Sentences with phrase «change in gene expression»

Then, she was more interested in the rapid change in gene expression patterns stimulated by environmental stress, which is anything but subtle.

So the capacity of an organism to adapt to an environment is mediated through epigenetic changes in gene expression.

Within the cell, they can trigger changes in gene expression and biochemical reactions, among other things.

The early stages of animal development are characterized by dramatic changes in gene expression.

To defeat cancer, we need a therapy that does not depend on anything that a cancer could escape through a mutation - driven change in gene expression.

As the worms aged, the team observed dramatic changes in gene expression.

Additionally, the interpretation of levels of change in gene expression in isolation, without the additional statistical rigor provided by the concomitant analysis of ontological interaction networks, may severely limit critical insights into relevant biologic processes.

«One outcome of our approach is that we find a characteristic timescale of changes in gene expression for each gene.

Abnormalities in the structure of chromosomes are known to cause changes in gene expression during development of nerve cell networks.

Susana Zanello, Universities Space Research Association scientist at NASA's Johnson Space Center in Houston, examined eye tissue for changes in gene expression in the retina — the sensory tissue at the back of the eye.

Conclusions: Cold - induced changes in gene expression in inguinal WAT are unaltered in mice lacking PPARα, indicating that PPARα is dispensable for cold - induced browning.

These variants cause significant changes in gene expression in a human neuroblastoma cell line, likely due to disrupted transcription factor binding.

This allowed the team to correlate changes in gene expression with subsequent alterations in the patient's clinical condition.

They found similar changes in gene expression in the same genes with increased activity of glucose transporters in both the stem cells and the fat cells, Sen noted.

By determining how changes in gene expression affect the fate of glial cells in mice, we hope to understand the key factors that govern neural cell regeneration in the human brain.

To measure changes in gene expression from different species, White and Gilad developed the first multi-species gene array.

It is not clear which exact biomarker or combination of biomarkers is responsible for changes in the gene expression as there is a lot happening in the intestinal soup.

The theory proposed by Professor Khavinson is based on the underlying assumption that changes in gene expression result in decreased protein synthesis, eventually leading to aging and the development of diseases.

DNA microarray was used to evaluate changes in gene expression following one hour of treatment of HT22 neuronal cells with 10 μM J147.

The genomics era has had a profound impact on life science research, leading to significant developments such as the use of expression quantitative trait loci (eQTLs), which link polymorphisms in single genes to quantifiable changes in gene expression associated with specific diseases.

«We observed small but significant changes in the gene expressions between normal and diabetic corneas,» said Mehrnoosh Saghizadeh Ghiam, PhD, assistant professor of biomedical sciences and neurosurgery, a researcher in the Regenerative Medicine Institute Eye Program and the lead author of the study published in the journal PLOS ONE.

Additionally, using RNA - Seq, we determined changes in gene expression levels between the wild - type (WT) and DAXX knock - down (K / D) PC3 cells.

Dr Gilchrist said: «This study suggests that we may improve significantly on the widely used analysis methods for determining gene expression levels from high throughput sequence data: absolute quantitation offers a much sounder basis for determining changes in gene expression level, a measure widely used to determine the consequence of genetic, chemical or physical disturbances in living systems.»

The purpose of this study was to identify changes in gene expression induced by hypoxia in rat retina both immediately following hypoxia as well as following a 24 h recovery period post hypoxia.

To better visualize changes in gene expression programs during differentiation, we performed k - means clustering analysis, followed by hierarchical clustering, to group genes by their timing of induction or suppression during the normal ES cell differentiation process.

CRISPRi also did not cause any off - target changes in gene expression, like undesired insertions or deletions to the cell's genome, which is a concern with CRISPR - Cas9.

One way for that to happen is through changes in gene expression, but changes in phosphorylation are equally effective,» explains Beltrao.

Such a mechanism could turn chemical ephemera — the ebbing and flowing of calcium ions and gentle currents of nitric oxide — into changes in gene expression and finally into alterations in the «wiring» of the nervous system.

These reporters will give us the ability to sort infected cultures to analyze changes in gene expression in directly infected cells and bystander cells and compare to uninfected cells.

«What George's team has accomplished is a technological tour de force,» said Wyss Institute Founding Director Don Ingber, M.D., Ph.D. «By spotting incredibly subtle but incredibly important changes in gene expression and precisely defining their position inside the cell, they have helped open the door to a new age of cellular diagnostics.»

«It's intuitive that taking a vacation reduces biological processes related to stress, but it was still impressive to see the large changes in gene expression from being away from the busy pace of life, in a relaxing environment, in such a short period of time.

He has more recently also been studying changes in gene expression with microarrays during epileptogenesis.

This is just the first of a series of similar studies, said Gilad, that will look at changes in gene expression over evolutionary time.

They compared changes in gene expression in 37 of them who developed suicidal feelings with previously published work and with post-mortem samples of 26 men who had killed themselves.

The authors describe dengue as inducing more robust changes in gene expression than either strain of Zika.

The article «Rapid changes in gene expression direct rapid shifts in intestinal form and function in the Burmese python after feeding» is published in the May issue of Physiological Genomics, a journal of the American Physiological Society (APS).

«These convergent changes in gene expression and protein sequences could be introduced into plants that rely on traditional photosynthesis, accelerating their evolution to become more water - use efficient,» said Yang.

A distinctive pattern of changes in gene expression occurs in those RA patients who have a good - response to a TNF inhibitor at three months, but not in non-responders

This gave us an unprecedented opportunity to chart changes in gene expression spanning the course of a lifetime.»

«And they actually show changes in gene expression that have been previously implicated in brain aging.»

The team found significant changes in gene expression after light exposure in all cell types in the visual cortex — both neurons and, unexpectedly, nonneuronal cells such as astrocytes, macrophages and muscle cells that line blood vessels in the brain.

Changes in gene expression do not necessarily affect health, because the body's homeostatic mechanisms may compensate.

«Based on these seemingly ordered changes in gene expression, we wanted to find out what might be driving the emergence of the 2 - cell - like state.

By examining changes in gene expression, they showed that one of the duplicated genes, HOXB8, which is known to function in feather development, was present at high levels in the facial skin of chickens with Muffs and beard, but not in regular chickens.

«Instead, the benefit we see after PD - 1 pathway blockade is caused by only transient changes in gene expression that is not durable, rather than permanent epigenetic reprogramming.»

«Our hypothesis was, if a disease is characterized by certain changes in gene expression and if a drug causes the reverse changes, then that drug could have a therapeutic effect on the disease,» he says.

To work out the genetic basis, Duke University postdoctoral associate Bob Fitak and biology professor Sönke Johnsen and colleagues investigated changes in gene expression that take place across the rainbow trout genome when the animal's magnetic sense is disrupted.