Sentences with phrase «changes in data availability»

To obtain consistent changes over time, the main analysis is actually of anomalies (departures from the climatological mean at each site) as these are more robust to changes in data availability.

Not exact matches

Actual results and the timing of events could differ materially from those anticipated in the forward - looking statements due to these risks and uncertainties as well as other factors, which include, without limitation: the uncertain timing of, and risks relating to, the executive search process; risks related to the potential failure of eptinezumab to demonstrate safety and efficacy in clinical testing; Alder's ability to conduct clinical trials and studies of eptinezumab sufficient to achieve a positive completion; the availability of data at the expected times; the clinical, therapeutic and commercial value of eptinezumab; risks and uncertainties related to regulatory application, review and approval processes and Alder's compliance with applicable legal and regulatory requirements; risks and uncertainties relating to the manufacture of eptinezumab; Alder's ability to obtain and protect intellectual property rights, and operate without infringing on the intellectual property rights of others; the uncertain timing and level of expenses associated with Alder's development and commercialization activities; the sufficiency of Alder's capital and other resources; market competition; changes in economic and business conditions; and other factors discussed under the caption «Risk Factors» in Alder's Annual Report on Form 10 - K for the fiscal year ended December 31, 2017, which was filed with the Securities and Exchange Commission (SEC) on February 26, 2018, and is available on the SEC's website at www.sec.gov.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

Examples of these risks, uncertainties and other factors include, but are not limited to the impact of: adverse general economic and related factors, such as fluctuating or increasing levels of unemployment, underemployment and the volatility of fuel prices, declines in the securities and real estate markets, and perceptions of these conditions that decrease the level of disposable income of consumers or consumer confidence; adverse events impacting the security of travel, such as terrorist acts, armed conflict and threats thereof, acts of piracy, and other international events; the risks and increased costs associated with operating internationally; our expansion into and investments in new markets; breaches in data security or other disturbances to our information technology and other networks; the spread of epidemics and viral outbreaks; adverse incidents involving cruise ships; changes in fuel prices and / or other cruise operating costs; any impairment of our tradenames or goodwill; our hedging strategies; our inability to obtain adequate insurance coverage; our substantial indebtedness, including the ability to raise additional capital to fund our operations, and to generate the necessary amount of cash to service our existing debt; restrictions in the agreements governing our indebtedness that limit our flexibility in operating our business; the significant portion of our assets pledged as collateral under our existing debt agreements and the ability of our creditors to accelerate the repayment of our indebtedness; volatility and disruptions in the global credit and financial markets, which may adversely affect our ability to borrow and could increase our counterparty credit risks, including those under our credit facilities, derivatives, contingent obligations, insurance contracts and new ship progress payment guarantees; fluctuations in foreign currency exchange rates; overcapacity in key markets or globally; our inability to recruit or retain qualified personnel or the loss of key personnel; future changes relating to how external distribution channels sell and market our cruises; our reliance on third parties to provide hotel management services to certain ships and certain other services; delays in our shipbuilding program and ship repairs, maintenance and refurbishments; future increases in the price of, or major changes or reduction in, commercial airline services; seasonal variations in passenger fare rates and occupancy levels at different times of the year; our ability to keep pace with developments in technology; amendments to our collective bargaining agreements for crew members and other employee relation issues; the continued availability of attractive port destinations; pending or threatened litigation, investigations and enforcement actions; changes involving the tax and environmental regulatory regimes in which we operate; and other factors set forth under «Risk Factors» in our most recently filed Annual Report on Form 10 - K and subsequent filings by the Company with the Securities and Exchange Commission.

The main findings in this analysis are summarized in Figure 7 and include the trend - line changes from 1995 to 2011 for the availability of sugars and sweeteners (FAOSTAT), the apparent consumption of refined sugars (ABS), and sugars added to carbonated soft drinks (industry data) compared with the changes in total sugars, added sugars, and sugars as soft drinks according to national dietary surveys in 1995 and 2011 — 2012.

In the current study, we provide novel data on changes in the availability of added and refined sugars and in recorded intakes of total sugars, added sugars, SSB, carbonated soft drinks, juices, confectionery, and alcohol consumption in Australian adults and children between the 2 most recent national dietary surveys in 1995 and 2011 — 201In the current study, we provide novel data on changes in the availability of added and refined sugars and in recorded intakes of total sugars, added sugars, SSB, carbonated soft drinks, juices, confectionery, and alcohol consumption in Australian adults and children between the 2 most recent national dietary surveys in 1995 and 2011 — 201in the availability of added and refined sugars and in recorded intakes of total sugars, added sugars, SSB, carbonated soft drinks, juices, confectionery, and alcohol consumption in Australian adults and children between the 2 most recent national dietary surveys in 1995 and 2011 — 201in recorded intakes of total sugars, added sugars, SSB, carbonated soft drinks, juices, confectionery, and alcohol consumption in Australian adults and children between the 2 most recent national dietary surveys in 1995 and 2011 — 201in Australian adults and children between the 2 most recent national dietary surveys in 1995 and 2011 — 201in 1995 and 2011 — 2012.

Objective: We investigated recent trends in the availability of sugars and sweeteners and changes in intakes of total sugars, added sugars, and SSBs in Australia by using multiple, independent data sources.

«Though the annual burdens report won't reflect the effects of recent changes for several years because of a lag in the availability of data, New York's 2011 state - local tax burden — the highest in the nation — shows just how necessary tax reform is in New York,» Tax Foundation analyst Liz Malm said.

By cross-referencing these impacts with data on local elephant populations, forest tree - species composition and structure, nutrient availability, and understory growth in existing Central African forests — both protected and unprotected ones alike — Poulsen and his team determined that up to 96 percent of all forests in the region were susceptible to dramatic changes if elephant populations shrank or disappeared.

«Our data indicate that it is primarily food availability, and not changes in winter temperatures and hunting pressure, that determines where the geese stay in winter,» says Kevin K. Clausen.

The paleoclimate data, which included mainly changes in the oxygen isotopes of the calcium carbonate deposits, were then compared to similar records from other caves, ice cores, and sediment records as well as model predictions for water availability in the Middle East and west central Asia today and into the future.

It is important to the de-extinction effort because it shows (as our data do) that passenger pigeon populations fluctuated in size through time, as resource availability changed.

The finding seems similar to «one small step for a man, one giant leap for mankind» — but instead, its «one small temperature change but one giant argument for openness and transparency» in data collection and selection methods, sites selected, algorithms and source code availability and so on.

Many of the graphs in this report illustrate historical changes and future trends in climate compared to some reference period, with the choice of this period determined by the purpose of the graph and the availability of data.

Limited availability of data and a variety of uncertainties relating to future changes in climate, social and economic conditions, and the responses that will be made to address those changes, frustrate precise cost and economic loss inventories.

Changes in instrumentation and data availability have caused time - varying biases in estimates of global - and regional - average sea - surface temperature.

New data points to ways nutritionists might lobby for changes in trade and food aid to improve the nutrient availability for billions of people, researchers Jessica Fanzo and Stephen Wood say.2 months ago

CAS = Commission for Atmospheric Sciences CMDP = Climate Metrics and Diagnostic Panel CMIP = Coupled Model Intercomparison Project DAOS = Working Group on Data Assimilation and Observing Systems GASS = Global Atmospheric System Studies panel GEWEX = Global Energy and Water Cycle Experiment GLASS = Global Land - Atmosphere System Studies panel GOV = Global Ocean Data Assimilation Experiment (GODAE) Ocean View JWGFVR = Joint Working Group on Forecast Verification Research MJO - TF = Madden - Julian Oscillation Task Force PDEF = Working Group on Predictability, Dynamics and Ensemble Forecasting PPP = Polar Prediction Project QPF = Quantitative precipitation forecast S2S = Subseasonal to Seasonal Prediction Project SPARC = Stratospheric Processes and their Role in Climate TC = Tropical cyclone WCRP = World Climate Research Programme WCRP Grand Science Challenges • Climate Extremes • Clouds, Circulation and Climate Sensitivity • Melting Ice and Global Consequences • Regional Sea - Ice Change and Coastal Impacts • Water Availability WCRP JSC = Joint Scientific Committee WGCM = Working Group on Coupled Modelling WGSIP = Working Group on Subseasonal to Interdecadal Prediction WWRP = World Weather Research Programme YOPP = Year of Polar Prediction

The ability to hindcast the detailed changes in atmospheric composition over the past decade, particularly the variability of tropospheric O3 and CO, is limited by the availability of measurements and their integration with models and emissions data.

Thanks to the availability of data from satellite altimetry, Argo floats, and moored buoys in the tropical Pacific, this decadal phase change is the best - observed decadal climate shift in history.

This shabby analysis has been debunked by Richard Telford http://quantpalaeo.wordpress.com/2014/12/26/not-phraud-but-phoolishness/ His conclusion: «The changing geographic and seasonal patterns in data availability means that simply calculating the mean pH for each year will give all sorts of spurious trends in the analysis.

(a) Scientific, socio - economic, technical, and methodological issues, including the role of forests, in particular tropical forests, in the global carbon cycle; definitional issues, including those relating to links between deforestation and degradation; data availability and quality; scale; rates and drivers of deforestation; estimation of changes in carbon stocks and forest cover; and related uncertainties;

The introduction of Jio has fundamentally changed the way Indians consume cellular data, and wide availability of 4G data saw a dramatic boost in sales of budget phones.

Toyota Engineering and Manufacturing North America (Princeton, IN) 10/2001 — 5/2010 Technician / Skilled Maintenance Team Leader • Provided support and technical expertise on Allen Bradley PLC - 5 and Control Logic, as well as designed new screens for HMI using RSView and mapped all data and alarms needed for monitoring production equipment • Programmed PLC's using Rockwell software as required by production, utilizing PLC as a troubleshooting tool to locate and repair process problems • Repaired and maintained all three phase medium and low voltage motors, programming medium voltage control relays to meet manufacturer specifications and monitor applicable data from motors as well as engineering data and motor manufacturing parameters into VFD's • Established PM schedules for maintaining floor conveyors, robots, RFID, air handling, sludge, paint mix room, and lifters, assisting T / M's with performing preventative maintenance on equipment • Ensured calibration of environmental equipment to maintain state and federal guidelines, performing the calibration procedures and repair of micrometers, calipers, and profilometers as required by ISO standards • Identified and developed countermeasures to manufacturing - related problems with equipment, monitoring corrective actions and resolution implementation to ensure problems were below 2 % of operational availability • Review associated work instructions for changes as needed to maintain quality, safety, and environmental standards, while planning and coordinating weekly safety meetings and training for team members

In reporting against each of the headline indicators and strategic change indicators in the first report, the Steering Committee has noted limitations in data availability and qualitIn reporting against each of the headline indicators and strategic change indicators in the first report, the Steering Committee has noted limitations in data availability and qualitin the first report, the Steering Committee has noted limitations in data availability and qualitin data availability and quality.

The availability of this second wave of data allows researchers to look at change over a 5 - year period in relationships or to examine the effect of relationship characteristics at W1 on some later outcome.

This report from 2009 examines the availability of housing data on a country - by - country basis and assembles roughly comparable data over a significant time period to identify changing price levels in the international housing markets.