in its expression mostly affect the brain.

But the researchers found no significant changes in the expression of genes known to be involved in calcification from prior studies comparing strains with dramatically different calcification levels.

The plasma amino acids were similar in wild - type and knockout mice and there were no major compensatory changes in the expression of other amino acid transporter mRNAs.

The study shows that even small, tissue - specific changes in the expression of genes can have noticeable morphological effects.

Mass spectrometry is an extremely powerful and sensitive technology that can detect very small changes in expression levels.

The presence of SCNT - derived conceptus in the uterus caused changes in the expression levels of more genes in caruncular and intercaruncular tissues at d 34 than at d 18 of the pregnancy (Table 2).

Finally, the team identified a network of genes in these regions that exhibit changes in expression when the normal boost from serotonin is lacking, and these changes depended on how long the drug was given.

Its appearance following starvation and other stresses is associated with changes in the expression of over 500 genes, most prominently genes for the structural RNAs that are components of the ribosome — the enzyme responsible for protein synthesis.

Sophie not only asked questions of job candidates, but it also studied their faces for changes in expressions that could indicate whether they may be fibbing.

While changes in the expression of several hundred genes were detected by microarray analyses, in the study by D'Mello and colleagues over 4,000 genes displayed significantly altered expression.

Other rodent models that utilize changes in expression of α - synuclein have also reported lower anxiety levels.

31 of the tRNA molecules varied in expression between males and females across all strains, and two tRNA molecules showed significant changes in expression based on developmental stage.

In vivo versus in vitro protein abundance analysis of Shigella dysenteriae type 1 reveals changes in the expression of proteins involved in virulence, stress and energy metabolism.

Further, it would suggest that sex - specific morphology can evolve by spatially regulated changes in expression within the sex - determining pathway without disrupting other sex - determination functions.

Bioinformatics approaches were then used to compare the proteomics data to sample - matched transcriptomics data to identify targets of post-transcriptional control and provide quantitative information on changes in the expression pattern of targets at the level of translation.

Of equal importance, XJB -5-131 protected human primary TM cells against TGF - β2 mediated changes in expression of specific extracellular matrix proteins.

GSE56612) contained information on 391 solute transporters, a majority of them showing no significant change in expression between the two groups.

Robust changes in expression of brain - derived neurotrophic factor (BDNF) mRNA and protein across the brain do not translate to detectable changes in BDNF levels in CSF or plasma.

Delon's nuanced performance moves easily between suave and sinister, often with just a minor change in expression, provides the perfect front for an utterly amoral killer.

For example, Izukori mentions the «eye - candy» appeal of Final Fantasy characters, however noting «the slightest minute change in expression can be seen as a negative» when it comes to achieving that direction.

Usually, he chooses to go for the nose and eyes at an early stage, and by the time he reaches the mouth, the subtle change in the expression may have already taken effect, so a portion of ambiguity can appear in the piece.

Moreover, for the first time, they show that changes in whole - organism phenotypic responses are accompanied by changes in the expression of genes related to intracellular regulatory processes rather than genes thought to be essential for calcification.

However, epigenetic changes at a single gene promoter are unlikely to account for the range of outcomes and the persistent change in expression of hundreds of additional genes in adult rats in response to differences in maternal care.

This effect is not associated with compensatory changes in the expression of any other amino acid transporter.

Dr. Steven R. Goodman, Editor - in - Chief of Experimental Biology and Medicine said «D'Mello and colleagues have performed a transcriptomic study, utilizing RNA - Seq, to identify transcripts that are changed in expression in dying neurons.

Gene moonlighting can occur merely through changes in expression, which may result from as little as a single mutation; it does not require the meandering process of random alteration and selection implied by the duplication and neofunctionalization model.

Because they influence the activity of many «downstream» genetic targets, small changes in the expression of these regulatory genes can have an enormous impact.

The researchers also showed that regular feeding with the Lactobacillus strain caused changes in the expression of receptors for the neurotransmitter GABA in the mouse brain, which is the first time that it has been demonstrated that potential probiotics have a direct effect on brain chemistry in normal situations.

Antagonists of growth hormone releasing hormone (GHRH) given before whole body radiation lead to modulation of radiation response and organ - specific changes in the expression of angiogenesis.

Utilizing this very sensitive technique they were able to demonstrate significant changes in the expression of over 4000 genes.

In colon and lung of the knockout mice, there were no major compensatory changes in the expression of any of the 12 amino acid transporter mRNAs examined (Figure 1C).

They firmly believed that, though some changes in the expression of Christian doctrine were needed, the essential truth of Christianity would stand firm and would be expressed again in new and more appropriate forms.

Also notice the change in expression on Lukaku's face after spotting the boss.

Prolonged oral administration of a pan-retinoic acid receptor antagonist inhibits spermatogenesis in mice with a rapid recovery and changes in the expression of influx and efflux transporters.

Hockemeyer says that it's unlikely to be another mutation, but rather an epigenetic change that affects expression of the telomerase gene, or a change in the expression of a transcription factor or other regulatory proteins that binds to the promoter upstream of the telomerase gene.

«We also found that reduced cohesin led to changes in the expression of genes involved in nerve cell development and the response to an immune signaling protein,» corresponding author Toshihide Yamashita says.

These changes in expression levels allow the bacteria to alter their composition to better survive stress.

Based on the CT based anatomical observations in probainognathians, it appears that the MSX2 gene underwent a significant change in its expression 240 - 246 million years ago and triggered the evolution of many typical mammalian traits including hair and whiskers, an enlarged cerebellum, complete ossification of the skull roof, and more importantly, the mammary glands, that define mammals today.

«What we observed is that the levels of many miRNAs change significantly throughout the 48 - hour period following a blood meal, indicating that these miRNAs, in turn, may be establishing significant changes in expression of key genes during this time in the fat body,» said Fedor V. Karginov, an assistant professor of cell biology and neuroscience, who co-led the research team along with Alexander S. Raikhel, a distinguished professor of entomology at UC Riverside.