Sentences with phrase «changes in cells of»

It also causes «changes in cells of the skin, fibrous tissue and blood vessels leading to premature skin aging... Another long - term effect is an inflammatory reaction of the eye.»

The current research findings build upon recent discoveries including novel identification of key genetic changes in cells of the immune system.

Not exact matches

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

In an earnings call later that summer, Peter Rive, who was then SolarCity's CTO, explained the merits of the changes to shareholders: «We don't want to rush to actually initiate some of the equipment installation for the cell line and then have that be a regretful layout only months later.»

This provides a game changing advantage in regenerative medicine that otherwise relied on the concept of stem cells.

Whether it is changing text books to teach religion as a «science,» making laws that prohibit stem - cell research which would without question help those in need, to stopping of any kind of gay rights, trying to put religion (christianity) into schools, a woman's right to choose, etc, etc...

The evolutionary, ecological perspective insists that we are, in the most profound way, «not our own»: we belong, from the cells of our bodies to the finest creations of our minds, to the intricate, ever - changing cosmos.

That balance has changed considerably in the past few years, as alternative avenues of stem - cell science have opened up and it increasingly seems like whatever therapeutic potential such cells may someday have could be explored and achieved without the destruction of embryos.

Thus, the transition from instinct to reason results in the radical transformation of the animal into man; matter as it evolves toward the cell becomes radically transformed into living matter; and vegetative life becomes qualitatively changed into conscious life.

At Key Stage 3 (age 11 to 13 +, Years 7 to 9) schools have to teach: that fertilisation in humans and flowering plants is the fusion of a male and a female cell; about the physical and emotional changes that take place during adolescence; about the human reproductive system, including the menstrual cycle and fertilization; how the foetus develops in the uterus, including the role of the placenta.

... yeah suzy and others... I just happen to realize that when monkey devolving didn't quite work out on paper it all changed to single cells and from the slime off of the worlds garbage can and so on... I just happen to know more than you think... In another ten or twenty years the science books will all have a new teaching... the Bible has been around and hasn't changed one word in over two thousnad yearsIn another ten or twenty years the science books will all have a new teaching... the Bible has been around and hasn't changed one word in over two thousnad yearsin over two thousnad years..

What model exists to explain what would have been the greatest quantum change in the history of the universe, namely the first cell?

The cell theory of organisms was a change in principle, not merely in degree, compared to all ancient thought.

(Cf. the phenomenon of the «runners» at first connected with the mother plant and then separated from it; the fluid transition between various plants and animals which appear to be one; the germ - cell inside and outside the parent organism, etc.) Living forms which present what are apparently very great differences in space and time can ontologically have the same morphological principle, so that enormous differences of external form can derive from the material substratum and chance patterns of circumstance without change of substantial form (caterpillar - chrysalis butterfly).

In the June 2010 issue of Nature Medicine, in an interview with theBoston - based researcher, Daley tells how he further changed the focus of his work after Prof. Shinya Yamanaka of Kyoto University, who won the 2010 Kyoto Prize for advanced technology, made known his successes with iPS cells in 2007: «Once Yamanaka solved the problem, I turned around virtually my entire programme to take advantage of that breakthrough,» he sayIn the June 2010 issue of Nature Medicine, in an interview with theBoston - based researcher, Daley tells how he further changed the focus of his work after Prof. Shinya Yamanaka of Kyoto University, who won the 2010 Kyoto Prize for advanced technology, made known his successes with iPS cells in 2007: «Once Yamanaka solved the problem, I turned around virtually my entire programme to take advantage of that breakthrough,» he sayin an interview with theBoston - based researcher, Daley tells how he further changed the focus of his work after Prof. Shinya Yamanaka of Kyoto University, who won the 2010 Kyoto Prize for advanced technology, made known his successes with iPS cells in 2007: «Once Yamanaka solved the problem, I turned around virtually my entire programme to take advantage of that breakthrough,» he sayin 2007: «Once Yamanaka solved the problem, I turned around virtually my entire programme to take advantage of that breakthrough,» he says.

Also there is evidence of molecular mechanisms in the cell membranes that can amplify small changes in the field to produce large changes in neural activity.13 On the other hand, earlier tests of Kohler's theory found that interference with electrical gradients over the cortex had no effect on behavioral measures (see note 11 for reference to these studies).

Such was the comfortable vista which, less than a century ago, began abruptly to change beneath our gaze, something in the fashion of those organic tissues in the living body which, after long remaining harmless and dormant, their cells apparently indistinguishable from those of the surrounding tissue, suddenly burst into dangerous growth.

In a similar vein Mr. Percival Lowell writes: «When we have, as we say, an idea, what happens inside of us is probably something like this: the neural current of molecular change passes up the nerves, and through the ganglia reaches at last the cortical cells....

Under Child's theory there is complete continuity from the reaction of the cell with its environment, which constitutes the primary metabolic gradient, and from the later reactions, by which the pattern of the developing embryo is laid down in accordance with the changing gradient pattern, to the intellectual processes by which the adult organism adjusts its relations to the outside world.

The DNA blueprints for each cell is written in a common chemical language capable of adapting to changing environmental conditions.

Ecological perspective insists that we are in the most profound ways, «not our own» we belong from the cells of our bodies to the finest creation of our minds, to the intricate, constantly changing cosmos.

Extracts from this garlic even protected cells in a laboratory dish from certain types of damage.13 This isn't really surprising when you consider the nutritional changes that typically occur in plants when they sprout.

The change in length along the Primary Axis of the load cell between no - load and Rated Load conditions.

The change in load cell output occurring with time, while under load, and with all environmental conditions and other variables remaining constant; usually measured with Rated Load applied and expressed as a percent of Rated Output over a specific period of time.

Keep in mind that if your baby has been ill recently, his iron levels may be temporarily low due to the illness (see Hoffman, Ronald, et al. «Chapter 154: Hematologic Manifestations of Childhood Illness: Infectious Disease Changes in Red Blood Cells: Anemia of Acute Infections.»

The introduction of infant formula to babies» diets changes the infants» gut microbiome, thus affecting the response of the infant immune system to pathogens.47 - 51 A greater amount of natural - killer cells, suggesting a more mature immune system, have been found in breastfed infants than in formula - fed infants.52 In addition, pH level in the stomach of breastfed children is better for the promotion of the protein - lipid α - lactalbumin (termed HAMLET), which induces apoptosislike death in tumor cells.51, in breastfed infants than in formula - fed infants.52 In addition, pH level in the stomach of breastfed children is better for the promotion of the protein - lipid α - lactalbumin (termed HAMLET), which induces apoptosislike death in tumor cells.51, in formula - fed infants.52 In addition, pH level in the stomach of breastfed children is better for the promotion of the protein - lipid α - lactalbumin (termed HAMLET), which induces apoptosislike death in tumor cells.51, In addition, pH level in the stomach of breastfed children is better for the promotion of the protein - lipid α - lactalbumin (termed HAMLET), which induces apoptosislike death in tumor cells.51, in the stomach of breastfed children is better for the promotion of the protein - lipid α - lactalbumin (termed HAMLET), which induces apoptosislike death in tumor cells.51, in tumor cells.51, 53

Since meconium is made of amniotic fluid, mucus, skin cells, and other stuff ingested in utero, it doesn't really smell — so you may not realize it's time for a diaper change.

Exposure to dioxins during pregnancy harms the cells in rapidly - changing breast tissue, which may explain why some women have trouble breastfeeding or don't produce enough milk, according to a University of Rochester Medical Center study.

It occurs when some of the red blood cells change into a «sickle» shape and cause a buildup of red blood cells in small blood vessels.

Even in the Be Small, I can fit four size four diapers, a soft package of wipes, my wallet, my cell phone, a lipstick and make - up compact, keys, a package of toddler snacks, her SIGG sippy cup, a change of pants and shirt for baby, my pouch sling, and the coordinating changing pad.

The composition of your blood also changes, creating a higher ratio of plasma to red blood cells than in non-pregnant women.

Some of these changes happen in the final weeks of pregnancy, including the stage when red blood cell production is transferred from the liver to the bone marrow.

Secretion of the hormones estrogen and progesterone set the stage for dramatic changes that take place in the breast during pregnancy: a massive proliferation of mammary epithelial cells, and the formation of thousands of ductal structures, which support milk production and transport during lactation.

The department has announced new security protocols including increased cell searches and bed checks, staffing and supervision changes, and installation of new security technology in tunnels and heart beat detection monitors at vehicle screening locations.

However, in 2007 Professor Wilmut announced that he had decided to change to an alternative method of research pioneered in Japan, known as direct reprogramming or «de-differentiation», which could create human embryonic cells without using human eggs or cloning human embryos.

He added: «The important thing is that you work with people who are like - minded and interested in pursuing the same sort of things where you can, and we will, whether the subject is stem cell or whether the subject is climate change.»

The scientists recorded the molecular and genetic changes in the smoke - exposed cells over 10 to 15 months, which the scientists say may be similar to 20 to 30 years of smoking, and compared the changes to bronchial cells that had not been exposed to the liquid smoke.

Scientists must seek a new, more energetic engagement with Americans if they are to overcome public skepticism on issues ranging from climate change to stem cell research, AAAS CEO Alan I. Leshner writes in a commentary in The Chronicle of Higher Education.

She demonstrated that early experience leads to lasting changes in the molecular structure of the brain and discovered a gene involved in the spread of brain cancer cells into healthy brain tissue.

Scientists at the Johns Hopkins Kimmel Cancer Center say they have preliminary evidence in laboratory - grown, human airway cells that a condensed form of cigarette smoke triggers so - called «epigenetic» changes in the cells consistent with the earliest steps toward lung cancer development.

[Robert Siman et al, Serum SNTF Increases in Concussed Professional Ice Hockey Players and Relates to the Severity of Post Concussion Symptoms] A strong blow to the head causes chemical changes within nerve cells that damage their structural proteins.

«When a new substance forms during a chemical reaction, many students think that the atoms and molecules have actually changed into something new, whereas they simply rearranged, that the mass increase of plants is due to minerals in the soil, or that cell division alone accounts for animal growth,» said Cari Herrmann Abell, a senior research associate at Project 2061.

When compared to other religious groups, Evangelicals have often been more wary of science as evidenced in debates about evolution, stem cell research, and climate change.

Many of the mutations in ASD, Yan explained, result from chromatin remodeling factors, which are involved in dynamically changing the structure of chromatin, the complex of genetic material in the cell nucleus that condenses into chromosomes.

The acceleration of the healing process occurs due to changes in the microenvironment in the wound, which change the behaviour of specific immune cells.

That cold tolerance is linked to changes in a specific cold - sensing protein in the sensory nerve cells of the ground squirrels and another hibernator, the Syrian hamster, researchers report in the Dec. 19 Cell Reports.

Changes in the normal function of Ras proteins — mutations which are responsible for 30 percent of all cancers — can power cancer cells to grow and spread.

«In addition, changes in how the genes are expressed (turned on or off) could be used in the future to predict how and when the cancer cells will spread to other parts of the body and how fast they will grow.&raquIn addition, changes in how the genes are expressed (turned on or off) could be used in the future to predict how and when the cancer cells will spread to other parts of the body and how fast they will grow.&raquin how the genes are expressed (turned on or off) could be used in the future to predict how and when the cancer cells will spread to other parts of the body and how fast they will grow.&raquin the future to predict how and when the cancer cells will spread to other parts of the body and how fast they will grow.»

Nevertheless, Vallier is concerned about the number of changes in the reprogrammed cell lines.

One of the crucial adaptations involved changes in a gene that encodes a viral protein used to enter cells.