Sentences with phrase «change over the current year»

Not exact matches

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

As soon as this year's tax season is over, book an appointment with your CPA to talk about changes you can make in the current year.

[01:10] Introduction [02:45] James welcomes Tony to the podcast [03:35] Tony's leap year birthday [04:15] Unshakeable delivers the specific facts you need to know [04:45] What James learned from Unshakeable [05:25] Most people panic when the stock market drops [05:45] Getting rid of your fear of investing [06:15] Last January was the worst opening, but it was a correction [06:45] You are losing money when you sell on corrections [06:55] Bear markets come every 5 years on average [07:10] The greatest opportunity for a millennial [07:40] Waiting for corrections to invest [08:05] Warren Buffet's advice for investors [08:55] If you miss the top 10 trading days a year... [09:25] Three different investor scenarios over a 20 year period [10:40] The best trading days come after the worst [11:45] Investing in the current world [12:05] What Clinton and Bush think of the current situation [12:45] The office is far bigger than the occupant [13:35] Information helps reduce fear [14:25] James's story of the billionaire upset over another's wealth [14:45] What money really is [15:05] The story of Adolphe Merkle [16:05] The story of Chuck Feeney [16:55] The importance of the right mindset [17:15] What fuels Tony [19:15] Find something you care about more than yourself [20:25] Make your mission to surround yourself with the right people [21:25] Suffering made Tony hungry for more [23:25] By feeding his mind, Tony found strength [24:15] Great ideas don't interrupt you, you have to pursue them [25:05] Never - ending hunger is what matters [25:25] Richard Branson is the epitome of hunger and drive [25:40] Hunger is the common denominator [26:30] What you can do starting right now [26:55] Success leaves clues [28:10] What it means to take massive action [28:30] Taking action commits you to following through [29:40] If you do nothing you'll learn nothing [30:20] There must be an emotional purpose behind what you're doing [30:40] How does Tony ignite creativity in his own life [32:00] «How is not as important as «why» [32:40] What and why unleash the psyche [33:25] Breaking the habit of focusing on «how» [35:50] Deep Practice [35:10] Your desired outcome will determine your action [36:00] The difference between «what» and «why» [37:00] Learning how to chunk and group [37:40] Don't mistake movement for achievement [38:30] Tony doesn't negotiate with his mind [39:30] Change your thoughts and change your biochemistry [40:00] The bad habit of being stressed [40:40] Beautiful and suffering states [41:50] The most important decision is to live in a beautiful state no matter what [42:40] Consciously decide to take yourself out of suffering [43:40] Focus on appreciation, joy and love [44:30] Step out of suffering and find the solution [45:00] Dealing with mercury poisoning [45:40] Tony's process for stepping out of suffering [46:10] Stop identifying with thoughts — they aren't yours [47:40] Trade your expectations for appreciation [50:00] The key to life — gratitude [51:40] What is freedom foChange your thoughts and change your biochemistry [40:00] The bad habit of being stressed [40:40] Beautiful and suffering states [41:50] The most important decision is to live in a beautiful state no matter what [42:40] Consciously decide to take yourself out of suffering [43:40] Focus on appreciation, joy and love [44:30] Step out of suffering and find the solution [45:00] Dealing with mercury poisoning [45:40] Tony's process for stepping out of suffering [46:10] Stop identifying with thoughts — they aren't yours [47:40] Trade your expectations for appreciation [50:00] The key to life — gratitude [51:40] What is freedom fochange your biochemistry [40:00] The bad habit of being stressed [40:40] Beautiful and suffering states [41:50] The most important decision is to live in a beautiful state no matter what [42:40] Consciously decide to take yourself out of suffering [43:40] Focus on appreciation, joy and love [44:30] Step out of suffering and find the solution [45:00] Dealing with mercury poisoning [45:40] Tony's process for stepping out of suffering [46:10] Stop identifying with thoughts — they aren't yours [47:40] Trade your expectations for appreciation [50:00] The key to life — gratitude [51:40] What is freedom for you?

For the rest of the Golden State, the current caps will be carried over into next year with no changes whatsoever.

If we stay on our current emission pathway, this will change: The metro region will likely see 2 to 7 extremely hot days on average over the next 5 to 25 years, 4 to 17 such days likely by mid-century, and 11 to 59 days — nearly two months — over 95 °F likely by the end of the century.

The changes to the forecasts for inflation over the years to June 2000 and June 2001 (excluding the effect of the GST) appear to reflect current and prospective developments in oil and tobacco prices as well as a modest increase in the assessment of underlying inflationary pressures.

Liz and I will chat about her travels around the globe, how she's seen the movement change over the years, coworking trends in different geographies and the current state of our movement.

As a rough guide to how prospective returns will change over the completion of the current market cycle, we presently estimate that in order to establish expected 10 - year S&P 500 total returns of 5 % annually, the S&P 500 would have to decline to the mid-1500's.

So does that mean since a bunch of rogue nuns with feminist ideals taught over the last 50 years should force the Church to change its current teaching on euthanasia, gay marriage, and abortion?

A new study that looks at climate change over the past 11,300 years — a record length of time for any study — suggests that the current trend of global warming is unprecedented.

The ordering process utilises several elements: the current sales over the last four to six weeks, the sales trend over the last few months, the comparable sales trends from the previous year and any customer forecasts or anticipated changes in demand noted by a change in season.

Over the last two years, scientists from the United States, the United Kingdom, and Sweden have examined projections and current data to identify ways in which the dairy industry may respond to challenges such as population growth, urbanisation, and climate change, in order to meet increased demand for dairy products over the next half centOver the last two years, scientists from the United States, the United Kingdom, and Sweden have examined projections and current data to identify ways in which the dairy industry may respond to challenges such as population growth, urbanisation, and climate change, in order to meet increased demand for dairy products over the next half centover the next half century.

This is an incredibly difficult question to answer for a variety of reasons, most importantly because over the years our once vaunted «beautiful» style of play has become a shadow of it's former self, only to be replaced by a less than stellar «plug and play» mentality where players play out of position and adjustments / substitutions are rarely forthcoming before the 75th minute... if you look at our current players, very few would make sense in the traditional Wengerian system... at present, we don't have the personnel to move the ball quickly from deep - lying position, efficient one touch midfielders that can make the necessary through balls or the disciplined and pacey forwards to stretch defences into wide positions, without the aid of the backs coming up into the final 3rd, so that we can attack the defensive lanes in the same clinical fashion we did years ago... on this current squad, we have only 1 central defender on staf, Mustafi, who seems to have any prowess in the offensive zone or who can even pass two zones through so that we can advance play quickly out of our own end (I have seen some inklings that suggest Holding might have some offensive qualities but too early to tell)... unfortunately Mustafi has a tendency to get himself in trouble when he gets overly aggressive on the ball... from our backs out wide, we've seen pace from the likes of Bellerin and Gibbs and the spirited albeit offensively stunted play of Monreal, but none of these players possess the skill - set required in the offensive zone for the new Wenger scheme which requires deft touches, timely runs to the baseline and consistent crossing, especially when Giroud was playing and his ratio of scored goals per clear chances was relatively low (better last year though)... obviously I like Bellerin's future prospects, as you can't teach pace, but I do worry that he regressed last season, which was obvious to Wenger because there was no way he would have used Ox as the right side wing - back so often knowing that Barcelona could come calling in the off - season, if he thought otherwise... as for our midfielders, not a single one, minus the more confident Xhaka I watched played for the Swiss national team a couple years ago, who truly makes sense under the traditional Wenger model... Ramsey holds onto the ball too long, gives the ball away cheaply far too often and abandons his defensive responsibilities on a regular basis (doesn't score enough recently to justify): that being said, I've always thought he does possess a little something special, unfortunately he thinks so too... Xhaka is a little too slow to ever boss the midfield and he tends to telegraph his one true strength, his long ball play: although I must admit he did get a bit better during some points in the latter part of last season... it always made me wonder why whenever he played with Coq Wenger always seemed to play Francis in a more advanced role on the pitch... as for Coq, he is way too reckless at the wrong times and has exhibited little offensive prowess yet finds himself in and around the box far too often... let's face it Wenger was ready to throw him in the trash heap when injuries forced him to use Francis and then he had the nerve to act like this was all part of a bigger Wenger constructed plan... he like Ramsey, Xhaka and Elneny don't offer the skills necessary to satisfy the quick transitory nature of our old offensive scheme or the stout defensive mindset needed to protect the defensive zone so that our offensive players can remain aggressive in the final third... on the front end, we have Ozil, a player of immense skill but stunted by his physical demeanor that tends to offend, the fact that he's been played out of position far too many times since arriving and that the players in front of him, minus Sanchez, make little to no sense considering what he has to offer (especially Giroud); just think about the quick counter-attack offence in Real or the space and protection he receives in the German National team's midfield, where teams couldn't afford to focus too heavily on one individual... this player was a passing «specialist» long before he arrived in North London, so only an arrogant or ignorant individual would try to reinvent the wheel and / or not surround such a talent with the necessary components... in regards to Ox, Walcott and Welbeck, although they all possess serious talents I see them in large part as headless chickens who are on the injury table too much, lack the necessary first - touch and / or lack the finishing flair to warrant their inclusion in a regular starting eleven; I would say that, of the 3, Ox showed the most upside once we went to a back 3, but even he became a bit too consumed by his pending contract talks before the season ended and that concerned me a bit... if I had to choose one of those 3 players to stay on it would be Ox due to his potential as a plausible alternative to Bellerin in that wing - back position should we continue to use that formation... in Sanchez, we get one of the most committed skill players we've seen on this squad for some years but that could all change soon, if it hasn't already of course... strangely enough, even he doesn't make sense given the constructs of the original Wenger offensive model because he holds onto the ball too long and he will give the ball up a little too often in the offensive zone... a fact that is largely forgotten due to his infectious energy and the fact that the numbers he has achieved seem to justify the means... finally, and in many ways most crucially, Giroud, there is nothing about this team or the offensive system that Wenger has traditionally employed that would even suggest such a player would make sense as a starter... too slow, too inefficient and way too easily dispossessed... once again, I think he has some special skills and, at times, has showed some world - class qualities but he's lack of mobility is an albatross around the necks of our offence... so when you ask who would be our best starting 11, I don't have a clue because of the 5 or 6 players that truly deserve a place in this side, 1 just arrived, 3 aren't under contract beyond 2018 and the other was just sold to Juve... man, this is theraputic because following this team is like an addiction to heroin without the benefits

Arsenal have changed their formation from a classic 442 to more of a 4231 over the years, but our current three at the back system looks revolutionary for the Gunners.

Time for some brutal honesty... this team, as it stands, is in no better position to compete next season than they were 12 months ago, minus the fact that some fans have been easily snowed by the acquisition of Lacazette, the free transfer LB and the release of Sanogo... if you look at the facts carefully you will see a team that still has far more questions than answers... to better show what I mean by this statement I will briefly discuss the current state of affairs on a position - by - position basis... in goal we have 4 potential candidates, but in reality we have only 1 option with any real future and somehow he's the only one we have actively tried to get rid of for years because he and his father were a little too involved on social media and he got caught smoking (funny how people still defend Wiltshire under the same and far worse circumstances)... you would think we would want to keep any goaltender that Juventus had interest in, as they seem to have a pretty good history when it comes to that position... as far as the defenders on our current roster there are only a few individuals whom have the skill and / or youth worthy of our time and / or investment, as such we should get rid of anyone who doesn't meet those simple requirements, which means we should get rid of DeBouchy, Gibbs, Gabriel, Mertz and loan out Chambers to see if last seasons foray with Middlesborough was an anomaly or a prediction of things to come... some fans have lamented wildly about the return of Mertz to the starting lineup due to his FA Cup performance but these sort of pie in the sky meanderings are indicative of what's wrong with this club and it's wishy - washy fan - base... in addition to these moves the club should aggressively pursue the acquisition of dominant and mobile CB to stabilize an all too fragile defensive group that has self - destructed on numerous occasions over the past 5 seasons... moving forward and building on our need to re-establish our once dominant presence throughout the middle of the park we need to target a CDM then do whatever it takes to get that player into the fold without any of the usual nickel and diming we have become famous for (this kind of ruthless haggling has cost us numerous special players and certainly can't help make the player in question feel good about the way their future potential employer feels about them)... in order for us to become dominant again we need to be strong up the middle again from Goalkeeper to CB to DM to ACM to striker, like we did in our most glorious years before and during Wenger's reign... with this in mind, if we want Ozil to be that dominant attacking midfielder we can't keep leaving him exposed to constant ridicule about his lack of defensive prowess and provide him with the proper players in the final third... he was never a good defensive player in Real or with the German National squad and they certainly didn't suffer as a result of his presence on the pitch... as for the rest of the midfield the blame falls squarely in the hands of Wenger and Gazidis, the fact that Ramsey, Ox, Sanchez and even Ozil were allowed to regularly start when none of the aforementioned had more than a year left under contract is criminal for a club of this size and financial might... the fact that we could find money for Walcott and Xhaka, who weren't even guaranteed starters, means that our whole business model needs a complete overhaul... for me it's time to get rid of some serious deadweight, even if it means selling them below what you believe their market value is just to simply right this ship and change the stagnant culture that currently exists... this means saying goodbye to Wiltshire, Elneny, Carzola, Walcott and Ramsey... everyone, minus Elneny, have spent just as much time on the training table as on the field of play, which would be manageable if they weren't so inconsistent from a performance standpoint (excluding Carzola, who is like the recent version of Rosicky — too bad, both will be deeply missed)... in their places we need to bring in some proven performers with no history of injuries... up front, although I do like the possibilities that a player like Lacazette presents, the fact that we had to wait so many years to acquire some true quality at the striker position falls once again squarely at the feet of Wenger... this issue highlights the ultimate scam being perpetrated by this club since the arrival of Kroenke: pretend your a small market club when it comes to making purchases but milk your fans like a big market club when it comes to ticket prices and merchandising... I believe the reason why Wenger hasn't pursued someone of Henry's quality, minus a fairly inexpensive RVP, was that he knew that they would demand players of a similar ilk to be brought on board and that wasn't possible when the business model was that of a «selling» club... does it really make sense that we could only make a cheeky bid for Suarez, or that we couldn't get Higuain over the line when he was being offered up for half the price he eventually went to Juve for, or that we've only paid any interest to strikers who were clearly not going to press their current teams to let them go to Arsenal like Benzema or Cavani... just part of the facade that finally came crashing down when Sanchez finally called their bluff... the fact remains that no one wants to win more than Sanchez, including Wenger, and although I don't agree with everything that he has done off the field, I would much rather have Alexis front and center than a manager who has clearly bought into the Kroenke model in large part due to the fact that his enormous ego suggests that only he could accomplish great things without breaking the bank... unfortunately that isn't possible anymore as the game has changed quite dramatically in the last 15 years, which has left a largely complacent and complicit Wenger on the outside looking in... so don't blame those players who demanded more and were left wanting... don't blame those fans who have tried desperately to raise awareness for several years when cracks began to appear... place the blame at the feet of those who were well aware all along of the potential pitfalls of just such a plan but continued to follow it even when it was no longer a financial necessity, like it ever really was...

Safety standards change a lot over the years, so even one that's only a generation old might no longer conform to current safety standards, and high chairs are recalled all the time.

She was reading a New York Times article that was lamenting the current state of breast pumps, and she was appalled at how little they'd changed over the years.

Safety regulations have changed over the years, and you need one that meets all current guidelines.

The Danish Prime Minister Helle Throning - Schmidt got her $ 134 - million rebate, the Netherlands will maintain its 1 billion euro discount through some changes in the arrangements through which it collects EU VAT for Brussels, and David Cameron can go home with the message that the current deal would amount to a budget cut of 34.4 billion Euros over the next seven years.

If there was a change of policy then that change would be highly puzzling, given that the current Labour leader, Jeremy Corbyn, has been an outspoken critic of the House of Lords over many years.

In a study set to take place over the course of a year, the Metropolitan Transportation Authority will look at factors such as ridership, current bus routes and the lines that were cut in 2010 at the height of the agency's financial crisis and will determine if changes can be made to benefit residents in the northeastern part of the borough.

Researchers in California say climate change could spur an increase in global violence by as much as 50 percent over the next forty years if current temperature trends continue.

In their current publication, the Swinburne researchers were able to set an upper limit on the change in Newton's gravitational constant of 1 part in 10 billion per year over the past nine billion years.

Say even if our current change and rate of change is more than 1 sd from the mean over that last million years.

Over the last 40 years, medical studies have led discoveries that could change the current health care system, the food system, and benefit the planet's eco-system.

The evolution of the human diet over the past 10,000 years from a Paleolithic diet to our current modern pattern of intake has resulted in profound changes, not only in our in feeding behavior, but our overall health.

The process has undergone several changes over the years, but things have stabilized to the current practice of six selections from the general volunteer group being supplemented by three picks from a special committee.

And with recent changes in state law, it becomes possible over the next several years to double the number of charter school seats in Boston from the current 5,200.

The report is one of a series that the Brookings team has conducted on the impact of changes in mainstream news media over the past five years, where general reporting on local and statewide education issues has fallen dramatically as print media has struggled in the current economic climate and changes brought on by the internet.

A key improvement of ESAs over school vouchers and tax credits is that funds not used for K - 12 educational purposes can be «saved» or rolled over each year and used for continuing or higher education, thus changing the «use it or lose it» mentality in the current public school funding system.

It has been in the making for over five years, changing from a car built using the same ultra-light, carbon intensive concepts as the current i3 and i8 to one based on CLAR WE.

Over The Last Fourteen Years The Car Has Only Had A Mere 27184 Miles Since New, However Regardless Of This Incredible Current Mileage Reading The Vehicle Has Been Maintained To The Highest Of Standards With Historical Past Honda Main Dealer Service Visits Logged At 6054, 8894, 14706, 18473, 21051 (Timing Belt Change), 25601, 26544, 27090 And 27143 Miles, With The Last Completed By Listers Honda Of Solihull In The May Of 2017.

Until then, expect the new F - 150 to be sold side - by - side with the current truck for a year, as it takes that long for Ford to change over its truck plants from the old product to the new.

We are still amazed that it was 100 years ago when Mitsubishi introduced Japan to the nation's first passenger car: the Model A. Mitsubishi cars have changed a lot over the years to match current style trends and drivers» needs.

For the rest of the Golden State, the current caps will be carried over into next year with no changes whatsoever.

If you wait 10 years before closing your permit, then an inspector will hold you accountable to the most current code, which may have changed over the years since you've built the home or done work on the house.

During this webcast, we covered: • Our proprietary portfolio management process • Personnel changes made in 2015 and the people managing the Fund • Key objectives over the last few years and their impact on current performance • Fund performance YTD • Fund outlook for the 2nd half of 2017 & beyond

If you qualify and add Rate Lock to your policy, Erie will not raise your rates year over year unless you change the drivers or cars on your policy, or you move from your current address.

No immediate change in Fed policy is likely — winding down QE3 over the next few months as announced in December will continue, the Fed funds rate target won't shift from its current zero to 25 basis points and the yield on the ten year Treasury note won't rise by much.

Because these loans are short term, the direct lenders can consider a different group of approval criteria than a bank or credit card might; people's circumstances can change drastically over the course of years or even months, but since payday loans are repaid within weeks, your current employment situation and income are the most important factors and are easily assessed!

Tandy Brands Accessories Inc (NASDAQ: TBAC) presents an interesting conundrum: an undervalued asset situation with a current asset value that has deteriorated significantly over the last year and an activist investor with little track record pushing for change.

If not much has changed over the past year, it might be fine to continue on with your current setup.

The expanded historical series covers 2004 through 2010, and was created to provide historical context to the current series by showing how credit availability has changed over the last 10 years - this includes the housing crisis and ensuing recession.

BLOG POST»S INFORMATION IS CURRENT AS OF THE DATE POST PUBLISHED, PROGRAM HAS CHANGED OVER THE YEARS AND IS SUBJECT TO CHANGE IN THE FUTURE.

Some retirement planners make a fuss over calculating current year's taxes in great detail, but the problem with estimating future taxes is laws frequently change.

These routine visits, typically once or twice per year, allow our doctors to capture a snapshot of your pet's current health and, more importantly, to monitor that health over time so that we can identify and address any changes as they occur.

designed in 1870, the catholic church of santa ana has fine swiss ornaments, underwent several changes over the years, but the current building still remembers the old church

Insurance products change from year to year and over time, so if you want to use the benefits, you have to stay current.

The situation represents a stark contrast with other big productions of the Japanese developer released over the last five years, and perhaps signals a change of cycle in which brands like Monster Hunter grow more popular at a global scale, while other classic properties might not able to recover from their current situation.

Hardcore Pokemaniacs may debate me on this issue, saying tweaks to the metagame like the split of attacks into physical and special categories or the recent Mega-Evolutions changed the way how people play competitively but at its core, Pokémon's battle system has not changed in over 10 years and it needs a good revision to stay current.