Sentences with phrase «change over the cycle»

Not exact matches

There are different cycles of drivers and teams that appeal to the fan base, and that changes over the years.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

See how fast your marketing cycle is over any period of time and whether process changes, training, and new hires are speeding it up.

Additionally, the U.S. economy has dramatically changed over the past several years, with structural factors (largely the result of technological innovation and shifting demographic trends) influencing it in a manner that makes comparisons to past rate hiking cycles less relevant.

The changes occurring in today's high - yield markets, however, indicate that history may not be a perfect guide for investors over the next credit cycle.

Investment managers attempt to outperform the market by predicting market activity, and can add value to portfolios by anticipating market cycles and continuously changing asset allocation over time.

As a rough guide to how prospective returns will change over the completion of the current market cycle, we presently estimate that in order to establish expected 10 - year S&P 500 total returns of 5 % annually, the S&P 500 would have to decline to the mid-1500's.

If market internals improve, we'll take a signal that investors have shifted back to risk - seeking, and that would ease our near - term concerns, but wouldn't materially change our expectations for a market loss on the order of 50 % or more over the completion of the current cycle.

It also doesn't help that the narrative for active management is constantly changing over time depending on where we are in the investment cycle.

Of course, we expect the discipline of investing in alignment with the market's expected return / risk profile, as it changes over the course of the market cycle, to do far better still.

Our analytical team has spent almost its entire collective career specializing in change and in industrial distress, which means we have traded well over a hundred different cycles globally, in many industries.

The central message of our discipline is that valuations are enormously informative about prospects for long - term and full - cycle returns, but that outcomes over shorter segments of the market cycle are driven by changes in the psychological preferences of investors toward speculation or risk - aversion.

Changes in monetary policy might not do much to raise the economy's «long - term» growth potential, but they certainly affect output and employment over the course of the business cycle.

When composted, single serve coffee from compostable pods delivers a conservatively - projected 23 % reduction in the greenhouse gas emissions linked to climate change, compared to conventional drip brewed coffee over its life cycle.

Considered a pilot for other Olympic sports, the plan called for the cycling union to record the results of riders» blood tests over time and track the changes of several key values, including hematocrit and reticulocyte levels.

Both NAFTA and the TPP have been major talking points this presidential cycle, with both major party candidates agreeing changes need to be made while arguing over who is responsible for the current situation.

And that's before accounting for some of the factors that the model doesn't consider: the disagreement in the polls, the unusual nature of Trump's candidacy and the demographic changes it is producing, Clinton's superior turnout operation, the possibility of «shy Trump» voters, the fact that the news cycle is still somewhat fluid headed into the final weekend, the declining response rates to polls, and the substantial number of high - profile polling misses around the world over the past few years.

Over the last four election cycles, New Hampshire's 1st District and Texas» 23rd District have changed hands three times and New York's 24th District has flipped all four.

The Progressive Change Campaign Committee said Wednesday that it raised over $ 1 million this campaign cycle.

Self - serve platforms change this dynamic, giving small and / or local campaigns essentially the same online voter - targeting options that statewide or federal candidates have come to rely on over the past couple of election cycles.

The district has changed hands between the GOP and the Democrats over the last several election cycles, and its current representative, Democrat Dan Maffei, lost his seat once before to a conservative Republican who accused him to being too liberal for this centrist region.

Katko is running for reelection in a congressional district that has changed parties for the last five election cycles, and has expressed concern over Trump's tone and divisive rhetoric, saying Trump will have to earn his vote.

This is notable for a number of reasons, not the least of which is the fact that Katko's district, NY - 24, is fairly closely divided and has changed hands between the major parties over the past several election cycles, which means whoever the incumbent is needs NOT to hew too closely to the party leadership and orthodoxy.

He continued: «over the last two electoral cycles (2010 -2015 and 2015 - 2019), the Commission has deliberately and purposefully embarked upon far - reaching reforms of the electoral system, in terms of changes in voting procedures and enhancing the security features of ballot papers, ballot boxes and result sheets.»

Should he take the non-reactive option and enter into renewed discussions with the County Executive over the additional changes needed in the County Charter, he could target to have voters approve or reject a new Charter in the 2015 election cycle.

By measuring changes in the light reflected from the clouds, they found that the clouds appear to wax and wane in prevalence over a 27 - day cycle.

Cycles that drive changes in the ocean's chemistry and organisms take place over hours, days, seasons, years and even decades — timescales NEPTUNE can track.

Over the course of the menstrual cycle, its composition changes, becoming thicker and rich with blood vessels in preparation for pregnancy, but if the woman does not conceive, the uterus sheds this tissue, causing the woman's period.

Since the rotation axis of Saturn inclines compared to its orbital plane around the Sun, the ring opening angle to the Sun changes over a 15 - year cycle.

And he points out that using layer thickness to measure Milankovitch cycles requires a risky assumption: that the rate of sediment accumulation, which built these layers, did not change much over 32 million years.

«We can use the inclusions to date different parts of an individual diamond, and that allows us to potentially look at how the processes that formed diamonds may have changed over time and how this may be related to the changing carbon cycle on Earth.»

A new study of the global cycle of these uranium isotopes brings additional perspectives to the debate on how Earth has changed over billions of years as revealed in a recently published study in the journal Nature.

The change in dentition suggests that monkeys took over a niche that apes previously occupied, though whether that was a dietary niche or had more to do with primate life cycle remains to be figured out, she said.

«What we didn't realize until now is that over the past decade, changes in the global water cycle more than offset the losses that occurred from groundwater pumping, causing the land to act like a sponge.

We created a thin - film device that operates on the same principle but with two types of solid redox materials that produce a change in the potential difference in the cell over a heating and cooling cycle,» firstauthor Takayuki?Shibata says.

The Tropical Pacific climate response to the changing forcing over the last glacial cycle William Roberts, Paul Valdes

Ecological niche models supported inference of drastic changes in the extent of its breeding range over the last glacial — interglacial cycle.

For carbon perturbations that take place over shorter timescales, the pace of carbon - cycle changes will not matter; instead, the size or magnitude of the change will determine the likelihood of an extinction event.

They then infer a higher temperature sensitivity to changes in radiance over this cycle and conclude that maybe 0.1 K temperature increase would be possible due to the variation in solar radiance, or about 30 % (if you push it) of the total temperature anomaly over this period.

They also looked at changes in Martian gravity — which is about one - third that of Earth's gravity — over 11 years (the same as the sun's cycle of activity).

We recently extended this record to approximately 120,000 years BP in order to track vegetation change over a full glacial cycle at millennial to orbital timescales.

For example, 2005 is near solar minimum in the 11 year cycle, and radiance now is about 1 - 2 W / m ^ 2 less than a few years ago, which means Pluto and Mars are getting LESS solar radiance on the time scale of the atmosphere and polar cap changes, EVEN IF the radiance averaged over the whole cycle was higher.

In a paper published in Science Advances, he proposes that mass extinction occurs if one of two thresholds are crossed: For changes in the carbon cycle that occur over long timescales, extinctions will follow if those changes occur at rates faster than global ecosystems can adapt.

This is based on the fact that, while the change in total energy is only 0.1 % during a sun cycle, the change in UV is over 10 %, which has its largest effect in the stratosphere.

Re 92 and 105: First I just want to reitterate more generally what 105 said — Milankovitch cycles have had climate signals, in ice ages or otherwise, — well probably ever since the Moon formed, although the signal from times past will not always reach us, but I've read of evidence of Milankovitch precession cycle forcing of monsoons in lakes in Pangea (PS over geologic time the periods of some of the Milankovitch cycles have changed as the Moon recedes from the Earth due to tides).

We want to watch the changes in the structure of its circumstellar envelope and its magnetic field over an entire cycle,» Diamond said.

These ocean winds, in turn, are affected by variations in natural cycles that manifest in changes at the surface of the ocean and immediately over it.

A new study shows that nitrogen - feeding organisms exist all over the deep ocean, and not just in large oxygen - depleted «dead zones,» changing the way we think about the delicate nitrogen cycle.

Astronomers now know that these regular brightness variations are caused by Betelgeuse's rhythmic change in size over an approximately six - year cycle.

By comparing findings of the current period of minimum activity with those of previous cycles, scientists can paint a picture of the changes in the sun over a span of decades, and sometimes centuries.