Sentences with phrase «changes in the expression of»

They firmly believed that, though some changes in the expression of Christian doctrine were needed, the essential truth of Christianity would stand firm and would be expressed again in new and more appropriate forms.

Utilizing this very sensitive technique they were able to demonstrate significant changes in the expression of over 4000 genes.

Prolonged oral administration of a pan-retinoic acid receptor antagonist inhibits spermatogenesis in mice with a rapid recovery and changes in the expression of influx and efflux transporters.

Other rodent models that utilize changes in expression of α - synuclein have also reported lower anxiety levels.

Hockemeyer says that it's unlikely to be another mutation, but rather an epigenetic change that affects expression of the telomerase gene, or a change in the expression of a transcription factor or other regulatory proteins that binds to the promoter upstream of the telomerase gene.

«We also found that reduced cohesin led to changes in the expression of genes involved in nerve cell development and the response to an immune signaling protein,» corresponding author Toshihide Yamashita says.

The study shows that even small, tissue - specific changes in the expression of genes can have noticeable morphological effects.

Its appearance following starvation and other stresses is associated with changes in the expression of over 500 genes, most prominently genes for the structural RNAs that are components of the ribosome — the enzyme responsible for protein synthesis.

The brain attempts to adapt and respond to those challenges and that occurs in large part through changes in expression of brain genes through epigenetic mechanisms.

But the researchers found no significant changes in the expression of genes known to be involved in calcification from prior studies comparing strains with dramatically different calcification levels.

Sanny S. W. Chung, Xiangyuan Wang, Debra J. Wolgemuth; Prolonged Oral Administration of a Pan-Retinoic Acid Receptor Antagonist Inhibits Spermatogenesis in Mice With a Rapid Recovery and Changes in the Expression of Influx and Efflux Transporters, Endocrinology, Volume 157, Issue 4, 1 April 2016, Pages 1601 — 1612, https://doi.org/10.1210/en.2015-1675

CCG uses high - throughput techniques to identify and study mutations, large rearrangements of the genome, increases and decreases in DNA copy number, chemical modifications to DNA, and changes in the expression of RNA and proteins.

Because they influence the activity of many «downstream» genetic targets, small changes in the expression of these regulatory genes can have an enormous impact.

This effect is not associated with compensatory changes in the expression of any other amino acid transporter.

Antagonists of growth hormone releasing hormone (GHRH) given before whole body radiation lead to modulation of radiation response and organ - specific changes in the expression of angiogenesis.

Our data suggest that changes in the expression of genes associated with drug resistance and cancer cell «stemness», induced by treatment with MIA - 602, lead to a significant reduction in the efflux capacity of drug resistant cells.

Analysis of transcriptomes in tumour tissues from wild - type mice and Slc6a14 - null mice indicated no compensatory changes in the expression of any other amino acid transporter mRNA.

In colon and lung of the knockout mice, there were no major compensatory changes in the expression of any of the 12 amino acid transporter mRNAs examined (Figure 1C).

The plasma amino acids were similar in wild - type and knockout mice and there were no major compensatory changes in the expression of other amino acid transporter mRNAs.

Furthermore, no changes in expression of genes involved in proliferation or apoptosis were seen in the total population in any lines supporting our in vitro findings.

The researchers also showed that regular feeding with the Lactobacillus strain caused changes in the expression of receptors for the neurotransmitter GABA in the mouse brain, which is the first time that it has been demonstrated that potential probiotics have a direct effect on brain chemistry in normal situations.

Robust changes in expression of brain - derived neurotrophic factor (BDNF) mRNA and protein across the brain do not translate to detectable changes in BDNF levels in CSF or plasma.

Moreover, for the first time, they show that changes in whole - organism phenotypic responses are accompanied by changes in the expression of genes related to intracellular regulatory processes rather than genes thought to be essential for calcification.

Not exact matches

«Our stance in support of the liberties of peaceful, personal expression afforded to all Americans will remains strong and we will continue to encourage our players to respectfully use their earned platform to inspire positive change in our nation and throughout society.»

The 30 - day Fed Fund futures can be used as a guide to predict when the Fed might increase interest rates since the prices are an expression of trader's views on the likelihood of changes in U.S. monetary policy.

Sophie not only asked questions of job candidates, but it also studied their faces for changes in expressions that could indicate whether they may be fibbing.

All expressions of opinion are subject to change without notice in reaction to shifting market, economic and geo - political conditions.

All expressions of opinion are subject to change without notice in reaction to shifting market conditions.

Harrison then appears as a formidable change agent, a transformational leader in the truest meaning of that tired expression.

In our leadership work we show our leaders how to transmit a precise type of leadership impact to meet different business outcomes by using various specific postures and facial expressions that prime your behaviors to achieve the particular business outcome, as well as signal to others how your behaviors will change outcomes.

It is the normal expression of change, everywhere in the world - whether it is always progress, or improvement, is of course another question.

And thank you America for the freedom of speech you granted the world and has provided us the utilities of communications asking us to contribute with our expressions towards» Change for the Good of ship and passengers on board» since there is no Ark better than earth to save us in this wide unpredictable space?!

For those who think in this way, changing the structures of thought and perception built into so much of our science would be too indirect a contribution to the relief of suffering to be a true expression of Buddhist compassion.

So the Supreme Court, when it practices judicial activism, undercuts democratic participation not only by substituting its own assertoric judgment for democratic deliberation, or by ignoring the plain letter of the constitution in favor of its own political inclinations, but also by understanding itself as a council of philosopher kings (versus really good lawyers) prudentially adjusting the fundamental nature of American democracy to fit the ever changing historical horizon that provides the context for its expression.

As an active or a forward - moving process it must necessarily negate its particular expressions, and progressively transform itself as it becomes incarnate in a continually changing series of historical moments.

And Grossman, without changing expression, says, «I don't see a lot of money in this.»

If we succeed in changing the hierarchies we have imposed on people according to their race and color and sex, then we can have a world of persons, of horizontal relationship rather than hierarchy, a world of expression rather than oppression, where «there are no more distinctions between Jew and Greek, slave and free, male and female,» where we are all «one in Christ Jesus.»

But again, and even with the possible implication of divine judgment in the death of Rachel, we see the repeated motif of the Jacob cycle: the tension between sin and divine grace, the expression of faith that Jacob - Israel is saved and redeemed only by the will and purpose of God (35:5), and finally the repetition of the promise and the blessing, and the second account of the changing of Jacob's name to Israel.

In broad outline, Hartshorne's dependence upon White - head finds clearest expression in his enthusiastic adoption of Whitehead's view of the universe as essentially one of perpetual change and becominIn broad outline, Hartshorne's dependence upon White - head finds clearest expression in his enthusiastic adoption of Whitehead's view of the universe as essentially one of perpetual change and becominin his enthusiastic adoption of Whitehead's view of the universe as essentially one of perpetual change and becoming.

The conference was spearheaded by Michael Davidson, a man of God who came out of the homosexual life many years ago and heads up a group called Core Issues Trust («a non-profit Christian ministry supporting men and women with homosexual issues who voluntarily seek change in sexual preference and expression») and by Andrea Williams, dynamic barrister and CEO of Christian Concern (an organization that seeks to be «a strong Christian voice in the public sphere») and the Christian Legal Centre (a legal defense team for British Christians persecuted for their faith).

There is a change in our culture that challenges our theories, let alone the practice, of access and free expression.

The pastoral role is concerned with ministry to individuals; the priestly role has to do with the proclamation of the faith and with leadership in the liturgical life of the church; the prophetic role focuses on judging the level of humaneness in the social order and pointing to the changes required if common justice is to be approximated; the kingly role takes up governance and the expression of neighbor love through responsible corporate action.

Then there is wisdom, human wisdom, man's intelligent ordering of his life, the serious employment of right reason, the attempt to find the proper way of life, the whole enterprise that takes form in political action and personal morality, in social work and poetry, in economic management and the building of temples, in the constant improvement of justice by changing laws, in philosophy and technology, the manifold wisdom of man which is also inscribed in the wisdom of God and which may be an expression of this wisdom, the first of all God's works that rejoiced before him when he laid the foundations of the world (Proverbs 8:22 ff.).

When in 169 one of the contestants, Menelaus, was returned to the office, Antiochus, who had already incurred the bitter resentment of faithful Jews by his interference, sought to correct his financial plight by entering the Temple himself and stripping it of its considerable movable wealth.31 Antiochus became at once the object of Judaism's bitterest hate; and no doubt in part in retaliation but also as an expression of this ardent Hellenist's frustration with a people slow to change, he effected an otherwise quite unprovoked attack on Jerusalem in 168.

When we have done this, we shall be in a better position to understand how the idiom may continue to be used as an expression of our hope in the face of a fast - changing world where so much is uncertain.

The criteriology of the divine, Nabert says, «is the expression of the greatest effort that consciousness can make in order to take away the conditions which prevent it from attaining complete satisfaction, when it attempts in the very core of its finitude to justify itself, to change itself into a radical purity of its intention.

While process theism welcomes expressions of God's dynamic activity, I for one am hesitant ever to endorse any change in God's values not dictated by a change in the objective situation.

Abusing their trust, global governance agents of change use the fuzzy expression «gender equality» in the developing world allowing it to be understood as a policy enhancing a greater recognition of the inherent equal dignity of the woman, while in fact it hides their own agenda.

Readers will have to forgive the technical expressions - some of which may be familiar to Ivy League graduates, though I am still not sure about «supersessionisal» They will also note that there are nearly 150 pages of notes - in case you think that the author is short - changing you!

But, in the courts and other public forums, the ACLU now has impressive competition, while the political sea change of November 1994 has created a circumstance much more sympathetic to the public expression of arguments informed by religious tradition.