Sentences with phrase «changes developed over the years»

And an abundance of guideline changes developed over the years to accommodate the new procedures.

Not exact matches

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

Research on these pastures also shows that the management practices developed over the past 80 years has resulted in higher levels of biodiversity and soil quality than in comparable privately - owned lands - factors that may become increasingly important with the advent of climate change.

With over 30 years of wide - ranging experience in the industry, Morgiewicz is known for leading change effectively, building and developing execution teams, developing talent, and providing superior customer service.

The Can Makers, a trade body representing the UK companies responsible for the manufacture of beverage cans, examines how the drinks can has changed and developed over the years

That same year, Worth introduced the Titanium Ti51 bat — which, rumor has it, was developed five years earlier but kept under lock - and - key due to fears over how it would surely change the game; Easton's release forced Worth's hand — which included a 0.051 - inch thick seamless titanium tube with an aluminum knob welded to the handle.

The tactical side of football is always developing and changing to some extent and Arsene Wenger has himself earned a well deserved reputation for the way that Arsenal have played the game since he took over as our manager almost 20 years ago.

If it hasn't changed dramatically over the past ten years, it probably isn't keeping pace with other clubs who have developed their academy with new ways of thinking.

They do develop, but over such a long career, nearly 37 years since it began in 1976, it is very difficult to pinpoint changes.

«We hope these findings will help foster discussion both about how changes in pediatric athletic participation over the past 20 years may be impacting injury rates and how we can best develop youth injury prevention programs and athletic participation guidelines,» said Marc A. Tompkins, MD, an assistant professor of orthopaedic surgery at the University of Minnesota.

Over the course of the year children experience the changing seasons and begin to develop a sensitivity to the subtle transformations in the landscapes around them.

And of course there's that stuff about how milk changes over the course of nursing to meet the needs of a developing child (milk from women who have been nursing longer than one year has a substantially higher fat content — which is exactly what they need).

Over the years, they have developed technology such as the white hot technology where the spoon turns white when the food is hot that has changed feeding babies by making it safer.

Instead of focusing on what an individual politician says, we can assess millions of speeches over hundreds of years to show how political language changes over time, or how a specific kind of contentious issue develops.

The sentencing framework has developed in an ad hoc fashion recently, with over 20 Acts of Parliament changing sentencing in the past 10 years.

«That this House commends the Speaker on the action he has taken over the past year to reassert the principle that Ministers ought to make statements to the House before they are made elsewhere; notes that paragraph 9.1 of the Ministerial Code says that when Parliament is in session, the most important announcements of Government policy should be made in the first instance in Parliament; believes that compliance with this principle is essential for backbenchers to be able to represent the interests of their constituents and hold the Government to account; and invites the Procedure Committee to consider how the rules of the House could be better used or, if necessary, changed to ensure compliance with this principle and to develop a protocol for the release of information.»

Yet over the years, he has developed a reputation among advocates for not caring much for mass transit, a reputation he now seems intent on changing.

First - line TB tests and treatments in the developing world have not changed for over 30 years.

Seeing the sharp declines in parts of the ocean I have come to know and love reminds me that as we look into new ways to protect our planet from climate change, we need to look again at the natural machinery that already works, that developed over four and a half billion years, and do everything we can to restore its functions.

Using this input, a sophisticated computer model developed at NASA's Goddard Space Flight Center, Greenbelt, Maryland, was used to determine which areas receive direct sunlight, how much solar radiation reaches the surface, and how the conditions change over the course of a year on Ceres.

A number of theories have been developed over the years to explain more recent extinctions such as those at the end of the last ice age, including human hunting, climate change, disease, and even a cosmic impact such as an asteroid or comet.

In addition to problems created by sudden climate changes over a few decades or even a few years, the committee points to abruptly developing problems created by a steadily changing climate.

By tuning the model to replicate population data, such as the number of people at risk for developing TB and the fraction of TB patients who have drug resistance, the model can predict changes in the TB disease burden — or number of cases — over many years.

That work has yet to be published, but Federoff says the changes in genes over the five years of the study are even more powerful than the metabolites at predicting who will develop dementia.

The brain develops over the course of the prenatal period, but it will continue to go through more changes during the early years of childhood

Also, because HD takes many years or decades to develop, differences seen in HD patients may seem large at the baseline but actually be due to very slow changes that take place over a long time.

Evolution is typically thought of as a process that occurs over hundreds or thousands of years, but this doesn't mean that we can not observe genetic changes as they develop.

Just as an alcoholic does not regain full vigor and health by stopping the flow of bourbon, but must address nutritional deficiencies, liver problems, as well as the social disruption of alcoholism, so a former wheat - and grain - eater must undo all the adverse effects that developed over years of consuming foods changed by agribusiness.

A wellness authority and supportive mentor, for over 12 years Shelby has helped boat loads of clients lose weight, develop skill sets to better manage their daily nutrition and empowers individuals to make lasting changes in their eating behaviors and lifestyle.

Take the mobile phone as an example, we can see the rise in its universal and the way it has developed over the years has led to some drastic changes in the way we lead our lives.

Challenges At the same time as acknowledging the strong case for focusing teaching on big ideas, it is important to recognise that some developments over recent years have created challenges to the changes that are needed for students to have the chance to develop understanding.

2016 has been full of changes and opportunities that schools have started to embrace and tackle, and I'm looking forward to seeing how this continues to develop over the next year as well as the new prospects in store for 2017

These worksheets look briefly at India in economics, environmental, global, local, national and social terms and the students discuss how they think India may develop and change over the next ten years

THREE fantastic units of work that focus on basic literacy skills - listening, visuals, technology (1) SOUNDS & MUSIC is about recognising everyday sounds, listening mindfully, exploring music and songs (2) FILMS & DOCUMENTARIES focuses on viewing a variety of visual tools through films and documentaries and linking ideas (3) TECHNOLOGY & APPS helps students develop awareness around apps that help them explore ideas and themes and how technology has changed over years.

It will attract more candidates if they can see this as a true profession where they will be supported to develop and grow over many years, rather than a version of the Peace Corps that puts them on the urban front - line to champion change all by themselves.

It's possible to develop a pretty good picture of how schools and districts are doing using samples of students and samples of test items — that's what the National Assessment of Educational Progress has been relying on for decades — and there's nothing magical about a school year that makes it the inevitable time period over which to assess changes in school and district performance.

Ken Spero, CEO of «ELS» and simulations creator, has spent over 25 years developing and incorporating computer - based simulations change management and leadership and organization development interventions.

Other activities in which teacher candidates engaged have engaged in my courses are attending webinars hosted by the National Council of Geography Education on integrating online maps into pedagogical practice, using Google Earth ™ to create flyovers and virtual fieldtrips, retrieving and analyzing remotely sensed imagery of our town and university to visualize how these places had changed and developed over the years, using various functions in Google Maps ™, and reviewing school demographic and testing data in preparation for instructional planning.

We were able to lead with an equity lens and work with our boards to make some lasting changes thanks to the credibility we developed over the years.

During CTL's recent 20th Anniversary Education Forum and Celebration held at the Muhammad Ali Center in downtown Louisville, table groups of educators and policy makers developed actionable steps to address one of three forum themes — equity, innovation and systems change — with the aim of inventing a new educational future over the next 20 years.

Over the years educator activists who have worked with NYCoRE to struggle for social change have developed resources for teachers, parents, and youth.

«When I wrote the second edition of The Differentiated Classroom, I had the opportunity to reflect on the many changes in education over the past 15 years and develop new ways to make differentiated instruction successful in today's schools,» said Tomlinson.

In the bill that allowed towns to «phase - in» the state's new teacher evaluation system over the next two years, rather than forcing all of the changes this year, the legislature added two significant restrictions to a town's right to develop their own system.

Though the design has continued to change over the last 50 years, the fundamentals are still in place: rear - mounted flat - 6 engine and a precision chassis developed with handling in mind.

Over the past few years, the division hasn't changed its sheet metal much but has concentrated instead on developing a world - class array of engines and transmissions.

Over the years, he took on employees and developed a specialty in crafting boardroom tables, but he rarely noticed how these changes affected his company.

Over two thousand years, the process of electing a new Pope has been refined and developed, most recently changing in 1970 when Pope Paul VI limited the age of the Cardinals involved in the conclave to 80 years old.

Over two thousand years, the process of electing a new Pope has been refined and developed, most recently changing in 1970 when Pope Paul VI limited the age of the Cardinals involved in...

I have developed over 150 author and publisher websites in the last 20 years, and although a lot has changed when it comes to developing websites, some things remain fundamental.

«I'm a divorced dad and I came to realize that the only way to change the enabling relationship I had developed over the years with my kids was to take personal responsibility for changing it,» says Carson.