Scientists at the Johns Hopkins Kimmel Cancer Center say they have preliminary evidence in laboratory - grown, human airway cells that a condensed form of cigarette smoke triggers so - called «epigenetic»
changes in the cells consistent with the earliest steps toward lung cancer development.
Not exact matches
The function of these genes were involved
in molecular maintenance strategies, such as DNA repair, chromosomal maintenance, immune response and programmed
cell death The authors argue that the «slower rate of
change in these functions is
consistent with increased constraint on somatic
cell maintenance as would be required
in these relatively long - lived and large - bodied mammals, illustrated by the additional large and long - lived species with slower rates
in these genes (e.g. double - strand break repair gene XRCC4 is also highly constrained
in elephant.»
Although similar numbers of total splenic gp33 - LCMV — specific T
cells were observed between genotypes (Fig. 5B), the distribution of gp33 - LCMV — specific CD8 + T
cell effector and memory subsets were altered, such that there was a significantly lower percentage of short - term effector T
cells and reciprocal
changes in memory precursor
cells among gp33 - specifc CD8 + T
cells in WT relative to DKO mice (Fig. 5C), with a trend
in changes in absolute
cell numbers,
consistent with temporal data from peripheral blood (Fig. 5A).
While the small
changes in lineage transcription observed
in our data set would be
consistent with a stochastic model, the ES
cell model described
in Figure 9 would require both cross-repression and additional positive feedback loops to drive these random
changes in gene expression down multiple distinct routes.
In «# 687» particularly, among the works on view, an observer has to strain to see, or believe — because it is true — that the red delineating the tiny
cells and occupying their centers remains
consistent as the array showers down over the
changing ground colors.