Not exact matches
As sensitive as alternative splicing reacts to (
slightly) elevated temperature, a temperature - induced
change in
gene expression by fever appears to be a logical consequence.
Compared with living people, Neandertals and ancient Siberians known as Denisovans had
slightly different patterns of DNA methylation — a chemical modification of DNA that doesn't
change the information in
genes but helps control
gene activity.
With this type of cancer, the
genes in the white blood cells affected
change slightly, causing two chromosomes to cross.
While the cell is in the process of copying its genetic material, the new DNA would then replace a nearly identical existing
gene segment in the cell,
changing it
slightly.
By
slightly changing these master
genes, evolution could have an outsized effect on overall expression without as much chance of negative mutations, Gilad says.
Given that most amino acid
changes are
slightly deleterious [12] and assuming that most
genes in the genome are relatively conserved, one would expect that regions of the genome with a low recombination rate, when compared to those with a high rate, would show i) a higher ratio of non-synonymous (amino acid replacing) to synonymous (silent) substitutions (ω) and ii) a higher degree of protein divergence (dA) due, in both cases, to the reduced effectiveness of selection against
slightly deleterious mutations.