Sentences with phrase «change the activity of»

Chemical modifications to DNA that change the activity of genes without changing the genes» information differ between homosexual and heterosexual men, researchers from UCLA David Geffen School of Medicine have discovered.

«The finding that certain cell signaling lipids change the activity of an oncogenic Ras protein, suggests that we might be able to interfere with tumor progression by inhibiting the enzymes which make the specific cell signaling lipid in cells,» Buck said.

The differences between male and female iPS cells are most pronounced for one of the key processes in the field of epigenetics: DNA methylation, a modification that changes the activity of a DNA segment without changing its sequence.

Pyles also indicated that this model «will provide the opportunity to study the way that these mixed species bacterial communities change the activity of vaginal applicants including over-the-counter products like douches and prescription medications and contraceptives.

When this protein is damaged or missing, it changes the activity of multiple genes and causes Rett syndrome, a disorder marked by developmental delays, seizures and autism - like behaviors.

There it changes the activity of genes by adding or removing methyl groups.

Noninvasive brain stimulation is having its heyday, as scientists and hobbyists alike look for ways to change the activity of neurons without cutting into the brain and implanting electrodes.

In the new research, published in Neuron, the scientists found that the apoE4 protein changes the activity of neurons in the hippocampus — an important memory center in the brain that is severely affected by Alzheimer's disease.

They also support the existence of four related subtypes based on the patterns of DNA methylation — a chemical reaction in which a small molecule called a methyl group is added to DNA, changing the activity of individual genes.

One study found that exposure to chronic stress actually changes the activity of the genes of immune cells — making them more likely to attack the body's own tissue and trigger an autoimmune response.

This is also observed in the changing activity of the Sun.

Not exact matches

«This is a breakthrough technology that really changes what's possible in terms of sensing and stimulating nerve activity, especially nerves deep inside the body,» Weber says.

Goal - setting actually changes the chemistry of our brains, and studies have shown that that activity can increase motivation and boost achievement levels by approximately 30 percent.

Such factors include, among others, general business, economic, competitive, political and social uncertainties; the actual results of current and future exploration activities; the actual results of reclamation activities; conclusions of economic evaluations; meeting various expected cost estimates; changes in project parameters and / or economic assessments as plans continue to be refined; future prices of metals; possible variations of mineral grade or recovery rates; the risk that actual costs may exceed estimated costs; failure of plant, equipment or processes to operate as anticipated; accidents, labour disputes and other risks of the mining industry; political instability; delays in obtaining governmental approvals or financing or in the completion of development or construction activities, as well as those factors discussed in the section entitled «Risk Factors» in the Company's Annual Information Form for the year ended December 31, 2017 dated March 15, 2018.

As a CEO of a sales technology company, I can't help but think of some of the most notorious sales movies that showcase not only the effectiveness of phone - based selling, but also remind us that managing to a proven standard of selling activity hasn't changed.

Although the DDR was not developed specifically to promote physical activity, it has changed exercise attitudes and behavior of children and youth using principles of persuasive technology.

«All of these activities will be like mini-vacations and help refresh you and completely change the channel.

Since these four factors are unlikely to change anytime soon, those looking for a rebound in start - up activity have a long wait ahead of them.

Almost one - fifth of the time spent in US workplaces involves performing physical activities or operating machinery in a predictable environment — that is, specific actions in familiar settings where changes are relatively easy to anticipate.

We refer to the net amount of cash generated from operating activities and investing activities (excluding changes in restricted cash and acquisitions) from continuing operations as «free cash flow».

If you suspect your credit rating could be changed as a result of account activity you didn't initiate or know about, Hamrick recommends checking with the three major credit bureaus: Equifax, TransUnion and Experian.

He points to the fact that Smith is currently investigating the activities of federal climate scientists whose research last year undermined claims by Climate Change skeptics that global warming was going through a «hiatus».

ORIGINAL REQUEST: Account / wallet / vault registration records for each account / wallet / vault owned or controlled by the user during the period stated above including, but not limited to, complete user profile, history of changes to user profile from account inception, complete user preferences, complete user security settings and history (including confirmed devices and account activity), complete user payment methods, and any other information related to the funding sources for the account / wallet / vault, regardless of date.

This means the current activity is part of a trend change and not just a short time rally.

Actual results and the timing of events could differ materially from those anticipated in the forward - looking statements due to these risks and uncertainties as well as other factors, which include, without limitation: the uncertain timing of, and risks relating to, the executive search process; risks related to the potential failure of eptinezumab to demonstrate safety and efficacy in clinical testing; Alder's ability to conduct clinical trials and studies of eptinezumab sufficient to achieve a positive completion; the availability of data at the expected times; the clinical, therapeutic and commercial value of eptinezumab; risks and uncertainties related to regulatory application, review and approval processes and Alder's compliance with applicable legal and regulatory requirements; risks and uncertainties relating to the manufacture of eptinezumab; Alder's ability to obtain and protect intellectual property rights, and operate without infringing on the intellectual property rights of others; the uncertain timing and level of expenses associated with Alder's development and commercialization activities; the sufficiency of Alder's capital and other resources; market competition; changes in economic and business conditions; and other factors discussed under the caption «Risk Factors» in Alder's Annual Report on Form 10 - K for the fiscal year ended December 31, 2017, which was filed with the Securities and Exchange Commission (SEC) on February 26, 2018, and is available on the SEC's website at www.sec.gov.

I had to change my perspective: My health and fitness is an all day activity, not just a «session» or a period of time.

Such risks, uncertainties and other factors include, without limitation: (1) the effect of economic conditions in the industries and markets in which United Technologies and Rockwell Collins operate in the U.S. and globally and any changes therein, including financial market conditions, fluctuations in commodity prices, interest rates and foreign currency exchange rates, levels of end market demand in construction and in both the commercial and defense segments of the aerospace industry, levels of air travel, financial condition of commercial airlines, the impact of weather conditions and natural disasters and the financial condition of our customers and suppliers; (2) challenges in the development, production, delivery, support, performance and realization of the anticipated benefits of advanced technologies and new products and services; (3) the scope, nature, impact or timing of acquisition and divestiture or restructuring activity, including the pending acquisition of Rockwell Collins, including among other things integration of acquired businesses into United Technologies» existing businesses and realization of synergies and opportunities for growth and innovation; (4) future timing and levels of indebtedness, including indebtedness expected to be incurred by United Technologies in connection with the pending Rockwell Collins acquisition, and capital spending and research and development spending, including in connection with the pending Rockwell Collins acquisition; (5) future availability of credit and factors that may affect such availability, including credit market conditions and our capital structure; (6) the timing and scope of future repurchases of United Technologies» common stock, which may be suspended at any time due to various factors, including market conditions and the level of other investing activities and uses of cash, including in connection with the proposed acquisition of Rockwell; (7) delays and disruption in delivery of materials and services from suppliers; (8) company and customer - directed cost reduction efforts and restructuring costs and savings and other consequences thereof; (9) new business and investment opportunities; (10) our ability to realize the intended benefits of organizational changes; (11) the anticipated benefits of diversification and balance of operations across product lines, regions and industries; (12) the outcome of legal proceedings, investigations and other contingencies; (13) pension plan assumptions and future contributions; (14) the impact of the negotiation of collective bargaining agreements and labor disputes; (15) the effect of changes in political conditions in the U.S. and other countries in which United Technologies and Rockwell Collins operate, including the effect of changes in U.S. trade policies or the U.K.'s pending withdrawal from the EU, on general market conditions, global trade policies and currency exchange rates in the near term and beyond; (16) the effect of changes in tax (including U.S. tax reform enacted on December 22, 2017, which is commonly referred to as the Tax Cuts and Jobs Act of 2017), environmental, regulatory (including among other things import / export) and other laws and regulations in the U.S. and other countries in which United Technologies and Rockwell Collins operate; (17) the ability of United Technologies and Rockwell Collins to receive the required regulatory approvals (and the risk that such approvals may result in the imposition of conditions that could adversely affect the combined company or the expected benefits of the merger) and to satisfy the other conditions to the closing of the pending acquisition on a timely basis or at all; (18) the occurrence of events that may give rise to a right of one or both of United Technologies or Rockwell Collins to terminate the merger agreement, including in circumstances that might require Rockwell Collins to pay a termination fee of $ 695 million to United Technologies or $ 50 million of expense reimbursement; (19) negative effects of the announcement or the completion of the merger on the market price of United Technologies» and / or Rockwell Collins» common stock and / or on their respective financial performance; (20) risks related to Rockwell Collins and United Technologies being restricted in their operation of their businesses while the merger agreement is in effect; (21) risks relating to the value of the United Technologies» shares to be issued in connection with the pending Rockwell acquisition, significant merger costs and / or unknown liabilities; (22) risks associated with third party contracts containing consent and / or other provisions that may be triggered by the Rockwell merger agreement; (23) risks associated with merger - related litigation or appraisal proceedings; and (24) the ability of United Technologies and Rockwell Collins, or the combined company, to retain and hire key personnel.

That's an apt description of Fluid Life, which in the past eight years has changed its core offering (moving from increasingly commoditized testing services to include a suite of consulting activities), expanded its Brampton, Ont.

* Eyes on Fed's view of economy, inflation outlook (Updates with early U.S. markets» activity, changes dateline, previous LONDON)

Start making gradual changes by reaching out to friends and family and make a list of activities you'd like to schedule.

«I changed our business and a key part of that was outsourcing many of the activities that Xirrus had done internally, such as manufacturing,» he said.

It is contemplated that a user that may be nervous or engaging in speaking falsehoods may exhibit different galvanic skin response» — a change in the electrical resistance of the skin that is a physiochemical response to increased sympathetic nervous system activity — «than a more confident, truth telling individual.»

LONDON / FRANKFURT / MILAN, May 2 (Reuters)- U.S. hedge fund Elliott is stepping up its activities in Europe, a Reuters review of data shows, as it sees more opportunities to unlock value for shareholders by pushing through management changes, company break - ups and merger deals.

Social media measurement can be overwhelming, and half the challenge is simply keeping up with the content that is being changed by the millions of living, breathing users and discerning what has value and what doesn't, while at the same time keeping up with the social media platforms that are developing at an equally rapid rate with their user activity.

This ever - changing construct represents a way of communicating for people who like to inform each other about their daily activities and share common points of interest, according to Wikipedia authors Lambert M. Surhone, Mariam T. Tennoe, and Susan F. Henssonow.

LONDON / FRANKFURT / MILAN, May 2 - U.S. hedge fund Elliott is stepping up its activities in Europe, a Reuters review of data shows, as it sees more opportunities to unlock value for shareholders by pushing through management changes, company break - ups and merger deals.

(Updates prices, market activity and comments to U.S. market open, new byline, changes dateline, previous LONDON) NEW YORK, May 3 (Reuters)- The U.S. dollar was little changed in choppy trading on Thursday as investors took profits from a rally that sent the greenback to its highest levels of the year and awaited Fridays payrolls data for April.

Zuckerberg's plan is to investigate all apps that had access to large amounts of information before Facebook changed its data sharing policies in 2014 and to conduct an audit of any app that shows suspicious activity.

Such activities can help change a naysayer mindset by showing staffers the value of working together for a common cause.

In this case, much of Virgin's involvement involves fundraising and raising awareness, which engages our staff in all manner of activities, from joining sponsored swims to collecting passengers» spare change on flights.

At the same time, the rate of self - employment has barely budged so it seems clear that much of this big shift has been tax - motivated rather than reflecting changes in actual economic activity.

Often a quick change of scenery or light physical activity provides a useful reset to the creative system.

Secretary Perry, for instance, who presided over the greatest expansion of wind capacity in the country during his 14 years as governor of Texas, acknowledged in his confirmation hearing that climate change is real, and that «man - made activity» is at least partly to blame.

That ubiquity, coupled with its extreme sensitivity to changing demand, has led many to regard is as a leading indicator of activity in goods - producing industries.

Still, farm retailer objectives must remain the same regardless of these challenges or merger activity: gain efficiencies and remain relevant in the face of a changing industry.

«M&A dialogue remains robust despite concerns about the potential impact of changes in America's trade and national security policies on deal activity,» said Stephen Arcano, head of M&A at Skadden.

Perry has questioned the scientific consensus that carbon dioxide emissions from human activity are the primary driver of climate change.

Trump's stance on the environment contradicts thousands of scientists and decades of research, which has linked many observable changes in climate, including rising air and ocean temperatures, shrinking glaciers, and widespread melting of snow and ice, to an increase in greenhouse gas emissions from human activities.

«Conveniently, when CHX's preferred market participants engage in the activity of updating prices of SPY due to changes in the price of S&P 500 futures using sophisticated pricing algorithms, it is generally beneficial, whereas when another market participant does the same thing, it «diminishes displayed liquidity and impairs price discovery.»»

While many of the VR and AR technologies that support this kind of activity are still nascent, that's changing quickly.