Several trials have demonstrated that the cardiomyocytes of rodents maintained
on IER become more resilient to ischaemic injury induced by occlusion of the left coronary artery 18, 21, 29, which translated into improved long - term survival following such injury in one study.21 In addition, within these studies, associations have been found between the
cardiovascular improvements and markers of oxidative stress 24, 30, inflammatory responses 18, 24, 29, 30 and increases in circulating levels of adiponectin.29 Collectively, these reported
changes in biochemical and physiological
cardiovascular risk factors would be expected to suppress atherosclerotic development and preserve
cardiovascular health.