Sentences with phrase «changes in cell shape»

Methods: The team profiled lipids using analytical chemistry techniques and monitored changes in cell shape using capabilities in the Quiet Wing at EMSL, a Department of Energy national scientific user facility located at PNNL.

In future, Gilmour and colleagues would like to understand the interplay between the ability — or decision — to stop and signals that they previously found drive cells to move forward, and how both are influenced by changes in cell shape.

Those analyses have long relied on qualitative changes in cell shape to track physiological shifts.

Forced expression of this SMN1 variant in cultured non-neuronal cells induces the formation of neurite - like extensions, a change in cell shape reminiscent of that occurring when motor neurons send out axons to their muscle targets.

Not exact matches

It occurs when some of the red blood cells change into a «sickle» shape and cause a buildup of red blood cells in small blood vessels.

«Our analysis revealed that the differences between tame and aggressive foxes may lie in cells in the anterior pituitary gland, which can change their shapes to communicate with one another about when it's time to release stress hormones,» Hekman said.

But the London researchers have shown a few small changes in the shape of a surface protein were all it took to enable the bird version of Spanish flu to bind onto human cells.

Prestin changes shape when exposed to high - frequency sound, and this in turn deforms the fine hair cells, setting off an electrical impulse to the brain.

Molecules in these cells change shape when light hits them.

Her most recent paper — this one published in PNAS, the official journal of theNational Academy of Sciences — explains a totally new way that viruses operate in building particles and how viruses can change shapes to interact with their host cells.

He and colleagues have determined what gives cholera bacteria their curved shape and whether it matters (a polymer protein, and it does matter; the curve makes it easier for cholera to cause disease), how different wavelengths of light affect movement of photosynthetic bacteria (red and green wavelengths encourage movement; blue light stops the microbes in their tracks), how bacteria coordinate cell division machinery and how photosynthetic bacteria's growth changes in light and dark.

These atypical AMPA receptors were missing a key subunit, called GluA2, that caused a change in shape and allowed calcium ions to enter the cell.

To determine if Sup35 could change shape on its own or if it needed help from other molecules in the cell, the team studied the purified protein in the test tube.

The binding triggers the β2AR to change shape and release a «G» protein, which in cells binds to the inside end of the receptor.

In fact, there's reason to believe that all of the properties of cell biology that made complex life possible in the next geologic era were put in place here: cytoskeletons that allow eukaryotic cells to change shape, and cell polarity that allows cells to send a molecular message to one side of the cell but not the other, and to interact with nearby cellIn fact, there's reason to believe that all of the properties of cell biology that made complex life possible in the next geologic era were put in place here: cytoskeletons that allow eukaryotic cells to change shape, and cell polarity that allows cells to send a molecular message to one side of the cell but not the other, and to interact with nearby cellin the next geologic era were put in place here: cytoskeletons that allow eukaryotic cells to change shape, and cell polarity that allows cells to send a molecular message to one side of the cell but not the other, and to interact with nearby cellin place here: cytoskeletons that allow eukaryotic cells to change shape, and cell polarity that allows cells to send a molecular message to one side of the cell but not the other, and to interact with nearby cells.

But the cells also changed shape and other properties in the absence of the protein in ways that reduced the likelihood that they would travel away from the tumor — a sign that myoferlin not only changes genes in cancer cells, but also alters the cells» mechanical properties.

The research suggests that reducing production of the protein, called myoferlin, affects cancer cells in two primary ways: by changing the activation of many genes involved in metastasis in favor of normal cell behavior, and by altering mechanical properties of cancer cells — including their shape and ability to invade — so they are more likely to remain nested together rather than breaking away to travel to other tissues.

The tool will enable better phenotyping of cell shapes and also understanding of how cell shapes change in relation to others, and over time.

For example, the hippocampal place cell representation of location was previously found to respond continuously to changes in environmental shape alone.

Proteins inside a cell are in constant motion, changing shape continuously in order to carry out their functions.

For instance, a cell tuned to an axis where nose width and eye size changed wouldn't respond to changes in lip shape.

So over time, changes in the cytoskeleton form the shape and behavior of cells and, ultimately, the structure and function of the organism as a whole.

The research team found that this non-coding RNA fragment maintains healthy cells through two mechanisms: Firstly by regulating the levels of DIRAS3, one of its neigboring genes that is involved in cell replication; secondly by suppressing a network of genes that prepare cells to change their shape and prepare for metastasis.

Aging in intestinal stem cells leads to changes in villi, the finger - shaped protuberances that line the small intestine and absorb nutrients, and crypts, the valleys between villi where the intestinal stem cells live.

Photoswitches — chemicals that change shape when hit with light - are then attached to the ion channels to make them open in response to light, activating the retinal cells and restoring light sensitivity.

When two copies of the altered hemoglobin gene are present, they cause the shape of the hemoglobin to change so much that the «sickled» blood cells don't flow freely in the blood vessels, causing excruciating pain.

Additional micro-patterning of the substrate changes the cytoskeleton in the cell and the shape of the nucleus, which cause the genes in the cell to change.

In agreement with predictions from these models, we show that minimal changes in the shape of the environment in which rats are exploring can substantially alter correlated activity patterns among place - modulated granule cells in the dentate gyruIn agreement with predictions from these models, we show that minimal changes in the shape of the environment in which rats are exploring can substantially alter correlated activity patterns among place - modulated granule cells in the dentate gyruin the shape of the environment in which rats are exploring can substantially alter correlated activity patterns among place - modulated granule cells in the dentate gyruin which rats are exploring can substantially alter correlated activity patterns among place - modulated granule cells in the dentate gyruin the dentate gyrus.

Actin also enables the cone - shaped tip of the cell to change in a fixed pattern, generating a highly specialized shape that is effective in insect defense.

Lin observed that this change in nucleus shape is similar to what occurs during cell division and hypothesized that there may be similar underlying mechanisms behind cell division and regeneration.

In the second phase, the cell's nucleus, containing its DNA, changes shape.

Following this, cells undergo shape changes and organise around a central lumen, with their apical (top) surfaces facing the lumen, the basal (bottom) surfaces interacting with the underlying tissue and the lateral (side) surfaces in close contact with the neighbouring cells.

One reason that fast - relaxing microenvironments promote more osteogenesis and form bone is that cells inside these matrices can mechanically remodel the matrix and more easily change shape, said Ovijit Chaudhuri, former postdoctoral fellow in the Mooney lab and co-first author.

In dendrites and axons these rapid structural and functional changes occur concurrently — their length, size, shape, and number change to suit the needs of neuronal cell body communication.

Voltage - dependent potassium ion (K +) channels (Kv channels) conduct K + ions across the cell membrane in response to changes in the membrane voltage, thereby regulating neuronal excitability by modulating the shape and frequency of action potentials.

«Within 3 weeks after expression of the NeuroD1 protein, we saw in the microscope that human glial cells were reinventing themselves: they changed their shape from flat sheet - like glial cells into normal - looking neurons with axon and dendritic branches,» Chen said.

In a study published in Molecular Cell this month, Alexei V. Tulin, PhD, Associate Professor at Fox Chase Cancer Center, and colleagues reported that chemical modification of one type of histone — called H2Av — leads to substantial changes in nucleosome shapIn a study published in Molecular Cell this month, Alexei V. Tulin, PhD, Associate Professor at Fox Chase Cancer Center, and colleagues reported that chemical modification of one type of histone — called H2Av — leads to substantial changes in nucleosome shapin Molecular Cell this month, Alexei V. Tulin, PhD, Associate Professor at Fox Chase Cancer Center, and colleagues reported that chemical modification of one type of histone — called H2Av — leads to substantial changes in nucleosome shapin nucleosome shape.

Rod and cone cells in the human retina contain proteins called opsins that change shape when light strikes them.

This communication triggers a change in the scaffolding of the cell perimeter — altering from a fixed shape, attached to an organ, to a less stable one, moving freely around the body.

As cells jammed or unjammed, cell shapes changed in a systematic manner in both systems, thus suggesting a common physical basis.

The cells that group together and stop to form the future organ also change shape, going from flat, crawling cells to upright, tear - shaped cells that come together like cloves in a bulb of garlic.

This relationship is perhaps most striking during the first stages of embryogenesis, when cells change in size and shape several fold in the absence of growth.

«For example, we would change the shape of the eyes in a cartoon face and find that some cells would be sensitive to this change.

Kyoto University cell biologists wanted to find out if «flipping» enzymes belonging to the P4 - ATPase family were involved in inducing cell membranes to change shape.

In the new study, the virus appeared to change shape as it locked on to the cell.

These changes in chromosome shape then affect how the cell divides and how genetic information is passed on to new cells.

To a small but growing number of physicists, however, the shape - shifting and behavior changes in cancer cells evoke not an errant genetic program but a phase transition.

In the light of a review detailing the role of these genes in the cell shape changes leading to invagination, and of recent findings showing the expression of twist as mechanically sensitive, we suggest that the expression of twist in the mesoderm could alternatively be maintained by mechanical strains developed during mesoderm invaginatioIn the light of a review detailing the role of these genes in the cell shape changes leading to invagination, and of recent findings showing the expression of twist as mechanically sensitive, we suggest that the expression of twist in the mesoderm could alternatively be maintained by mechanical strains developed during mesoderm invaginatioin the cell shape changes leading to invagination, and of recent findings showing the expression of twist as mechanically sensitive, we suggest that the expression of twist in the mesoderm could alternatively be maintained by mechanical strains developed during mesoderm invaginatioin the mesoderm could alternatively be maintained by mechanical strains developed during mesoderm invagination.

But they both have a very unusual ability to change shape and to spread this change in shape from cell to cell.

«We've shown that a change in the shape of a protein can perpetuate itself and be passed to other cells, without a change in DNA or RNA.