«Knowing that immune cytokines can
change pigment production in melanocytes, while also knowing that chronic inflammation has the potential to increase the number of melanocytes, has clear implications for the design of future therapies to address a set of common skin disorders,» says Dr. Krueger, director of Milstein Research Program and D. Martin Carter Professor in Clinical Investigation.
Not exact matches
Melanocytes respond by altering gene transcription, and these
changes in gene expression profiles result in easily quantifiable phenotypes such as modified
pigment production (a hallmark of melanocyte differentiation state) and
changes in morphological cell properties.
The cells produce the
pigment melanin, which is chemically linked to adrenaline (also known as epinephrine), the «fight or flight» hormone whose
production is affected by
changes in the animals» fear responses.